Zobrazeno 1 - 10
of 28
pro vyhledávání: '"S. L. Rajasekhar Karna"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract In burn patients Pseudomonas aeruginosa infection is a major cause of morbidity. Analysis of the pathogen’s gene expression as it transitions from colonization to acute and then biofilm wound infection may provide strategies for infection
Externí odkaz:
https://doaj.org/article/bd9bacd5ee0a44979f86caca00354048
Publikováno v:
Burns. 47:1818-1832
Burn wound infection often involves a diverse combination of bacterial and fungal pathogens. In this study, we characterize the mixed species burn wound infection by inoculating the burn surface with 1 × 103/4/5 CFU of Pseudomonas aeruginosa, Staphy
Autor:
Jesse Q Nguyen, Fatemeh Sanjar, S L Rajasekhar Karna, Andrea B Fourcaudot, Li-Ju Wang, David T Silliman, Zhao Lai, Yidong Chen, Kai P Leung
Publikováno v:
J Burn Care Res
Hypertrophic scars are a common negative outcome of deep partial-thickness (DPT) burn wounds resulting in increased dermal thickness, wound area contracture, and inflammation of the affected area. The red Duroc and Yorkshire porcine breeds are common
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e95793f98e8441f7b68b2b833d9ad98
https://europepmc.org/articles/PMC9629425/
https://europepmc.org/articles/PMC9629425/
Autor:
S L Rajasekhar Karna, Peter D'Arpa, Tsute Chen, Li-Wu Qian, Andrea B Fourcaudot, Kazuyoshi Yamane, Ping Chen, Johnathan J Abercrombie, Tao You, Kai P Leung
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0165312 (2016)
Pseudomonas aeruginosa infections of wounds in clinical settings are major complications whose outcomes are influenced by host responses that are not completely understood. Herein we evaluated transcriptomic changes of wounds as they counter P. aerug
Externí odkaz:
https://doaj.org/article/670608c0be564e10976134302982b8a9
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports
Scientific Reports
In burn patients Pseudomonas aeruginosa infection is a major cause of morbidity. Analysis of the pathogen’s gene expression as it transitions from colonization to acute and then biofilm wound infection may provide strategies for infection control.
Autor:
Kenneth S Brandenburg, Kai P. Leung, S. L. Rajasekhar Karna, Christopher Olverson, Alan J Weaver
Publikováno v:
European Burn Journal
Volume 2
Issue 3
Pages 9-124
Volume 2
Issue 3
Pages 9-124
Every year, thousands of soldiers and civilians succumb to burn wound trauma with highly unfavorable outcomes. We previously established a modified Walker-Mason rat scald model exhibiting a P. aeruginosa infection. Here we characterize deep partial-
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports
Scientific Reports
Excessive inflammation or its absence may result in impaired wound healing. Neutrophils are among the first innate immune cells to arrive at the injury site. They participate in infection control and debris removal to initiate healing. If not timely
Autor:
Tricia A Van Laar, Ying-Han Lin, Christine L Miller, S L Rajasekhar Karna, James P Chambers, J Seshu
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e38171 (2012)
Borrelia burgdorferi, the agent of Lyme disease, is a spirochetal pathogen with limited metabolic capabilities that survives under highly disparate host-specific conditions. However, the borrelial genome encodes several proteins of the mevalonate pat
Externí odkaz:
https://doaj.org/article/8cf0ea0655554cc393387d83d2028759
Autor:
Li-Wu Qian, Ping Chen, Shankar J. Evani, Johnathan J. Abercrombie, Andrea B Fourcaudot, Kai P. Leung, Jesse Q Nguyen, S. L. Rajasekhar Karna, Eliza A Sebastian
Publikováno v:
Microbial pathogenesis. 147
Pseudomonas aeruginosa (a Gram-negative bacterium) is an opportunistic pathogen found in many infected wounds and is known to impair healing. To test the hypothesis that knocking out P. aeruginosa genes that are overexpressed during wound infection c
Autor:
Janakiram Seshu, Robert L. Reddick, S. L. Rajasekhar Karna, Tricia A. Van Laar, Camaron R. Hole, Christine L. Miller, Floyd L. Wormley
Publikováno v:
Microbes and Infection. 18:430-435
Lyme disease (LD) is a systemic disorder caused by Borrelia burgdorferi. Lyme spirochetes encode for a functional 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGR EC 1.1.1.88) serving as a rate limiting enzyme of the mevalonate pathway that con