Creating a kidney organoid-vasculature interaction model using a novel organ-on-chip system

Autor: Amanda Bas-Cristóbal Menéndez, Z. Du, T. P. P. van den Bosch, A. Othman, N. Gaio, C. Silvestri, W. Quirós, H. Lin, S. Korevaar, A. Merino, J. Mulder, M. J. Hoogduijn

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)

Abstract Kidney organoids derived from human induced pluripotent stem cells (iPSCs) have proven to be a valuable tool to study kidney development and disease. However, the lack of vascularization of these organoids often leads to insufficient oxygen

Externí odkaz: https://doaj.org/article/e76be4e67e494d13ab3d1089bfb42b3f

Mesenchymal Stromal Cell Derived Membrane Particles Are Internalized by Macrophages and Endothelial Cells Through Receptor-Mediated Endocytosis and Phagocytosis

Autor: Fabiany da Costa Gonçalves, Sander S. Korevaar, Maitane Ortiz Virumbrales, Carla C. Baan, Marlies E. J. Reinders, Ana Merino, Eleuterio Lombardo, Martin J. Hoogduijn

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Mesenchymal stromal cells (MSC) are a promising therapy for inflammatory diseases. However, MSC are large and become trapped in the lungs after intravenous infusion, where they have a short survival time. To steer MSC immunoregulatory therapy beyond

Externí odkaz: https://doaj.org/article/d3a52806923b47a19ac2f960e547d895

Cytokine treatment optimises the immunotherapeutic effects of umbilical cord-derived MSC for treatment of inflammatory liver disease

Autor: Samantha F. H. de Witte, Ana M. Merino, Marcella Franquesa, Tanja Strini, Johanna A. A. van Zoggel, Sander S. Korevaar, Franka Luk, Madhu Gargesha, Lisa O’Flynn, Debashish Roy, Steve J. Elliman, Philip N. Newsome, Carla C. Baan, Martin J. Hoogduijn

Publikováno v: Stem Cell Research & Therapy, Vol 8, Iss 1, Pp 1-12 (2017)

Abstract Background Mesenchymal stromal cells (MSC) possess immunomodulatory properties and low immunogenicity, both crucial properties for their development into an effective cellular immunotherapy. They have shown benefit in clinical trials targeti

Externí odkaz: https://doaj.org/article/f6f80968f8ee4d479319109521a6dbe4

Vitamin D metabolism in human kidney organoids

Autor: Marian C. Clahsen-van Groningen, Carla C. Baan, Thierry P P van den Bosch, Hui Lin, Joost Gribnau, Anusha S. Shankar, Sander S. Korevaar, Hector Tejeda Mora, Sjoerd A A van den Berg, Martin J. Hoogduijn, Ewout J. Hoorn, Ronald van der Wal, Zhaoyu Du

Publikováno v: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association-European Renal Association, 37(1), 190-193. Oxford University Press

Human kidney organoids possess early glomerular and tubular function. However, little is known about their hormone producing ability. In this report, we show that kidney organoids take up and metabolize inactive 25(OH) vitamin D (25(OH)D3). Uptake of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7249774a4fda51fbca3967843eed8af5
https://pure.eur.nl/en/publications/2f5a94c5-2f7a-476a-8c5d-83fcba8224e4

Inflammatory Conditions Dictate the Effect of Mesenchymal Stem or Stromal Cells on B Cell Function

Autor: Franka Luk, Laura Carreras-Planella, Sander S. Korevaar, Samantha F. H. de Witte, Francesc E. Borràs, Michiel G. H. Betjes, Carla C. Baan, Martin J. Hoogduijn, Marcella Franquesa

Publikováno v: Frontiers in Immunology, Vol 8 (2017)

The immunomodulatory capacity of mesenchymal stem or stromal cells (MSC) makes them a promising tool for treatment of immune disease and organ transplantation. The effects of MSC on B cells are characterized by an abrogation of plasmablast formation

Externí odkaz: https://doaj.org/article/7d606eba61fa434b93c68d4278121de9