Zobrazeno 1 - 10
of 746
pro vyhledávání: '"S. McCullough"'
Autor:
Jon W. S. McCullough, Peter V. Coveney
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract Uncertainty quantification is becoming a key tool to ensure that numerical models can be sufficiently trusted to be used in domains such as medical device design. Demonstration of how input parameters impact the quantities of interest genera
Externí odkaz:
https://doaj.org/article/08de63607c9c4777b859e348b18ab7e8
Autor:
Jon W. S. McCullough, Peter V. Coveney
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract On a global scale, cerebro- and cardiovascular diseases have long been one of the leading causes of death and disability and their prevalence appears to be increasing in recent times. Understanding potential biomarkers and risk factors will
Externí odkaz:
https://doaj.org/article/98554da4b976414d883caf08ca0011cb
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 14, p 7975 (2024)
Phosphohistidine (pHis) is a reversible protein post-translational modification (PTM) that is currently poorly understood. The P-N bond in pHis is heat and acid-sensitive, making it more challenging to study than the canonical phosphoamino acids pSer
Externí odkaz:
https://doaj.org/article/f83249d9f5de442fa66e6b5108ce86e6
Autor:
C. I. Ma, J. A. Tirtorahardjo, S. S. Schweizer, J. Zhang, Z. Fang, L. Xing, M. Xu, D. A. Herman, M. T. Kleinman, B. S. McCullough, A. M. Barrios, R. M. Andrade
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 2 (2024)
ABSTRACTAuranofin, an FDA-approved drug for rheumatoid arthritis, has emerged as a promising antiparasitic medication in recent years. The gold(I) ion in auranofin is postulated to be responsible for its antiparasitic activity. Notably, aurothiomalat
Externí odkaz:
https://doaj.org/article/c2d4775e6d894b9ca43992fd76913522
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Substantial effort is being invested in the creation of a virtual human—a model which will improve our understanding of human physiology and diseases and assist clinicians in the design of personalised medical treatments. A central challen
Externí odkaz:
https://doaj.org/article/ab3dd9bec2374d8caffad1c837ac3f21
Autor:
Jason B. Gibbons, Edward C. Norton, Jeffrey S. McCullough, David O. Meltzer, Jill Lavigne, Virginia C. Fiedler, Robert D. Gibbons
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Vitamin D deficiency has long been associated with reduced immune function that can lead to viral infection. Several studies have shown that Vitamin D deficiency is associated with increases the risk of infection with COVID-19. However, it i
Externí odkaz:
https://doaj.org/article/2aeb4d78921a490c9c4c3911f998bc06
Autor:
Mitchell R. McGill, Laura P. James, Sandra S. McCullough, Jeffery H. Moran, Samuel E. Mathews, Eric C. Peterson, Davis P. Fleming, Morgan E. Tripod, Joel H. Vazquez, Stefanie Kennon‐McGill, Horace J. Spencer, Jonathan A. Dranoff
Publikováno v:
Hepatology Communications, Vol 6, Iss 2, Pp 361-373 (2022)
Current guidelines recommend restricting acetaminophen (APAP) use in patients with cirrhosis, but evidence to support that recommendation is lacking. Prior studies focused on pharmacokinetics (PK) of APAP in cirrhosis but did not rigorously examine c
Externí odkaz:
https://doaj.org/article/2ada1934f2dc4560b741f3c946e06c70
Autor:
J. W. S. McCullough, P. V. Coveney
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Many numerical studies of blood flow impose a rigid wall assumption due to the simplicity of its implementation compared to a full coupling with a solid mechanics model. In this paper, we present a localised method for incorporating the effe
Externí odkaz:
https://doaj.org/article/dd3c12d8d95d4e9099b49bbec65f204a
Autor:
Melissa M. Clemens, Stefanie Kennon-McGill, Joel H. Vazquez, Owen W. Stephens, Erich A. Peterson, Donald J. Johann, Felicia D. Allard, Eric U. Yee, Sandra S. McCullough, Laura P. James, Brian N. Finck, Mitchell R. McGill
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3836-3846 (2021)
We previously demonstrated that endogenous phosphatidic acid (PA) promotes liver regeneration after acetaminophen (APAP) hepatotoxicity. Here, we hypothesized that exogenous PA is also beneficial. To test that, we treated mice with a toxic APAP dose
Externí odkaz:
https://doaj.org/article/4a3814ab452048b8af9da9c8afc86904
Autor:
Michael Pienta, MD, MS, Supriya Shore, MBBS, MSc, MSc, Francis D. Pagani, MD, PhD, Donald S. Likosky, PhD, Ashraf Shaaban, Abdel Aziz Abou El Ela, MB, BCH, Paul C. Tang, MD, PhD, Michael P. Thompson, PhD, Keith Aaronson, MD, MS, Supriya Shore, MBBS, Thomas Cascino, MD, MSc, Katherine B. Salciccioli, MD, Min Zhang, PhD, Jeffrey S. McCullough, PhD, Michelle Hou, MS, Allison M. Janda, MD, Michael R. Mathis, MD, Tessa M.F. Watt, MD, MSc, Michael J. Pienta, MD, MS, Alexander Brescia, MD, MSc, Austin Airhart, Daniel Liesman, Khalil Nassar
Publikováno v:
JTCVS Open, Vol 8, Iss , Pp 405-411 (2021)
Externí odkaz:
https://doaj.org/article/b5a0c6a059134c7abbf1cb0166eee3e1