Výsledky vyhledávání - "S. M. Swaney"

Novel 1,5-Diphenylpyrazole Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors with Enhanced Activity versus the Delavirdine-Resistant P236L Mutant: Lead Identification and SAR of 3- and 4-Substituted Derivatives

Autor: S M Swaney, Michael J. Genin, S M Poppe, Donna L. Romero, Carolyn Biles, Keiser Bj, Y. Yagi, W G Tarpley

Publikováno v: Journal of Medicinal Chemistry. 43:1034-1040

Through computationally directed broad screening, a novel 1, 5-diphenylpyrazole (DPP) class of HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs) has been discovered. Compound 2 (PNU-32945) was found to have good activity versus wild-type

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d4a28c47aced1fff65c6eded613496
https://doi.org/10.1021/jm990383f

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The Oxazolidinone Linezolid Inhibits Initiation of Protein Synthesis in Bacteria

Autor: Dean L. Shinabarger, M C Ganoza, S M Swaney, Hiroyuki Aoki

Publikováno v: Antimicrobial Agents and Chemotherapy. 42:3251-3255

The oxazolidinones represent a new class of antimicrobial agents which are active against multidrug-resistant staphylococci, streptococci, and enterococci. Previous studies have demonstrated that oxazolidinones inhibit bacterial translation in vitro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d54877c4406eea85d4e9a8285f221d8e
https://doi.org/10.1128/aac.42.12.3251

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Pyrimidine Thioethers: A Novel Class of HIV-1 Reverse Transcriptase Inhibitors with Activity Against BHAP-Resistant HIV

Autor: Stephen T. Schlachter, Richard C. Thomas, T. J. Poel, David R. Graber, Robert A. Olmsted, Laurice A. Kopta, Megan Murphy, Richard A. Nugent, S M Swaney, Keiser Bj, Joel Morris, Y. Yagi, Cleek Gary J, W G Tarpley, S M Poppe, Donn G. Wishka

Publikováno v: Journal of Medicinal Chemistry. 41:3793-3803

A series of pyrimidine thioethers was synthesized and evaluated for inhibitory properties against wild-type HIV-1 reverse transcriptase (RT) and an RT carrying the resistance-conferring mutation P236L. Modifications of both the pyrimidine and the fun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4261683cacd8cb18181116f242af220
https://doi.org/10.1021/jm9800806

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An active recombinant p15 RNase H domain is functionally distinct from the RNase H domain associated with human immunodeficiency virus type 1 reverse transcriptase

Autor: W. G. Tarpley, Satish K. Sharma, Naisheng Fan, David B. Evans, S. M. Swaney

Publikováno v: Journal of Biological Chemistry. 269:21741-21747

An active p15 RNase H domain, consisting of amino acids 427-560 of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) and a genetically engineered penta-histidine N-terminal affinity tag, was expressed in Escherichia coli and puri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::86b8c0517c7f28e235e1f83bed7c7980
https://doi.org/10.1016/s0021-9258(17)31867-7

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U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication

Autor: Mariano Busso, Donna Lee Romero, T J Dueweke, Kathleen M. Downey, S. M. Swaney, Lionel Resnick, S M Poppe, Fritz Reusser, Antero G. So, Irene W. Althaus

Publikováno v: Antimicrobial Agents and Chemotherapy. 37:1127-1131

Bisheteroarylpiperazines are potent inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT). We describe a novel bisheteroarylpiperazine, U-90152 [1-(5-methanesulfonamido-1H-indol-2-yl-carbonyl)-4-[3-(1-methyl eth yl-amin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5071316058796b443c9e591414b0d9af
https://doi.org/10.1128/aac.37.5.1127

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A mutation in reverse transcriptase of bis(heteroaryl)piperazine-resistant human immunodeficiency virus type 1 that confers increased sensitivity to other nonnucleoside inhibitors

Autor: W. G. Tarpley, J. Q. Zhao, S M Poppe, I. S. Y. Chen, T J Dueweke, Mario Stevenson, S. M. Swaney, T. Pushkarskaya

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 90(10)

Several nonnucleoside inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) have been described, including Nevirapine, thiobenzimidazolone (TIBO) derivatives, pyridinone derivatives such as L-697,661, and the bis(hetero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad357fc0ee363cdf6a79598ee994af4
https://pubmed.ncbi.nlm.nih.gov/7685109

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