Zobrazeno 1 - 10
of 117
pro vyhledávání: '"S. Maughan"'
Autor:
Enric Domingo, Sanjay Rathee, Andrew Blake, Leslie Samuel, Graeme Murray, David Sebag-Montefiore, Simon Gollins, Nicholas West, Rubina Begum, Susan Richman, Phil Quirke, Keara Redmond, Aikaterini Chatzipli, Alessandro Barberis, Sylvana Hassanieh, Umair Mahmood, Michael Youdell, Ultan McDermott, Viktor Koelzer, Simon Leedham, Ian Tomlinson, Philip Dunne, Francesca M. Buffa, Timothy S. Maughan, Francesca Buffa, Geoffrey Higgins, Christopher Holmes, Timothy Maughan, Gillies McKenna, James Robineau, Philip Quirke, Matthew Seymour, Richard Kennedy, Mark Lawler, Manuel Salto-Tellez, Peter Campbell, Claire Hardy, Simon Bach, Andrew Beggs, Jean-Baptiste Cazier, Gary Middleton, Dion Morton, Celina Whalley, Louise Brown, Richard Kaplan, Richard Wilson, Richard Adams, Richard Sullivan, Paul Harkin, Steven Walker, Jim Hill, Chieh-Hsi Wu, Dennis Horgan
Publikováno v:
EBioMedicine, Vol 106, Iss , Pp 105228- (2024)
Summary: Background: It is uncertain which biological features underpin the response of rectal cancer (RC) to radiotherapy. No biomarker is currently in clinical use to select patients for treatment modifications. Methods: We identified two cohorts o
Externí odkaz:
https://doaj.org/article/6732596b11c54a618ebd9beb8dd8725c
Autor:
Benjamin H. L. Harris, Matteo Di Giovannantonio, Ping Zhang, David A. Harris, Simon R. Lord, Naomi E. Allen, Tim S. Maughan, Richard J. Bryant, Adrian L. Harris, Gareth L. Bond, Francesca M. Buffa
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Cancer risk is associated with the widely debated measure body mass index (BMI). Fat mass and fat-free mass measurements from bioelectrical impedance may further clarify this association. The UK Biobank is a rare resource in which bioelectri
Externí odkaz:
https://doaj.org/article/2f3050f839a7488a9330c4b7083a5352
Autor:
Dustin J. Flanagan, Raheleh Amirkhah, David F. Vincent, Nuray Gundaz, Pauline Gentaz, Patrizia Cammareri, Aoife J. McCooey, Amy M. B. McCorry, Natalie C. Fisher, Hayley L. Davis, Rachel A. Ridgway, Jeroen Lohuis, Joshua D. G. Leach, Rene Jackstadt, Kathryn Gilroy, Elisa Mariella, Colin Nixon, William Clark, Ann Hedley, Elke K. Markert, Douglas Strathdee, Laurent Bartholin, Keara L. Redmond, Emma M. Kerr, Daniel B. Longley, Fiona Ginty, Sanghee Cho, Helen G. Coleman, Maurice B. Loughrey, Alberto Bardelli, Timothy S. Maughan, Andrew D. Campbell, Mark Lawler, Simon J. Leedham, Simon T. Barry, Gareth J. Inman, Jacco van Rheenen, Philip D. Dunne, Owen J. Sansom
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
It remains critical to identify colorectal cancers (CRC) that will disseminate as early as possible. Here, the authors identify CRC tumours that are aggressive and prone to early dissemination, characterised by epithelial TGFβ and growth-factor sign
Externí odkaz:
https://doaj.org/article/685f337608c24440b7e084866104173a
Autor:
Liam F. Spurr, Carlos A. Martinez, Rohan R. Katipally, Soumya C. Iyer, Sian A. Pugh, John A. Bridgewater, John N. Primrose, Enric Domingo, Timothy S. Maughan, Michael I. D’Angelica, Mark Talamonti, Mitchell C. Posner, Philip P. Connell, Ralph R. Weichselbaum, Sean P. Pitroda
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-7 (2022)
Abstract Personalized treatment approaches for patients with limited liver metastases from colorectal cancer are critically needed. By leveraging three large, independent cohorts of patients with colorectal liver metastases (n = 336), we found that a
Externí odkaz:
https://doaj.org/article/e959372b8763414ba78ff05df5b5708b
