Výsledky vyhledávání - "S. L. Demeester"

Nitric oxide inhibits stress-induced endothelial cell apoptosis

Autor: Yuyu Qiu, S. L. Demeester, J. P. Cobb, Timothy G. Buchman, Irene E. Karl, Richard S. Hotchkiss, K. Dunnigan

Publikováno v: Critical Care Medicine. 26:1500-1509

OBJECTIVES To determine a mechanism by which nitric oxide alters induction of stress-induced endothelial cell apoptosis in vitro. Apoptosis is a form of cellular suicide that has been implicated in the pathogenesis of multiple organ dysfunction syndr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::878f4a40aeba2be1d3d047266cb8501d
https://doi.org/10.1097/00003246-199809000-00016

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Stress-induced fractal rearrangement of the endothelial cell cytoskeleton causes apoptosis

Autor: Kevin W. Tinsley, Timothy G. Buchman, Irene E. Karl, Dale F. Osborne, S. L. Demeester, Richard S. Hotchkiss, J. Perren Cobb

Publikováno v: Surgery. 124:362-371

Background: Apoptosis, a mechanism of cell death prominent in critical illnesses including disseminated inflammation and multiorgan dysfunction syndrome, is characterized by morphologic changes including cell shrinkage, condensation of organelles, bl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::450e8cbaac5aedc470b9e54bc6422c00
https://doi.org/10.1016/s0039-6060(98)70142-4

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PYRROLIDINE DITHIOCARBAMATE ACTIVATES THE HEAT SHOCK RESPONSE AND THEREBY INDUCES APOPTOSIS IN PRIMED ENDOTHELIAL CELLS

Autor: J. P. Cobb, S. L. Demeester, K. Dunnigan, Timothy G. Buchman, Irene E. Karl, Richard S. Hotchkiss, Yuyu Qiu

Publikováno v: Shock. 10:1-6

Transcription factor NF-kappaB is an important regulator of the cellular response to diverse stresses. Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB activity, was used to determine the role of this transcription factor in our model of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36f30f040080035911b0f61301eb2801
https://doi.org/10.1097/00024382-199807000-00001

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Endothelial cell apoptosis is accelerated by inorganic iron and heat via an oxygen radical dependent mechanism

Autor: Ammini K. Jacob, Paul E. Swanson, Masako Hiramatsu, S. L. Demeester, J. Perren Cobb, Timothy G. Buchman, Irene E. Karl, Richard S. Hotchkiss

Publikováno v: Surgery. 122:243-254

Background. Iron participates in diverse pathologic processes by way of the Fenton reaction, which catalyzes the formation of reactive oxygen species (ROS). To test the hypothesis that this reaction accelerates apoptosis, we used human umbilical vein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3965592e4e8e38e391ef5a285cd3a017
https://doi.org/10.1016/s0039-6060(97)90015-5

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Stress-induced fractal rearrangement of the endothelial cell cytoskeleton causes apoptosis

Autor: S L, DeMeester, J P, Cobb, R S, Hotchkiss, D F, Osborne, I E, Karl, K W, Tinsley, T G, Buchman

Publikováno v: Surgery. 124(2)

Apoptosis, a mechanism of cell death prominent in critical illnesses including disseminated inflammation and multiorgan dysfunction syndrome, is characterized by morphologic changes including cell shrinkage, condensation of organelles, blebbing, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a51704c8ea76c14abd17581a8fe931bf
https://pubmed.ncbi.nlm.nih.gov/9706160

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Heat Shock Induces IκB-α and Prevents Stress-Induced Endothelial Cell Apoptosis

Autor: S. L. Demeester, Ammini K. Jacob, J. Perren Cobb, Keith Dunnigan, Richard S. Hotchkiss, Yuyu Qiu, Timothy G. Buchman, Irene E. Karl

Publikováno v: Archives of Surgery. 132:1283

Objective: To determine whether prior heat shock would attenuate endothelial cell apoptosis and whether any effect of preemptive heat shock is mediated through a nuclear factor kappa B and inhibitor kappa B α mechanism. Design: A randomized, control

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7d034212dd8114f2447223285f8c0d6
https://doi.org/10.1001/archsurg.1997.01430360029005

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