Leptomycin B stabilizes and activates p53 in primary prostatic epithelial cells and induces apoptosis in the LNCaP cell line

Autor: Philip S. Lecane, Taija M. Kiviharju, Donna M. Peehl, Robert G. Sellers

Publikováno v: The Prostate. 54:258-267

Background Previous studies showed that primary cultures of normal and malignant human prostatic epithelial cells are defective in their ability to upregulate the tumor suppressor protein p53 in response to DNA damage. This dysfunctional regulation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b3ae92e97397f14910d36d7611280b9
https://doi.org/10.1002/pros.10197

Overexpression of Wild-Type p53 and c-Myc in Human Fetal Cells Transformed with Adenovirus Early Region 1

Autor: Sally Roberts, Christopher W. Dawson, Phillip H. Gallimore, Michael L. Grant, David P. Lane, Roger J.A. Grand, Philip S. Lecane, Lawrence S. Young

Publikováno v: Virology. 193:579-591

The expression of p53 in a large panel of adenovirus (Ad) 2/5- and 12-transformed human, rat, and mouse cells has been examined. In all cases, in the absence of the larger Ad E1B protein, the level of p53 is very low. In human and rat cells when the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75a0427342b9528f2ff9fc7f07a7e1cf
https://doi.org/10.1006/viro.1993.1166

ATM activation and signaling under hypoxic conditions

Autor: Philip S. Lecane, Zuzana Bencokova, Isabel M. Pires, Amato J. Giaccia, Ester M. Hammond, Muriel R. Kaufmann

Publikováno v: Bencokova, Z, Kaufmann, MR, Pires, IM, Lecane, PS, Giaccia, AJ & Hammond, EM 2009, ' ATM activation and signaling under hypoxic conditions ', Molecular and Cellular Biology, vol. 29, no. 2, pp. 526-537 . https://doi.org/10.1128/MCB.01301-08

The ATM kinase has previously been shown to respond to the DNA damage induced by reoxygenation following hypoxia by initiating a Chk 2-dependent cell cycle arrest in the G(2) phase. Here we show that ATM is both phosphorylated and active during expos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5670abd15625d61c4f3341f3a380b914
http://ora.ox.ac.uk/objects/uuid:3e099c07-a145-4009-96c3-889662ce9836

Role of glutathione depletion and reactive oxygen species generation in apoptotic signaling in a human B lymphoma cell line

Autor: Geoff W. Birrell, B Hornung, Donna M. Peehl, Kirsten K Steinauer, Susan J. Knox, Jeffrey S. Armstrong, Jonathan M. Irish, Philip S. Lecane

Publikováno v: Cell death and differentiation. 9(3)

The primary objective of this study was to determine the sequence of biochemical signaling events that occur after modulation of the cellular redox state in the B cell lymphoma line, PW, with emphasis on the role of mitochondrial signaling. L-Buthion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a341b8b517cb66981da1e807a4c5e7
https://pubmed.ncbi.nlm.nih.gov/11859408

The high levels of p53 present in adenovirus early region 1-transformed human cells do not cause up-regulation of MDM2 expression

Autor: Arnold J. Levine, Phillip H. Gallimore, Roger J.A. Grand, Darerca Owen, Philip S. Lecane, Michael L. Grant, Sally Roberts

Publikováno v: Virology. 210(2)

The cellular protein MDM2 can bind to the tumor suppressor gene product p53 and abrogate its transcriptional activity. In addition, p53 can regulate expression of the mdm2 gene. We and others have previously shown that p53 is present at high levels i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23c388cbc8f09ca21af0b941483e0284
https://pubmed.ncbi.nlm.nih.gov/7618270