Zobrazeno 1 - 10 of 206 pro vyhledávání: '"S. L. Harbeson"'
1
Kinase Chemogenomics: Targeting the Human Kinome for Target Validation and Drug Discovery
Autor: S. Pazhanisamy, Paul Taslimi, S. L. Harbeson, Francesco G. Salituro, Guy W. Bemis, E. ter Haar, Albert C. Pierce, W. P. Walters
Publikováno v: Mini-Reviews in Medicinal Chemistry. 4:235-253
Chemogenomics is a gene family-based approach to drug discovery and target validation. This review will summarize the application of this interdisciplinary approach to the protein kinases of the human genome with emphasis upon the synergies and effic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eea33c6cf5bd6a57ec7d3933a7229be
https://doi.org/10.2174/1389557043487367
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2
Akademický článek
Navigating The Deuteration Landscape: Innovations, Challenges, and Clinical Potential of Deuterioindoles.
Autor: Zhang L; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy and College of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China., Zhang S; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy and College of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China., Zhang Y; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy and College of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China., Liu B; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, China., Li X; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy and College of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China., Han B; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy and College of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.
Publikováno v: Chembiochem : a European journal of chemical biology [Chembiochem] 2024 Dec 10, pp. e202400837. Date of Electronic Publication: 2024 Dec 10.
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3
Akademický článek
De Novo Synthesis of α‐Ketoamides via Pd/TBD Synergistic Catalysis.
Autor: Chen, Jia‐He1 (AUTHOR), Zhang, Li‐Ren1 (AUTHOR), Wang, Zhang‐Yang1 (AUTHOR), Liu, Lu‐Jie1 (AUTHOR), Tu, Li‐Ping1 (AUTHOR), Zhang, Yun1,2 (AUTHOR), Chen, Yong‐Zheng1,2 (AUTHOR), Han, Wen‐Yong1,2 (AUTHOR) hanwy@zmu.edu.cn
Publikováno v: Advanced Science. 9/11/2024, Vol. 11 Issue 34, p1-12. 12p.
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4
Conformation of a neurokinin antagonist in solution. 2D NMR and restrained molecular dynamics study
Autor: J A, Malikayil, S L, Harbeson
Publikováno v: International journal of peptide and protein research. 39(6)
The hexapeptide [cyclo(Leu1 psi(CH2NH2)Leu2-Gln3-Trp4-Phe5-Gly6)]+1 is a potent antagonist of neurokinin A activity in tissues of hamster urinary bladder. The solution conformation of this cyclic hexapeptide has been characterized by the combined use
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::69c700beb841ceb9ea4e5bcb16d71e80
https://pubmed.ncbi.nlm.nih.gov/1328098
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6
Airway effects of inhaled bradykinin, substance P, and neurokinin A in sheep
Autor: M. Soler, S. G. Farmer, A. Ahmed, A. Cortes, William M. Abraham, L. E. Baugh, S. L. Harbeson
Publikováno v: The Journal of allergy and clinical immunology. 87(2)
The effects of inhaled bradykinin (BK), substance P (SP), and neurokinin A (NKA) on pulmonary resistance and airway responsiveness to carbachol were studied in conscious allergic sheep. Inhaled BK (20 breaths, 0.1 to 5.0 mg.ml-1) caused dose-dependen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf2eec5c31db959140c43c357edc5d85
https://pubmed.ncbi.nlm.nih.gov/1704388
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7
Akademický článek
Sulfonium Salt Reagents for the Introduction of Deuterated Alkyl Groups in Drug Discovery.
Autor: Ban, Kazuho1 (AUTHOR), Imai, Keisuke1 (AUTHOR), Oyama, Shuki1 (AUTHOR), Tokunaga, Jin1 (AUTHOR), Ikeda, Yui2 (AUTHOR), Uchiyama, Hiromasa2 (AUTHOR), Kadota, Kazunori2 (AUTHOR), Tozuka, Yuichi2 (AUTHOR), Akai, Shuji1 (AUTHOR), Sawama, Yoshinari1,3 (AUTHOR) sawama@phs.osaka-u.ac.jp
Publikováno v: Angewandte Chemie. 11/27/2023, Vol. 135 Issue 48, p1-9. 9p.
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8
Akademický článek
In situ Generated Iridium Nanoparticles as Hydride Donors in Photoredox‐Catalyzed Hydrogen Isotope Exchange Reactions with Deuterium and Tritium Gas.
Autor: Kramp, Henrik1 (AUTHOR), Weck, Remo1 (AUTHOR), Sandvoss, Martin1 (AUTHOR), Sib, Anna1 (AUTHOR), Mencia, Gabriel2 (AUTHOR), Fazzini, Pier‐Francesco2 (AUTHOR), Chaudret, Bruno2 (AUTHOR), Derdau, Volker1 (AUTHOR) Volker.Derdau@sanofi.com
Publikováno v: Angewandte Chemie. 9/4/2023, Vol. 135 Issue 36, p1-6. 6p.
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9
Akademický článek
Hydrogen Isotope Exchange by Homogeneous Iridium Catalysis in Aqueous Buffers with Deuterium or Tritium Gas.
Autor: Stork, Carla Marie1,2 (AUTHOR), Weck, Remo1 (AUTHOR), Valero, Mégane1 (AUTHOR), Kramp, Henrik1 (AUTHOR), Güssregen, Stefan1 (AUTHOR), Waldvogel, Siegfried R.2 (AUTHOR), Sib, Anna1 (AUTHOR), Derdau, Volker1 (AUTHOR) Volker.Derdau@sanofi.com
Publikováno v: Angewandte Chemie. Jun2023, Vol. 135 Issue 24, p1-5. 5p.
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10
Akademický článek
Cobalt‐Catalyzed Asymmetric Deuteration of α‐Amidoacrylates for Stereoselective Synthesis of α,β‐Dideuterated α‐Amino Acids.
Autor: Li, Aibo1 (AUTHOR), Song, Xinjian1 (AUTHOR), Ren, Qiao1 (AUTHOR), Bao, Peiwang1 (AUTHOR), Long, Xinyu1 (AUTHOR), Huang, Fuli1 (AUTHOR), Yuan, Lvjiang1 (AUTHOR), Zhou, Jianrong Steve2 (AUTHOR) jrzhou@pku.edu.cn, Qin, Xurong1,3 (AUTHOR) xurqin@swu.edu.cn
Publikováno v: Angewandte Chemie. 5/8/2023, Vol. 135 Issue 20, p1-8. 8p.
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