Autor:
Louise C Brown, David Fisher, Richard Adams, Jenny Seligmann, Matthew Seymour, Richard Kaplan, Susan D Richman, Philip Quirke, Rachel Butler, Helen Roberts, Janet Graham, Richard H Wilson, Timothy S Maughan
Publikováno v:
Efficacy and Mechanism Evaluation, Vol 9, Iss 9 (2022)
Background: Complex trials with innovative designs are becoming increasingly common and offer the potential to improve patient outcomes in a shorter time frame. There is evidence that patients with colorectal cancer fall into different subgroups with
Externí odkaz:
https://doaj.org/article/a710ce8c7ebb4534b2145ccccfea160e
Publikováno v:
Cancer Medicine, Vol 10, Iss 17, Pp 5983-5997 (2021)
Abstract Background Inflammation is a hallmark of cancer, and systemic markers of inflammation are increasingly recognised as negative prognostic factors for clinical outcome. Neutrophil‐to‐lymphocyte ratio (NLR) is readily available from routine
Externí odkaz:
https://doaj.org/article/0b367797c17b49b89739a561ef392fa2
Autor:
Amélie Viratham Pulsawatdi, Stephanie G. Craig, Victoria Bingham, Kris McCombe, Matthew P. Humphries, Seedevi Senevirathne, Susan D. Richman, Phil Quirke, Leticia Campo, Enric Domingo, Timothy S. Maughan, Jacqueline A. James, Manuel Salto‐Tellez
Publikováno v:
Molecular Oncology, Vol 14, Iss 10, Pp 2384-2402 (2020)
Multiplex immunofluorescence is a powerful tool for the simultaneous detection of tissue‐based biomarkers, revolutionising traditional immunohistochemistry. The Opal methodology allows up to eight biomarkers to be measured concomitantly without cro
Externí odkaz:
https://doaj.org/article/ddaedcd62c55444cbbab846a80836163
Autor:
John Fielden, Katherine Wiseman, Ignacio Torrecilla, Shudong Li, Samuel Hume, Shih-Chieh Chiang, Annamaria Ruggiano, Abhay Narayan Singh, Raimundo Freire, Sylvana Hassanieh, Enric Domingo, Iolanda Vendrell, Roman Fischer, Benedikt M. Kessler, Timothy S. Maughan, Sherif F. El-Khamisy, Kristijan Ramadan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Eukaryotic topoisomerase 1 (TOP1) regulates DNA topology to ensure efficient DNA replication and transcription. Here, the authors reveal insights into the molecular resolution of topoisomerase 1-DNA adducts by TEX264, p97 and SPRTN.
Externí odkaz:
https://doaj.org/article/8eb6f2f6a3d047b7b8052b86b27f7725
Autor:
Dustin J. Flanagan, Raheleh Amirkhah, David F. Vincent, Nuray Gunduz, Pauline Gentaz, Patrizia Cammareri, Aoife J. McCooey, Amy M. B. McCorry, Natalie C. Fisher, Hayley L. Davis, Rachel A. Ridgway, Jeroen Lohuis, Joshua D. G. Leach, Rene Jackstadt, Kathryn Gilroy, Elisa Mariella, Colin Nixon, William Clark, Ann Hedley, Elke K. Markert, Douglas Strathdee, Laurent Bartholin, Keara L. Redmond, Emma M. Kerr, Daniel B. Longley, Fiona Ginty, Sanghee Cho, Helen G. Coleman, Maurice B. Loughrey, Alberto Bardelli, Timothy S. Maughan, Andrew D. Campbell, Mark Lawler, Simon J. Leedham, Simon T. Barry, Gareth J. Inman, Jacco van Rheenen, Philip D. Dunne, Owen J. Sansom
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/d890b609d092453794d4b110a230e27b
Autor:
Liz Morrell, Joshua Hordern, Louise Brown, Matthew R. Sydes, Claire L. Amos, Richard S. Kaplan, Mahesh K. B. Parmar, Timothy S. Maughan
Publikováno v:
Trials, Vol 20, Iss 1, Pp 1-6 (2019)
Abstract Background Trials have become bigger and more complicated due to the complexity introduced by biomarker stratification, and the advent of multi-arm multi-stage trials, and umbrella and basket platform designs. The trials unit at University C
Externí odkaz:
https://doaj.org/article/70d633848f154ef581269da3c4f91311