Výsledky vyhledávání

Akademický článek

HDAC6 selective inhibition of melanoma patient T-cells augments anti-tumor characteristics

Autor: Andressa S. Laino, B. C. Betts, A. Veerapathran, I. Dolgalev, A. Sarnaik, S. N. Quayle, S. S. Jones, J. S. Weber, David M. Woods

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-16 (2019)

Abstract Background Therapies targeting anti-tumor T-cell responses have proven successful in the treatment of a variety of malignancies. However, as most patients still fail to respond, approaches to augment immunotherapeutic efficacy are needed. He

Externí odkaz: https://doaj.org/article/4da9890e824b43518f3c93b6436cf8e7

Zobrazit plný text záznamu

Clinical and immune correlate results from a phase 1b study of the histone deacetylase inhibitor mocetinostat with ipilimumab and nivolumab in unresectable stage III/IV melanoma

Autor: Jeffrey S. Weber, Benjamin A. Levinson, Andressa S. Laino, Anna C. Pavlick, David M. Woods

Publikováno v: Melanoma research. 32(5)

Checkpoint immunotherapies (CPIs) have improved outcomes for metastatic melanoma patients, with objective response rates to combination ipilimumab and nivolumab of ~58%. Preclinical data suggest that histone deacetylase (HDAC) inhibition enhances ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0e4deae7f2f0ab67051c77dc0003225
https://pubmed.ncbi.nlm.nih.gov/35678233

Zobrazit plný text záznamu

Akademický článek

C reactive protein impairs adaptive immunity in immune cells of patients with melanoma

Autor: Jeffrey Weber, Michelle Krogsgaard, Tatsuya Yoshida, Junya Ichikawa, Iulia Giuroiu, Andressa S Laino, Yuhan Hao, Melinda Vassallo, David M Woods, F Stephen Hodi

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)

Background High C reactive protein (CRP) levels have been reported to be associated with a poor clinical outcome in a number of malignancies and with programmed cell death protein 1 immune checkpoint blockade in patients with advanced cancer. Little

Externí odkaz: https://doaj.org/article/aae5fb414af742819dd542c979601775

Zobrazit plný text záznamu

Akademický článek

Serum interleukin-6 and C-reactive protein are associated with survival in melanoma patients receiving immune checkpoint inhibition

Autor: Jeffrey Weber, David Woods, Andressa S Laino, Melinda Vassallo, Xiaozhong Qian, Hao Tang, Megan Wind-Rotolo

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)

Background Inflammatory mediators, including acute phase reactants and cytokines, have been reported to be associated with clinical efficacy in patients with melanoma and other cancers receiving immune checkpoint inhibitors (ICI). Analyses of patient

Externí odkaz: https://doaj.org/article/7cfe45910c204b928110a2582097e79b

Zobrazit plný text záznamu

Data from Decreased Suppression and Increased Phosphorylated STAT3 in Regulatory T Cells are Associated with Benefit from Adjuvant PD-1 Blockade in Resected Metastatic Melanoma

Autor: Jeffrey S. Weber, Brian C. Betts, Kelly Walton, Anders Berglund, Andressa S. Laino, Rupal Ramakrishnan, David M. Woods

Purpose:PD-1 blockade induces durable responses in patients with metastatic melanoma and prolongs relapse-free survival in patients with resected melanoma; however, current biomarkers do not consistently associate with patient responses. In this stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::831c99401ee25cb67283418bd15bdbb8
https://doi.org/10.1158/1078-0432.c.6527172.v1

Zobrazit plný text záznamu

Data from Rapid Expansion of Highly Functional Antigen-Specific T Cells from Patients with Melanoma by Nanoscale Artificial Antigen-Presenting Cells

Autor: Jeffrey S. Weber, Jonathan P. Schneck, Kristi Jones, Mathias Oelke, Sojung Kim, David Woods, Melinda Vassallo, Andressa S. Laino, Ariel Isser, Tatsuya Yoshida, Junya Ichikawa

Purpose:Generation of antigen-specific T cells from patients with cancer employs large numbers of peripheral blood cells and/or tumor-infiltrating cells to generate antigen-presenting and effector cells commonly requiring multiple rounds of restimula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::225159bde52db6701a2d2eaa3f9d559c
https://doi.org/10.1158/1078-0432.c.6529425.v1

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání