Zobrazeno 1 - 10 of 29 pro vyhledávání: '"S. M. Freier"'
1
Synthesis of 2′-O-methyl-6,3′-ethanouridine and its introduction into antisense oligonucleotides
Autor: S. M. Freier, Romain M. Wolf, Marc‐Olivier Bévièrre, Alain De Mesmaeker
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 4:237-240
A molecular modelling study and a synthesis of title compound 1 are presented. This novel modified nucleoside was introduced into different oligonucleotides and the corresponding melting temperatures of the duplexes formed with the complementary RNA
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::13b5e1751ee2e50ffc2ff96d8a88c503
https://doi.org/10.1016/s0960-894x(01)80121-9
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2
Synthesis of thymidine dimer derivatives containing an amide linkage and their incorporation into oligodeoxyribonucleotides
Autor: Alain De Mesmaeker, R. M. Wolf, S. M. Freier, A. Waldner, Jacques Lebreton, Valérie Fritsch
Publikováno v: Tetrahedron Letters. 34:6383-6386
The syntheses of thymidine dimers in which the natural phosphodiester linkage has been replaced by an amide group (3′-NR-CO-CH 2 -5′; R=H, Me, n-Pr) are described. These new dimers were incorporated into oligonucleotides. Measurement of melting t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1a40a002316cebd438a2465b2358ff0c
https://doi.org/10.1016/0040-4039(93)85051-w
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