Zobrazeno 1 - 10
of 599
pro vyhledávání: '"S. Latimer"'
Autor:
R. M. Walker, W. Chaboyer, M. Cooke, J. A. Whitty, L. Thalib, I. Lockwood, S. Latimer, J. Campbell, R. Probert, B. M. Gillespie
Publikováno v:
Trials, Vol 24, Iss 1, Pp 1-13 (2023)
Abstract Background Prophylactic dressings are increasingly used to prevent pressure injuries in hospitalised patients. However, evidence regarding the effectiveness of these dressings is still emerging. This trial aims to determine the clinical and
Externí odkaz:
https://doaj.org/article/2f811085239e445aa67c7a56845900bc
Autor:
Pamela J. McMillan, Timothy J. Strovas, Misa Baum, Brooke K. Mitchell, Randall J. Eck, Nzinga Hendricks, Jeanna M. Wheeler, Caitlin S. Latimer, C. Dirk Keene, Brian C. Kraemer
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-14 (2021)
Abstract Several conserved nuclear RNA binding proteins (sut-1, sut-2, and parn-2) control tau aggregation and toxicity in C. elegans, mice, and human cells. MSUT2 protein normally resides in nuclear speckles, membraneless organelles composed of phas
Externí odkaz:
https://doaj.org/article/dd6cabf3bab6402eb83b0235389e890a
Autor:
Caitlin S. Latimer, Jade G. Stair, Joshua C. Hincks, Heather N. Currey, Thomas D. Bird, C. Dirk Keene, Brian C. Kraemer, Nicole F. Liachko
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 4 (2022)
Although amyloid β (Aβ) and tau aggregates define the neuropathology of Alzheimer's disease (AD), TDP-43 has recently emerged as a co-morbid pathology in more than half of patients with AD. Individuals with concomitant Aβ, tau and TDP-43 pathology
Externí odkaz:
https://doaj.org/article/5c050bf00fd142a8b69dd0b71acd12dc
Autor:
Xin Wang, Xueyan Zhou, Beth Uberseder, Jingyun Lee, Caitlin S. Latimer, Cristina M. Furdui, C. Dirk Keene, Thomas J. Montine, Thomas C. Register, Suzanne Craft, Carol A. Shively, Tao Ma
Publikováno v:
Neurobiology of Disease, Vol 158, Iss , Pp 105463- (2021)
AMP-activated protein kinase (AMPK) is a molecular sensor that is critical for the maintenance of cellular energy homeostasis, disruption of which has been indicated in multiple neurodegenerative diseases including Alzheimer's disease (AD). Mammalian
Externí odkaz:
https://doaj.org/article/4eef4d5096524db79b93a6bfb430a4c7
Autor:
Jason M. Webster, Thomas J. Grabowski, Tara M. Madhyastha, Laura E. Gibbons, C. Dirk Keene, Caitlin S. Latimer
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
IntroductionThe study of Alzheimer’s disease investigates topographic patterns of degeneration in the context of connected networks comprised of functionally distinct domains using increasingly sophisticated molecular techniques. Therefore, obtaini
Externí odkaz:
https://doaj.org/article/43d99c091745404ab6a2c2f159e95d65
Autor:
Caitlin S. Latimer, Bridget T. Burke, Nicole F. Liachko, Heather N. Currey, Mitchell D. Kilgore, Laura E. Gibbons, Jonathan Henriksen, Martin Darvas, Kimiko Domoto-Reilly, Suman Jayadev, Tom J. Grabowski, Paul K. Crane, Eric B. Larson, Brian C. Kraemer, Thomas D. Bird, C. Dirk Keene
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-24 (2019)
Abstract Alzheimer’s disease neuropathologic change (ADNC) is defined by progressive accumulation of β-amyloid plaques and hyperphosphorylated tau (pTau) neurofibrillary tangles across diverse regions of brain. Non-demented individuals who reach a
Externí odkaz:
https://doaj.org/article/bc0a491ce3824f00984ecbed34fa9ee7
Autor:
Laura E. Gibbons, Melinda C. Power, Rod L. Walker, Raj G. Kumar, Alia Murphy, Caitlin S. Latimer, Amber L. Nolan, Erica J. Melief, Allison Beller, Marika Bogdani, Dirk Keene, Eric B. Larson, Paul K. Crane, Kristen Dams-O’Connor
Publikováno v:
Journal of Alzheimer's Disease. :1-13
Background: Prior studies into the association of head trauma with neuropathology have been limited by incomplete lifetime neurotrauma exposure characterization. Objective: To investigate the neuropathological sequelae of traumatic brain injury (TBI)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30b76f25a8144b063b336f4ade3ee0ae
https://doi.org/10.3233/jad-221224
https://doi.org/10.3233/jad-221224
Autor:
Rebecca L. Kow, Timothy J. Strovas, Pamela J. McMillan, Ashley M. Jacobi, Mark A. Behlke, Aleen D. Saxton, Caitlin S. Latimer, C. Dirk Keene, Brian C. Kraemer
Publikováno v:
Neurobiology of Disease, Vol 147, Iss , Pp 105148- (2021)
Aging drives pathological accumulation of proteins such as tau, causing neurodegenerative dementia disorders like Alzheimer's disease. Previously we showed loss of function mutations in the gene encoding the poly(A) RNA binding protein SUT-2/MSUT2 su
Externí odkaz:
https://doaj.org/article/a306260c5f1f44a8881453e339558866
Autor:
Kurt Farrell, Megan A Iida, Jonathan D Cherry, Alicia Casella, Thor D Stein, Kevin F Bieniek, Jamie M Walker, Timothy E Richardson, Charles L White, Victor E Alvarez, Bertrand R Huber, Dennis W Dickson, Ricardo Insausti, Kristen Dams-O'Connor, Jean-Paul Vonsattel, Andy F Teich, Marla Gearing, Jonathan Glass, Juan C Troncoso, Matthew P Frosch, Bradley T Hyman, Melissa E Murray, Johannes Attems, Margaret E Flanagan, Qinwen Mao, M-Marsel Mesulam, Sandra Weintraub, Randy L Woltjer, Thao Pham, Julia Kofler, Julie A Schneider, Lei Yu, Dushyant P Purohit, Vahram Haroutunian, Patrick R Hof, Sam Gandy, Mary Sano, Thomas G Beach, Wayne Poon, Claudia H Kawas, María M Corrada, Robert A Rissman, Jeff Metcalf, Sara Shuldberg, Bahar Salehi, Peter T Nelson, John Q Trojanowski, Edward B Lee, David A Wolk, Corey T McMillan, C Dirk Keene, Caitlin S Latimer, Thomas J Montine, Gabor G Kovacs, Mirjam I Lutz, Peter Fischer, Richard J Perrin, Nigel J Cairns, Ann C McKee, John F Crary
Publikováno v:
Journal of neuropathology and experimental neurology. 81(10)
Chronic traumatic encephalopathy (CTE) is a tauopathy associated with repetitive mild head impacts characterized by perivascular hyperphosphorylated tau (p-tau) in neurofibrillary tangles (NFTs) and neurites in the depths of the neocortical sulci. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1916920e77c4850d5f693bd6ae2508d1
https://pubmed.ncbi.nlm.nih.gov/36004533
https://pubmed.ncbi.nlm.nih.gov/36004533
Autor:
Heather Maioli, Rhonda Mittenzwei, Jane B Shofer, Kathryn P Scherpelz, Desiree Marshall, Amber L Nolan, Peter T Nelson, C Dirk Keene, Caitlin S Latimer
Publikováno v:
Journal of Neuropathology & Experimental Neurology.
Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) is a dementia-related proteinopathy common in the elderly population. LATE-NC stages 2 or 3 are consistently associated with cognitive impairment. A condensed proto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43bf7202f8fccc0208e88a79063ac62b
https://doi.org/10.1093/jnen/nlad035
https://doi.org/10.1093/jnen/nlad035