Výsledky vyhledávání

Leptomycin B stabilizes and activates p53 in primary prostatic epithelial cells and induces apoptosis in the LNCaP cell line

Autor: Philip S. Lecane, Taija M. Kiviharju, Donna M. Peehl, Robert G. Sellers

Publikováno v: The Prostate. 54:258-267

Background Previous studies showed that primary cultures of normal and malignant human prostatic epithelial cells are defective in their ability to upregulate the tumor suppressor protein p53 in response to DNA damage. This dysfunctional regulation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b3ae92e97397f14910d36d7611280b9
https://doi.org/10.1002/pros.10197

Zobrazit plný text záznamu

Overexpression of Wild-Type p53 and c-Myc in Human Fetal Cells Transformed with Adenovirus Early Region 1

Autor: Sally Roberts, Christopher W. Dawson, Phillip H. Gallimore, Michael L. Grant, David P. Lane, Roger J.A. Grand, Philip S. Lecane, Lawrence S. Young

Publikováno v: Virology. 193:579-591

The expression of p53 in a large panel of adenovirus (Ad) 2/5- and 12-transformed human, rat, and mouse cells has been examined. In all cases, in the absence of the larger Ad E1B protein, the level of p53 is very low. In human and rat cells when the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75a0427342b9528f2ff9fc7f07a7e1cf
https://doi.org/10.1006/viro.1993.1166

Zobrazit plný text záznamu

Targeting hypoxic cells through the DNA damage response

Autor: Monica M. Olcina, Philip S. Lecane, Ester M. Hammond

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 16(23)

Exposure to hypoxia-induced replication arrest initiates a DNA damage response that includes both ATR- and ATM-mediated signaling. DNA fiber analysis was used to show that these conditions lead to a replication arrest during both the initiation and e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48cfc342913065c0821d32f4b4b4ff84
http://ora.ox.ac.uk/objects/uuid:d9c472a7-1f32-4942-ab72-319bce9577a2

Zobrazit plný text záznamu

ATM activation and signaling under hypoxic conditions

Autor: Philip S. Lecane, Zuzana Bencokova, Isabel M. Pires, Amato J. Giaccia, Ester M. Hammond, Muriel R. Kaufmann

Publikováno v: Bencokova, Z, Kaufmann, MR, Pires, IM, Lecane, PS, Giaccia, AJ & Hammond, EM 2009, ' ATM activation and signaling under hypoxic conditions ', Molecular and Cellular Biology, vol. 29, no. 2, pp. 526-537 . https://doi.org/10.1128/MCB.01301-08

The ATM kinase has previously been shown to respond to the DNA damage induced by reoxygenation following hypoxia by initiating a Chk 2-dependent cell cycle arrest in the G(2) phase. Here we show that ATM is both phosphorylated and active during expos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5670abd15625d61c4f3341f3a380b914
http://ora.ox.ac.uk/objects/uuid:3e099c07-a145-4009-96c3-889662ce9836

Zobrazit plný text záznamu

Rotenone-induced G2/M cell cycle arrest and apoptosis in a human B lymphoma cell line PW

Autor: Dean P. Jones, Susan J. Knox, Brita Hornung, Jeffrey S. Armstrong, Philip S. Lecane

Publikováno v: Biochemical and biophysical research communications. 289(5)

Concentrations of rotenone (ROT) that block electron flow through mitochondrial complex I (100 nM) did not significantly alter either cell viability or the growth of PW cells. However, 10- to 50-fold higher concentrations (1–5 μM) were found to in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af14f0aeaa84e46fb204ed012a1bcfd0
https://pubmed.ncbi.nlm.nih.gov/11741286

Zobrazit plný text záznamu

Role of glutathione depletion and reactive oxygen species generation in apoptotic signaling in a human B lymphoma cell line

Autor: Geoff W. Birrell, B Hornung, Donna M. Peehl, Kirsten K Steinauer, Susan J. Knox, Jeffrey S. Armstrong, Jonathan M. Irish, Philip S. Lecane

Publikováno v: Cell death and differentiation. 9(3)

The primary objective of this study was to determine the sequence of biochemical signaling events that occur after modulation of the cellular redox state in the B cell lymphoma line, PW, with emphasis on the role of mitochondrial signaling. L-Buthion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a341b8b517cb66981da1e807a4c5e7
https://pubmed.ncbi.nlm.nih.gov/11859408

Zobrazit plný text záznamu

Differentiation is inhibited and a senescence pathway is activated when simian virus 40 tsA 58-transformed human retinoblasts are grown at the restrictive temperature

Autor: P H, Gallimore, P S, Lecane, B, Hann, R J, Grand

Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 8(7)

Neonatal human retina cells transformed by the SV40 tumor antigens were shown to leave the cell cycle and differentiate following treatment with agents that raise intracellular levels of cyclic AMP. This was true for both precrisis and immortal cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::210a2e0c625441be5b224ea41be55689
https://pubmed.ncbi.nlm.nih.gov/9218870

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání