Zobrazeno 1 - 10
of 1 158
pro vyhledávání: '"S. Leslie"'
Autor:
Vianne R. Gao, Rui Yang, Arnav Das, Renhe Luo, Hanzhi Luo, Dylan R. McNally, Ioannis Karagiannidis, Martin A. Rivas, Zhong-Min Wang, Darko Barisic, Alireza Karbalayghareh, Wilfred Wong, Yingqian A. Zhan, Christopher R. Chin, William S. Noble, Jeff A. Bilmes, Effie Apostolou, Michael G. Kharas, Wendy Béguelin, Aaron D. Viny, Danwei Huangfu, Alexander Y. Rudensky, Ari M. Melnick, Christina S. Leslie
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Identifying cell-type-specific 3D chromatin interactions between regulatory elements can help decipher gene regulation and interpret disease-associated non-coding variants. However, achieving this resolution with current 3D genomics technolo
Externí odkaz:
https://doaj.org/article/9058f5eecd4a4599ae65bc3feace0303
Autor:
S. R. Willoughby, S. Rajendran, W. P. Chan, N. Procter, S. Leslie, E. A. Liberts, T. Heresztyn, Y. Y. Chirkov, J. D. Horowitz
Publikováno v:
Рациональная фармакотерапия в кардиологии, Vol 8, Iss 4, Pp 595-603 (2015)
Цель. Целями настоящей работы, в которую вошли 2 последовательных исследования в группе больных с высоким сердечно-сосудистым риском с к
Externí odkaz:
https://doaj.org/article/cd841685de0f470896bda7a56583680e
Autor:
Samuel Joseph Kaplan, Wilfred Wong, Jielin Yan, Julian Pulecio, Hyein S. Cho, Qianzi Li, Jiahui Zhao, Jayanti Leslie-Iyer, Jonathan Kazakov, Dylan Murphy, Renhe Luo, Kushal K. Dey, Effie Apostolou, Christina S. Leslie, Danwei Huangfu
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114640- (2024)
Summary: Functional enhancer annotation is critical for understanding tissue-specific transcriptional regulation and prioritizing disease-associated non-coding variants. However, unbiased enhancer discovery in disease-relevant contexts remains challe
Externí odkaz:
https://doaj.org/article/18884ea54402465ca393dbb1bcd2118f
Publikováno v:
Signals, Vol 5, Iss 1, Pp 40-59 (2024)
We consider the challenge of detecting and clustering point and collective anomalies in streaming data that exhibit significant nonlinearities and seasonal structures. The challenge is motivated by detecting problems in a communications network, wher
Externí odkaz:
https://doaj.org/article/e62ffa92987d42f9bf739ffefb9dde72
Autor:
Rui Yang, Arnav Das, Vianne R. Gao, Alireza Karbalayghareh, William S. Noble, Jeffrey A. Bilmes, Christina S. Leslie
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-26 (2023)
Abstract Recent deep learning models that predict the Hi-C contact map from DNA sequence achieve promising accuracy but cannot generalize to new cell types and or even capture differences among training cell types. We propose Epiphany, a neural netwo
Externí odkaz:
https://doaj.org/article/03e9075f1972485484f1aafb6af44eb5
Publikováno v:
JAAD Case Reports, Vol 35, Iss , Pp 98-102 (2023)
Externí odkaz:
https://doaj.org/article/afea68895fab4aa8ad6bff70cf34b6bd
Autor:
Rui Yang, Arnav Das, Vianne R. Gao, Alireza Karbalayghareh, William S. Noble, Jeffrey A. Bilmes, Christina S. Leslie
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/9e27b8675a2a42da9d2482ac953dcd45
Publikováno v:
JAAD Case Reports, Vol 32, Iss , Pp 84-87 (2023)
Externí odkaz:
https://doaj.org/article/b6a4dc3314354939961f48385397e8a0
Autor:
Siying Lin, Aida Sanchez-Bretaño, Joseph S. Leslie, Katie B. Williams, Helena Lee, N. Simon Thomas, Jonathan Callaway, James Deline, J. Arjuna Ratnayaka, Diana Baralle, Melanie A. Schmitt, Chelsea S. Norman, Sheri Hammond, Gaurav V. Harlalka, Sarah Ennis, Harold E. Cross, Olivia Wenger, Andrew H. Crosby, Emma L. Baple, Jay E. Self
Publikováno v:
npj Genomic Medicine, Vol 7, Iss 1, Pp 1-11 (2022)
Abstract Oculocutaneous albinism type 1 (OCA1) is caused by pathogenic variants in the TYR (tyrosinase) gene which encodes the critical and rate-limiting enzyme in melanin synthesis. It is the most common OCA subtype found in Caucasians, accounting f
Externí odkaz:
https://doaj.org/article/8ddc9109fec74dd780fb8658772b15c8
Autor:
Yuchen Xie, Merve Sahin, Toru Wakamatsu, Akane Inoue-Yamauchi, Wanming Zhao, Song Han, Amrita M. Nargund, Shaoyuan Yang, Yang Lyu, James J. Hsieh, Christina S. Leslie, Emily H. Cheng
Publikováno v:
JCI Insight, Vol 8, Iss 4 (2023)
SETD2, a H3K36 trimethyltransferase, is the most frequently mutated epigenetic modifier in lung adenocarcinoma, with a mutation frequency of approximately 9%. However, how SETD2 loss of function promotes tumorigenesis remains unclear. Using condition
Externí odkaz:
https://doaj.org/article/609d7648d45a4ebb9f934f1c8a5d9339