Zobrazeno 1 - 10
of 566
pro vyhledávání: '"S. M. Dennis"'
Autor:
Deyun Qiu, Jinxin V. Pei, James E. O. Rosling, Vandana Thathy, Dongdi Li, Yi Xue, John D. Tanner, Jocelyn Sietsma Penington, Yi Tong Vincent Aw, Jessica Yi Han Aw, Guoyue Xu, Abhai K. Tripathi, Nina F. Gnadig, Tomas Yeo, Kate J. Fairhurst, Barbara H. Stokes, James M. Murithi, Krittikorn Kümpornsin, Heath Hasemer, Adelaide S. M. Dennis, Melanie C. Ridgway, Esther K. Schmitt, Judith Straimer, Anthony T. Papenfuss, Marcus C. S. Lee, Ben Corry, Photini Sinnis, David A. Fidock, Giel G. van Dooren, Kiaran Kirk, Adele M. Lehane
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
In a recent clinical trial for oral administration of cipargamin in individuals with malaria, there was an emergence of recrudescent parasites with a G358S mutation in PfATP4. In this work, the authors investigate the effect of this mutation on the f
Externí odkaz:
https://doaj.org/article/7abacde286514d8b929ffa3fbc4d3a0f
Akademický článek
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Autor:
Alice E. Williamson, Paul M. Ylioja, Murray N. Robertson, Yevgeniya Antonova-Koch, Vicky Avery, Jonathan B. Baell, Harikrishna Batchu, Sanjay Batra, Jeremy N. Burrows, Soumya Bhattacharyya, Felix Calderon, Susan A. Charman, Julie Clark, Benigno Crespo, Matin Dean, Stefan L. Debbert, Michael Delves, Adelaide S. M. Dennis, Frederik Deroose, Sandra Duffy, Sabine Fletcher, Guri Giaever, Irene Hallyburton, Francisco-Javier Gamo, Marinella Gebbia, R. Kiplin Guy, Zoe Hungerford, Kiaran Kirk, Maria J. Lafuente-Monasterio, Anna Lee, Stephan Meister, Corey Nislow, John P. Overington, George Papadatos, Luc Patiny, James Pham, Stuart A. Ralph, Andrea Ruecker, Eileen Ryan, Christopher Southan, Kumkum Srivastava, Chris Swain, Matthew J. Tarnowski, Patrick Thomson, Peter Turner, Iain M. Wallace, Timothy N. C. Wells, Karen White, Laura White, Paul Willis, Elizabeth A. Winzeler, Sergio Wittlin, Matthew H. Todd
Publikováno v:
ACS Central Science, Vol 2, Iss 10, Pp 687-701 (2016)
Externí odkaz:
https://doaj.org/article/389f0d71ee2a4fb79f8bb1da8028bfae
Autor:
Sanduni V Hapuarachchi, Simon A Cobbold, Sarah H Shafik, Adelaide S M Dennis, Malcolm J McConville, Rowena E Martin, Kiaran Kirk, Adele M Lehane
Publikováno v:
PLoS Pathogens, Vol 13, Iss 2, p e1006180 (2017)
In this study the 'Malaria Box' chemical library comprising 400 compounds with antiplasmodial activity was screened for compounds that perturb the internal pH of the malaria parasite, Plasmodium falciparum. Fifteen compounds induced an acidification
Externí odkaz:
https://doaj.org/article/af29320f19f24b8b9d2b5dfd5482a5da
Publikováno v:
Nigerian Journal of Animal Production. 6:41-46
THE effect of bone meal supplementation on pregnancy and plasma phosphorus level in White Fulani (Bunaji) cattle was investigated over a 13-month period. The monthly mean plasma levels of inorganic phosphorus for supplemented Cows varied from 4.63mg/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb80de4bc389c0215fa648b7165b7729
https://doi.org/10.51791/njap.v6i.2656
https://doi.org/10.51791/njap.v6i.2656
Autor:
Deyun Qiu, Jinxin V. Pei, James E. O. Rosling, Dongdi Li, Yi Xue, Jocelyn Sietsma Penington, Krittikorn Kümpornsin, Yi Tong Vincent Aw, Jessica Yi Han Aw, Heath Hasemer, Adelaide S. M. Dennis, Melanie C. Ridgway, Anthony T. Papenfuss, Marcus C. S. Lee, Giel G. van Dooren, Kiaran Kirk, Adele M. Lehane
Small-molecule inhibitors of PfATP4, a Plasmodium falciparum protein that is believed to pump Na+ out of the parasite while importing H+, are on track to become much-needed new antimalarial drugs. The spiroindolone cipargamin is poised to become the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60fbce80d8893b9d3de3dceeed4f1978
https://doi.org/10.1101/2022.01.11.475938
https://doi.org/10.1101/2022.01.11.475938
Publikováno v:
Higher Education Research & Development. 38:1154-1167
This study is an autoethnographic reflection on power and expertise in an evolving student/staff partnership. The partnership was initiated as pedagogical co-design in the development and i...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8d945d64b428a0154364701d96b3f66
https://doi.org/10.1080/07294360.2019.1621270
https://doi.org/10.1080/07294360.2019.1621270
Autor:
Dongdi Li, Farid Rahimi, Katherine O. Bray, Adelaide S. M. Dennis, Kiaran Kirk, Christopher J. Tonkin, Adele M. Lehane, Giel G. van Dooren, Hillary M. McArthur, Markus Winterberg, Esther Rajendran, James M. McCoy
The Plasmodium falciparum ATPase PfATP4 is the target of a diverse range of antimalarial compounds, including the clinical drug candidate cipargamin. PfATP4 was originally annotated as a Ca2+ transporter, but recent evidence suggests that it is a Na+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6c8f2bca6ccf2513a50523e53615ecb
https://doi.org/10.1074/jbc.ra118.006706
https://doi.org/10.1074/jbc.ra118.006706
Publikováno v:
Antimicrobial Agents and Chemotherapy. 62
For an increasing number of antimalarial agents identified in high-throughput phenotypic screens, there is evidence that they target PfATP4, a putative Na + efflux transporter on the plasma membrane of the human malaria parasite Plasmodium falciparum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9be98607b4f96735597f1236974cc703
https://doi.org/10.1128/aac.00087-18
https://doi.org/10.1128/aac.00087-18
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Four hundred structurally diverse drug-like compounds comprising the Medicines for Malaria Venture’s ‘Pathogen Box’ were screened for their effect on a range of physiological parameters in asexual blood-stage malaria (Plasmodium falciparum) par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dcc2b2009aeaabace36e58494ab6803
https://pubmed.ncbi.nlm.nih.gov/29892073
https://pubmed.ncbi.nlm.nih.gov/29892073