Zobrazeno 1 - 4
of 4
pro vyhledávání: '"S. Mariana Margarit"'
Autor:
E. Michael August, Lana Louise Smith Keenan, Jun Li, S. Mariana Margarit, Alexander Heim-Riether, Hans-Dieter Junker, Kathleen Haverty, Neil A. Farrow, Brandon Collins, Bennett T. Farmer, Thomas Neumann, Shuang Liang, John R. Proudfoot, Renate Sekul, Qiang Zhang, Donghong Amy Gao, Steven John Taylor, Zhaoming Xiong, Neil Moss, Melissa Hill-Drzewi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5321-5324
Discovery and optimization of potency and selectivity of a non-Zn-chelating MMP-13 inhibitor with the aid of protein co-crystal structural information is reported. This inhibitor was observed to have a binding mode distinct from previously published
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a91cc7f3c887b95e837900c788a1ecfd
https://doi.org/10.1016/j.bmcl.2009.07.151
https://doi.org/10.1016/j.bmcl.2009.07.151
Publikováno v:
Structure. 14:1219-1229
SummarySalmonella spp. require the ADP-ribosyltransferase activity of the SpvB protein for intracellular growth and systemic virulence. SpvB covalently modifies actin, causing cytoskeletal disruption and apoptosis. We report here the crystal structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::966f7582f75411c94d252af88cfbea60
https://doi.org/10.1016/j.str.2006.05.022
https://doi.org/10.1016/j.str.2006.05.022
Autor:
Dafna Bar-Sagi, Brian E. Hall, S. Mariana Margarit, Michelle Pirruccello, Holger Sondermann, John Kuriyan, Bhushan Nagar, André Hoelz
Publikováno v:
Cell. 112(5):685-695
Growth factor receptors activate Ras by recruiting the nucleotide exchange factor son of sevenless (SOS) to the cell membrane, thereby triggering the production of GTP-loaded Ras. Crystallographic analyses of Ras bound to the catalytic module of SOS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::345e8ce841db14c9899126ba23a22be8
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