Výsledky vyhledávání - "S. M. Lanier"

Group II activators of G-protein signalling and proteins containing a G-protein regulatory motif

Autor: J B, Blumer, S S, Oner, S M, Lanier

Publikováno v: Acta physiologica (Oxford, England). 204(2)

Beyond the core triad of receptor, Gαβγ and effector, there are multiple accessory proteins that provide alternative modes of signal input and regulatory adaptability to G-protein signalling systems. Such accessory proteins may segregate a signall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d997933b815052f95881af0c0f61b7b6
https://pubmed.ncbi.nlm.nih.gov/21615707

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Factors determining the specificity of signal transduction by guanine nucleotide-binding protein-coupled receptors. I. Coupling of alpha 2-adrenergic receptor subtypes to distinct G-proteins

Autor: S M Lanier, E Duzic, I Coupry, S Downing

Publikováno v: Journal of Biological Chemistry. 267:9844-9851

alpha 2-Adrenergic receptor (alpha 2-AR) subtypes couple to pertussis toxin (PT)-sensitive G-proteins to elicit both stimulatory and inhibitory cell responses. Signal specificity may be generated by the ability of the receptor subtypes to "recognize"

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0bb5d30a6c227154211c7c12e96dfd69
https://doi.org/10.1016/s0021-9258(19)50171-5

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Factors determining the specificity of signal transduction by guanine nucleotide-binding protein-coupled receptors. II. Preferential coupling of the alpha 2C-adrenergic receptor to the guanine nucleotide-binding protein, Go

Autor: E Duzic, S M Lanier, I Coupry

Publikováno v: Journal of Biological Chemistry. 267:9852-9857

Cell to cell communication by many hormones and neurotransmitters involves three major entities: receptor (R), G-protein (G), and effector molecule (E). Plasticity in this system is conferred by the existence of each entity as isoforms or closely rel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::464bafdf11f4449fc96701d526918268
https://doi.org/10.1016/s0021-9258(19)50172-7

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Isolation of rat genomic clones encoding subtypes of the alpha 2-adrenergic receptor. Identification of a unique receptor subtype

Autor: C J Homcy, E Duzic, S Downing, S M Lanier

Publikováno v: Journal of Biological Chemistry. 266:10470-10478

alpha 2-Adrenergic receptors (alpha 2-AR) exist as subtypes that are expressed in a tissue-specific manner and differ in 1) their ligand recognition properties, 2) their extent of receptor protein glycosylation, and possible 3) their mechanism of sig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a60338e8f8db1ff84f130644cb0cdb1b
https://doi.org/10.1016/s0021-9258(18)99248-3

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Activation of heterotrimeric G-proteins independent of a G-protein coupled receptor and the implications for signal processing

Autor: M. J. Cismowski, S. M. Lanier

Publikováno v: Reviews of Physiology Biochemistry and Pharmacology ISBN: 3540281924

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b40eb38f291b292b039a7da1f1a1151
https://doi.org/10.1007/3-540-28217-3_3

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Activation of heterotrimeric G-proteins independent of a G-protein coupled receptor and the implications for signal processing

Autor: M J, Cismowski, S M, Lanier

Publikováno v: Reviews of physiology, biochemistry and pharmacology. 155

Heterotrimeric G-proteins are key transducers for signal transfer from outside the cell, mediating signals emanating from cell-surface G-protein coupled receptors (GPCR). Many, if not all, subtypes of heterotrimeric G-proteins are also regulated by a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f0279f0b8ad3c618f0b6d16e5ff1b493
https://pubmed.ncbi.nlm.nih.gov/16041530

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Activation of heterotrimeric G-proteins independent of a G-protein coupled receptor and the implications for signal processing

Autor: S. M. Lanier, M. J. Cismowski

Publikováno v: Reviews of Physiology, Biochemistry and Pharmacology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a6de86ddd5ee4f95ddcf6818051c46a8
https://doi.org/10.1007/s10254-005-0042-z

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Activation of heterotrimeric G-protein signaling by a ras-related protein. Implications for signal integration

Autor: M J, Cismowski, C, Ma, C, Ribas, X, Xie, M, Spruyt, J S, Lizano, S M, Lanier, E, Duzic

Publikováno v: The Journal of biological chemistry. 275(31)

Utilizing a functional screen in the yeast Saccharomyces cerevisiae we identified mammalian proteins that activate heterotrimeric G-protein signaling pathways in a receptor-independent fashion. One of the identified activators, termed AGS1 (for activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::96eda9e471e38ed279fee0bf20250d68
https://pubmed.ncbi.nlm.nih.gov/10840027

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Imidazoline-binding domains on monoamine oxidase B and subpopulations of enzyme

Autor: R, Raddatz, S L, Savic, V, Bakthavachalam, J, Lesnick, J R, Jasper, C R, McGrath, A, Parini, S M, Lanier

Publikováno v: The Journal of pharmacology and experimental therapeutics. 292(3)

A series of phenoxy-substituted methylimidazoline derivatives were synthesized and used to define the ligand recognition properties of the imidazoline-binding domain (IBD) on monoamine oxidase (MAO)-B and its role in substrate processing. The rank or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1287bdd94fbf4be3836f30d5d7129431
https://pubmed.ncbi.nlm.nih.gov/10688633

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