Výsledky vyhledávání - "S. L. Schreiber"

Crystallization and preliminary X-ray analysis of twinned crystals of a chimeric FK506 binding protein 12 and 13 complexed with FK506

Autor: S. L. Schreiber, J. Clardy, C. Nielsen, Jun Liang, S. Ealick

Publikováno v: Acta Crystallographica Section D Biological Crystallography. 52:207-210

An FKBPI2/13 chimera with the 80s loop of FKBPI3 replacing the corresponding loop in FKBPI2 tightly binds the immunosuppressive agents FK506 and rapamycin and efficiently catalyzes peptidyl-prolyl cis-trans isomerization. However, the chimera's compl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff801cc3b93d050ce0471e42f9a31f65
https://doi.org/10.1107/s090744499500641x

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Structure-Function Analysis of SH3 Domains: SH3 Binding Specificity Altered by Single Amino Acid Substitutions

Autor: S. Richard, S. L. Schreiber, Richard J. Rickles, A. S. Shaw, Joan S. Brugge, Zhigang Weng, Sibo Feng

Publikováno v: Molecular and Cellular Biology. 15:5627-5634

SH3 domains mediate intracellular protein-protein interactions through the recognition of proline-rich sequence motifs on cellular proteins. Structural analysis of the Src SH3 domain (Src SH3) complexed with proline-rich peptide ligands revealed thre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f7c7a247de2eda253885bb5d2b1a3a
https://doi.org/10.1128/mcb.15.10.5627

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FKBP54, a novel FK506-binding protein in avian progesterone receptor complexes and HeLa extracts

Autor: M R Deibel, S L Schreiber, Mark W. Albers, David F. Smith, K L Leach

Publikováno v: Journal of Biological Chemistry. 268:24270-24273

Avian progesterone receptor complexes contain five major co-purifying proteins, including hsp90, hsp70, and a 23-kDa protein. The other receptor-associated proteins, p50 and p54, share amino acid sequence similarities with a 52-59-kDa component (p59,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc9d06de35c45fc2f9e8b573dcb930ba
https://doi.org/10.1016/s0021-9258(20)80520-1

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ChemInform Abstract: Total Synthesis of FK 506 and an FKBP Probe Reagent, (C8,C9-13C2)-FK 506. Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

Autor: S. L. Schreiber, M. Nakatsuka

Publikováno v: ChemInform. 23

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::54587b42df54d3cb065d7fbf43f94e96
https://doi.org/10.1002/chin.199201343

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ChemInform Abstract: Total Synthesis of the FK506/FKBP Complex

Autor: S. L. SCHREIBER, J. A. RAGAN, R. F. STANDAERT

Publikováno v: ChemInform. 23

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1a7095a9b6a61f31d33baec9fa435f17
https://doi.org/10.1002/chin.199230272

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ChemInform Abstract: Synthesis, Structure, and Mechanism in Immunophilin Research

Autor: D. D. Johnson, L. W. Schultz, S. D. Meyer, S. L. Schreiber, D. G. Alberg, M. Andrus, D. Romo, P. J. Belshaw, Y. Ikeda, Jon Clardy

Publikováno v: ChemInform. 26

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9351dfe03144b049d3614299eaa6f910
https://doi.org/10.1002/chin.199502302

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INBIBITION OF LIVER, KIDNEY, AND INTESTINE REGENERATION BY RAPAMYCIN

Autor: Q. H. Zeng, Alessandro Azzarone, C. Scotti, S. L. Schreiber, A. Francavilla, Giuseppe Carrieri, Thomas E. Starzl, Kendrick A. Porter

Publikováno v: Transplantation. 53:496-498

For a decade, liver transplant recipients have been treated with cyclosporine, a drug with modest hepatotoxicity (1). Concern that CsA might inhibit hepatic regeneration or the ability of the transplanted liver to adjust its size to that of the recip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a6c3143f885541c1d76e1051b760626b
https://doi.org/10.1097/00007890-199202010-00045

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Selection of gp41-mediated HIV-1 cell entry inhibitors from biased combinatorial libraries of non-natural binding elements

Autor: M, Ferrer, T M, Kapoor, T, Strassmaier, W, Weissenhorn, J J, Skehel, D, Oprian, S L, Schreiber, D C, Wiley, S C, Harrison

Publikováno v: Nature structural biology. 6(10)

The trimeric, alpha-helical coiled-coil core of the HIV-1 gp41 ectodomain is thought to be part of a transient, receptor-triggered intermediate in the refolding of the envelope glycoprotein into a fusion-active conformation. In an effort to discover

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8b7d5112f5fe3396b54dcbdb2392fe1e
https://pubmed.ncbi.nlm.nih.gov/10542088

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Immunophilins, ligands, and the control of signal transduction

Autor: S L, Schreiber, G R, Crabtree

Publikováno v: Harvey lectures. 91

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8c752870a3958079d8b30b726aea3cf6
https://pubmed.ncbi.nlm.nih.gov/9127988

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GTP-dependent binding of the antiproliferative agent didemnin to elongation factor 1 alpha

Autor: C M, Crews, J L, Collins, W S, Lane, M L, Snapper, S L, Schreiber

Publikováno v: The Journal of biological chemistry. 269(22)

The marine natural product, didemnin B, is a 7-amino acid, cyclic depsipeptide that inhibits G1 cell cycle progression at nanomolar concentrations by undefined mechanisms. It has been reported to exhibit immunosuppressive activities in animals and is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0cdcc749169d4699d6665a42ae729a04
https://pubmed.ncbi.nlm.nih.gov/8195179

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