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Akademický článek

Epetraborole, a leucyl-tRNA synthetase inhibitor, demonstrates murine efficacy, enhancing the in vivo activity of ceftazidime against Burkholderia pseudomallei, the causative agent of melioidosis.

Autor: Jason E Cummings, Christopher S Lunde, M R K Alley, Richard A Slayden

Publikováno v: PLoS Neglected Tropical Diseases, Vol 17, Iss 11, p e0011795 (2023)

Burkholderia pseudomallei is the causative agent of melioidosis, which is increasingly being reported worldwide. Mortality rates as high as 40% have been reported based on clinical patient outcomes in the endemic areas of Australia and Thailand. Nove

Externí odkaz: https://doaj.org/article/507864f1f55e4eee9340ff09864717bb

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Akademický článek

Evolutionary, comparative, and functional analyses of STATs and regulation of the JAK-STAT pathway in lumpfish upon bacterial and poly(I:C) exposure

Autor: Shreesha S. Rao, Patrick A. Nelson, Harald S. Lunde, Gyri T. Haugland

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)

BackgroundThe Janus kinase/signal transducers and activators of transcription (JAK-STAT) system regulates several biological processes by affecting transcription of genes as a response to cytokines and growth factors. In the present study, we have ch

Externí odkaz: https://doaj.org/article/fdb0cfc61f60418eba3598224d7c966d

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Akademický článek

Transcriptome-wide analyses of early immune responses in lumpfish leukocytes upon stimulation with poly(I:C)

Autor: Shreesha S. Rao, Harald S. Lunde, David W. P. Dolan, Amanda K. Fond, Kjell Petersen, Gyri T. Haugland

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

BackgroundBoth bacterial and viral diseases are a major threat to farmed fish. As the antiviral immune mechanisms in lumpfish (Cyclopterus lumpus L.) are poorly understood, lumpfish leukocytes were stimulated with poly(I:C), a synthetic analog of dou

Externí odkaz: https://doaj.org/article/c00b7dd2261a458ba07545e37acd521a

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Akademický článek

From BeyondPlanck to Cosmoglobe: Open Science, Reproducibility, and Data Longevity

Publikováno v: The Open Journal of Astrophysics, Vol 6 (2023)

The BeyondPlanck and Cosmoglobe collaborations have implemented the first integrated Bayesian end-to-end analysis pipeline for CMB experiments. The primary long-term motivation for this work is to develop a common analysis platform that supports effi

Externí odkaz: https://doaj.org/article/0af24e67aebb439cb6fe74515811a83b

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Akademický článek

Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis

Autor: Christopher S. Lunde, Erin E. Stebbins, Rajiv S. Jumani, Md Mahmudul Hasan, Peter Miller, John Barlow, Yvonne R. Freund, Pamela Berry, Rianna Stefanakis, Jiri Gut, Philip J. Rosenthal, Melissa S. Love, Case W. McNamara, Eric Easom, Jacob J. Plattner, Robert T. Jacobs, Christopher D. Huston

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)

Cryptosporidium infection can cause severe diarrhea with limited treatment options available. Here, Lunde et al. perform a drug repositioning screen with a library of benzoxaboroles and identify AN7973 as potent inhibitor of intracellular parasite de

Externí odkaz: https://doaj.org/article/9ffc28868e0b404a868e8f4e98e9bbf7

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