Zobrazeno 1 - 10
of 22
pro vyhledávání: '"S. Louise Pay"'
Autor:
Colton L. Starcher, S. Louise Pay, Naveen Singh, I-Ju Yeh, Snehal B. Bhandare, Xiaolin Su, Xiumei Huang, Erik A. Bey, Edward A. Motea, David A. Boothman
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Ionizing radiation (IR) creates lethal DNA damage that can effectively kill tumor cells. However, the high dose required for a therapeutic outcome also damages healthy tissue. Thus, a therapeutic strategy with predictive biomarkers to enhance the ben
Externí odkaz:
https://doaj.org/article/a9f93e68362c453783961f81542a9d68
Autor:
David A. Boothman, S. Louise Pay, I-Ju Yeh, Erik A. Bey, Edward A. Motea, Colton L. Starcher, Xiaolin Su, Naveen Singh, Xiumei Huang, Snehal B. Bhandare
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Frontiers in Oncology
Frontiers in Oncology
Ionizing radiation (IR) creates lethal DNA damage that can effectively kill tumor cells. However, the high dose required for a therapeutic outcome also damages healthy tissue. Thus, a therapeutic strategy with predictive biomarkers to enhance the ben
Publikováno v:
Cancers, Vol 12, Iss 972, p 972 (2020)
Cancers
Cancers
Poly-(ADP-ribose) polymerase 1 (PARP1) is commonly known for its vital role in DNA damage response and repair. However, its enzymatic activity has been linked to a plethora of physiological and pathophysiological transactions ranging from cellular pr
Autor:
Edward A. Motea, Jayne Silver, Xiumei Huang, Colton L. Starcher, Naveen Singh, Kristen A. Russ, Erik A. Bey, David A. Boothman, Xiaolin Su, I-Ju Yeh, S. Louise Pay
Developing cancer therapeutics that radiosensitize in a tumor-selective manner remains an ideal. We developed a novel means of radiosensitization, exploiting NAD(P)H:Quinone Oxidoreductase 1 (NQO1) overexpression, and lowered catalase expression in s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c4d95118b3595fd8733bd57d248ebe8
http://www.intechopen.com/articles/show/title/nqo1-bioactivatable-therapeutics-as-radiosensitizers-for-cancer-treatment
http://www.intechopen.com/articles/show/title/nqo1-bioactivatable-therapeutics-as-radiosensitizers-for-cancer-treatment
Autor:
Michael E. Boulton, Sayak K. Mitter, Judith Quigley, S. Louise Pay, Kavya Sankhavaram, Juliana Godoy, Maria B. Grant, Jeffrey F. Willard, Lung-Ji Chang, Ranier Horton, Xiaoping Qi
Publikováno v:
Human Gene Therapy Methods
In lentiviral vector (LV) applications where transient transgene expression is sufficient, integrase-defective lentiviral vectors (IDLVs) are beneficial for reducing the potential for off-target effects associated with insertional mutagenesis. It was
Autor:
Momoko Yoshimoto, Zoya Plotkin, Bernhard F. Maier, Takashi Hato, Pablo D. Cabral, S. Louise Pay, Amy Zollman, Pierre C. Dagher, Tarek M. El-Achkar, Jeanette N. McClintick, Shataakshi Dube
Publikováno v:
Journal of the American Society of Nephrology. 29:104-117
Preconditioning with a low dose of endotoxin confers unparalleled protection against otherwise lethal models of sepsis. The mechanisms of preconditioning have been investigated extensively in isolated immune cells such as macrophages. However, the ro
Autor:
S. Louise Pay, Lung-Ji Chang, Xiaoping Qi, Michael E. Boulton, James D. Thomas, Yuanqing Yan, Maria B. Grant, Alfred S. Lewin
Publikováno v:
Molecular Therapy. 25:917-927
Bone marrow stem and progenitor cells can differentiate into a range of non-hematopoietic cell types, including retinal pigment epithelium (RPE)-like cells. In this study, we programmed bone marrow-derived cells (BMDCs) ex vivo by inserting a stable
Autor:
EJun Yun, Bruce A. Molitoris, Ruben M. Sandoval, Amy Zollman, Bernhard F. Maier, Takashi Hato, John Avera, Masaki Uchida, Trevor Douglas, S. Louise Pay, Ekaterina Selivanovitch, Hitesh Kumar Waghwani
Nature exploits cage-like proteins for a variety of biological purposes, from molecular packaging and cargo delivery to catalysis. These cage-like proteins are of immense importance in nanomedicine due to their propensity to self-assemble from simple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c00f15de350966229e64233c11c773f4
https://europepmc.org/articles/PMC6715384/
https://europepmc.org/articles/PMC6715384/
Autor:
Megan M. Schellinger, Emily K. Blue, Helmut Hanenberg, Julie A. Mund, Ethel Derr-Yellin, S. Louise Pay, Sara K. Quinney, Juan Carlos Acosta, Robert DiGiuseppe, Laura S. Haneline, Jamie Case
Publikováno v:
Pediatric research
Children born to mothers with gestational diabetes mellitus (GDM) experience increased risk of developing hypertension, type 2 diabetes mellitus, and obesity. Disrupted function of endothelial colony-forming cells (ECFCs) may contribute to this enhan
Autor:
Qingwen, Qian, Sayak K, Mitter, S Louise, Pay, Xiaoping, Qi, Catherine Bowes, Rickman, Maria B, Grant, Michael E, Boulton
Publikováno v:
Advances in experimental medicine and biology. 854
It has long been established that β-Secretase (BACE) plays a critical role in the formation of amyloid plaques in Alzheimer's Disease patients, but it is only recently that the importance of β-secretases in retinal pathophysiology has been recogniz