Zobrazeno 1 - 10
of 16
pro vyhledávání: '"S. L. Steelman"'
Publikováno v:
British Journal of Clinical Pharmacology. 4:31S-36S
1 In the fasting state, peak plasma levels of diflunisal were achieved within 2 hours. The drug was not metabolized and almost totally excreted in the urine as unchanged or conjugated drug. The terminal plasma half-life was approximately 8 hours. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffde3dad53291d60d384e02cba85e92d
https://doi.org/10.1111/j.1365-2125.1977.tb04511.x
https://doi.org/10.1111/j.1365-2125.1977.tb04511.x
Autor:
T. B. Tjandramaga, P. J. Deschepper, C. Daurio, M. De Roo, Kenneth F. Tempero, L. Verhaest, S. L. Steelman
Publikováno v:
Clinical Pharmacology & Therapeutics. 23:669-676
Fecal blood loss was evaluated in normal subjects with 51Cr-labeled red cells. In a double-blind parallel study in 10 subjects, 250 mg diflunisal twice daily did not significantly increase blood loss in two consecutive treatment periods, while 750 mg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae5d1b214e1212485ddf0ba61bcee108
https://doi.org/10.1002/cpt1978236669
https://doi.org/10.1002/cpt1978236669
Publikováno v:
Journal of International Medical Research. 6:172-179
A single dose experiment was used to evaluate the analgesic effect of diflunisal, a new salicylic acid derivative. Three dose levels of diflunisal (125 mg, 250 mg, and 500 mg) were compared to one dose level of acetylsalicylic acid (ASA) (600 mg) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ad0bbc9b501c568299313036a6d0fb9
https://doi.org/10.1177/030006057800600302
https://doi.org/10.1177/030006057800600302
Publikováno v:
Current medical research and opinion. 5(7)
Faecal blood loss was measured in normal male volunteers using 51Cr-labelled red cells. In a double-blind parallel study in 10 subjects, the effect of 250 mg diflunisal twice daily was compared with 750 mg aspirin 4-times daily. Drugs were taken duri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec19b64515b87d8c88b36a289342f4cd
https://pubmed.ncbi.nlm.nih.gov/699626
https://pubmed.ncbi.nlm.nih.gov/699626
Publikováno v:
Endocrinology. 119(4)
Mouse fibroblast cell lines which secrete bovine (b) GH have been generated. This was accomplished by cotransforming mouse L cells (thymidine kinase-negative [TK-] and adenine phosphoribosyl transferase-negative [APRT-]) with DNA molecules encoding t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a364202788db02fc69456c20d67f1ad9
https://pubmed.ncbi.nlm.nih.gov/3757900
https://pubmed.ncbi.nlm.nih.gov/3757900
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 3(6)
5-(2'4'-Difluorophenyl) [carboxy-14C]salicyclic acid (MK-647) was quickly and completely absorbed in rats, dogs, and man. Peak levels of plasma radioactivity occurred in 1-2 hr after oral administration. The dose was 10 mg/kg in rats and dogs, and 50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b24d516bb65a5a58079f0f3526c87c57
https://pubmed.ncbi.nlm.nih.gov/1220
https://pubmed.ncbi.nlm.nih.gov/1220
Publikováno v:
Advances in experimental medicine and biology. 188
Based upon the clinical finding that a Merck somatostatin-14 (S-14) analog induced steatorrhea in man, we sought to develop animal models to study the effects of S-14 and a series of synthetic analogs on absorption. Rats were trained to eat a diet (p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::684026fee400262918ff4e2157aa9b1a
https://pubmed.ncbi.nlm.nih.gov/2863942
https://pubmed.ncbi.nlm.nih.gov/2863942
Publikováno v:
Current medical research and opinion. 5(7)
SummaryStudies are reviewed on diflunisal, a new analgesic agent with an improved therapeutic index, compared with acetylsalicylic acid, in animals and humans. Pharmacokinetic data indicate that a twice-daily dosage regimen of diflunisal is adequate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c3b04af88559ce64efa47cc5621bc15
https://pubmed.ncbi.nlm.nih.gov/359244
https://pubmed.ncbi.nlm.nih.gov/359244
Autor:
B M, DOBYNS, S L, STEELMAN
Publikováno v:
Endocrinology. 52(6)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::37f75c5078a4963f2f34874a50d3eba8
https://pubmed.ncbi.nlm.nih.gov/13060282
https://pubmed.ncbi.nlm.nih.gov/13060282