Zobrazeno 1 - 10
of 31
pro vyhledávání: '"S. L. Lowe"'
Autor:
Jian-Yun Dong, James S. Norris, S Rubinchik, S. L. Lowe, Christina Voelkel-Johnson, Marc L. Hyer
Publikováno v:
Current Gene Therapy. 1:123-136
Prostate cancer is the second leading cause of cancer death in the United States. Treatment options for confined disease are generally successful in prolonging life but long-term cures (10-15 years) are elusive for the majority of patients. The progn
Autor:
S L Lowe
Publikováno v:
Journal of Medical Ethics. 23:154-163
It is widely accepted now that a patient's right to refuse treatment extends to circumstances in which the exercise of that right may lead to the patient's death. However, it is also often effectively assumed, without argument, that this implies a pa
Publikováno v:
Neuroscience. 38:571-577
There is little information about major constituents of the brain in Alzheimer's disease. In the case of amino acids most of the previous data are contradictory. These have been interpreted in an anatomic and neurotransmitter as well as a metabolic c
Autor:
S Rubinchik, Saeed Elojeimy, Alicja Bielawska, Terrence A. Day, C Landon, John McKillop, Christina Voelkel-Johnson, Marc L. Hyer, James S. Norris, David H. Holman, S. L. Lowe, Jian-Yun Dong, Stephen Tomlinson, Lina M. Obeid, Mahvash Tavassoli, Xiang Liu, Kristi L. Norris, Yusuf A. Hannun, A El-Zawahri
Publikováno v:
Cancer gene therapy. 13(12)
As of January 2005, there were 1020 gene therapy clinical trials ongoing worldwide with 675 or 66.2% devoted to cancer gene therapy. The majority are occurring in the US and Europe (http://www.wiley.co.uk/genetherapy/clinical/). At the present time,
Publikováno v:
Journal of molecular recognition : JMR. 14(1)
Brownian dynamics (BD) was used to simulate the binding of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) to G- and F-actin. High-resolution three-dimensional models (X-ray and homology built) of the proteins were used in the simulations. The elect
Autor:
Jian-Yun Dong, Tsuyoshi Honda, S Rubinchik, James S. Norris, S. L. Lowe, Timothy J. McDonnell
Publikováno v:
Gene therapy. 8(18)
In prostate carcinoma, overexpression of the anti-apoptotic gene Bcl-2 has been found to be associated with resistance to therapies including radiation and androgen ablation. Restoring the balance of Bcl-2 family members may result in the induction o
Publikováno v:
Gene therapy. 8(3)
Tissue-specific transgene expression is a valuable research tool and is of great importance in delivering toxic gene products with adenovirus vectors to tumors. Limiting cytotoxic gene expression to the target cells is highly desirable. While a numbe
Publikováno v:
Genomics. 57(2)
Transport of proteins along the exocytotic pathway is primarily achieved by vesicular intermediates. Two proteins, Golgi SNAREs of 27 kDa, GS27, and of 28 kDa, GS28 (HGMW-approved nomenclature GOSR2 and GOSR1, respectively), are important trafficking
Autor:
Andrea Malizia, Paulo Henrique Ferreira Bertolucci, Paul T. Francis, M. N. Pangalos, J R Bartlett, P K Bridges, David M. Bowen, Andrew W. Procter, S. L. Lowe
Publikováno v:
The British journal of psychiatry : the journal of mental science. 160
Samples of ventricular CSF were taken from 52 consecutive patients admitted for psychosurgery for intractable depression. Concentrations of asparagine, aspartate, glutamine, glutamic acid, and serine were determined. Glutamate and aspartate concentra
Autor:
Andrew W. Procter, David M. Bowen, A.J.L. Barton, S. L. Lowe, A. Najlerahim, R.C.A. Pearson, Paulo Henrique Ferreira Bertolucci, Paul Harrison
Publikováno v:
Brain research. Molecular brain research. 9(1-2)
In situ hybridization histochemistry has been used to study the amount of M1 muscarinic receptor mRNA in temporal cortex from subjects with Alzheimer's disease and other neurodegenerative disorders, where the duration of terminal coma was known. Tota