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Molecular determinants of positive allosteric modulation of the human metabotropic glutamate receptor 2

Autor: A, Farinha, H, Lavreysen, L, Peeters, B, Russo, S, Masure, A A, Trabanco, J, Cid, G, Tresadern

Publikováno v: British journal of pharmacology. 172(9)

The activation of the metabotropic glutamate receptor 2 (mGlu2 ) reduces glutamatergic transmission in brain regions where excess excitatory signalling is implicated in disorders such as anxiety and schizophrenia. Positive allosteric modulators (PAMs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a2db646f928067d24e9e14a49e886f10
https://pubmed.ncbi.nlm.nih.gov/25571949

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Glycosylation of Natural Human Neutrophil Gelatinase B and Neutrophil Gelatinase B-Associated Lipocalin

Autor: T Bratt, N Borregaard, S Masure, Taj S. Mattu, David Harvey, Pauline M. Rudd, Raymond A. Dwek, Ghislain Opdenakker, P. E. Van den Steen, J Van Damme, Bernhard Kuster, Mark R. Wormald

Publikováno v: Rudd, P, Mattu, T, Masure, S, Bratt, T, Van Den Steen, P, Wormald, M, Küster, B, Harvey, D, Borregaard, N, Van Damme, J, Dwek, R & Opdenakker, G 1999, ' Glycosylation of natural human neutrophil Gelatinase B and neutrophil gelatinase B-associated lipocalin ', Biochemistry, vol. 38, pp. 13937-13950 .

Gelatinase B is a matrix metalloproteinase (MMP-9) involved in tissue remodeling, development, cancer, and inflammation. Neutrophils produce three major forms of (pro)gelatinase B: 92 kDa monomers, homodimers, and complexes of gelatinase B covalently

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dd0d1889aadba30573bcec49bd6be64
https://doi.org/10.1021/bi991162e

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Mouse Macrophage Derived Monocyte Chemotactic Protein-3: cDNA Cloning and Identification as MARC/FIC

Autor: G. Nys, P. Fiten, S. Masure, S. Thirion, Ghislain Opdenakker, J. Vandamme

Publikováno v: Biochemical and Biophysical Research Communications. 201:493-499

When the mouse macrophage cell line WEHI-3 is triggered with LPS it produces proteases and secondary cytokines including interleukin-6 and chemokines. In an attempt to isolate the mouse homologue of the human monocyte chemotactic protein-3 (MCP-3), a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d09c2c2a8902f71c3521bc8f6b6dddb3
https://doi.org/10.1006/bbrc.1994.1729

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Binding of GDNF and neurturin to human GDNF family receptor alpha 1 and 2. Influence of cRET and cooperative interactions

Autor: M, Cik, S, Masure, A S, Lesage, I, Van Der Linden, P, Van Gompel, M N, Pangalos, R D, Gordon, J E, Leysen

Publikováno v: The Journal of biological chemistry. 275(36)

The members of the glial cell line-derived neurotrophic factor (GDNF) family signal via binding to the glycosyl phosphatidylinositol-anchored membrane proteins, the GDNF family receptors alpha (GFRalpha), and activation of cRET. We performed a detail

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ff446e261cc8c272e821486992a8fee6
https://pubmed.ncbi.nlm.nih.gov/10829012

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Gelatinase B (MMP-9), but not its inhibitor (TIMP-1), dictates the growth rate of experimental thymic lymphoma

Autor: F, Aoudjit, S, Masure, G, Opdenakker, E F, Potworowski, Y, St-Pierre

Publikováno v: International journal of cancer. 82(5)

Dysregulation of metalloproteinase production at tumor sites contributes to the modification of local stromal tissue necessary for tumor development. Gelatinase B (matrix metalloproteinase-9, MMP-9) is one of the key enzymes that have been associated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::144d500dd9ac4a65465a14b95f3e4ade
https://pubmed.ncbi.nlm.nih.gov/10417774

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Cytokine-mediated regulation of human leukocyte gelatinases and role in arthritis

Autor: G, Opdenakker, S, Masure, B, Grillet, J, Van Damme

Publikováno v: Lymphokine and cytokine research. 10(4)

Gelatinases (type IV collagenases) produced by normal peripheral blood leukocytes were studied by the use of a substrate conversion assay. When monocytes were stimulated with IL-1 beta discrete amounts of a 85-kDa gelatinase were detected. This type

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6c764375e560cd189d1112b2296ad4c9
https://pubmed.ncbi.nlm.nih.gov/1932376

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