Zobrazeno 1 - 10
of 739
pro vyhledávání: '"S. Kirkpatrick"'
Publikováno v:
Heritage Science, Vol 12, Iss 1, Pp 1-15 (2024)
Abstract The recent multi-analytical study carried out on the Van Eyck’s Ghent Altarpiece showed the simultaneous presence of several kinds of metal carboxylates in oil-rich glaze layers. This outcome raised the question whether these carboxylates
Externí odkaz:
https://doaj.org/article/06d4a4ae520a4dd2ab69c7ffa220be6d
Publikováno v:
Obesity Science & Practice, Vol 5, Iss 5, Pp 468-478 (2019)
Summary Objective This retrospective study aimed to evaluate the impact of anti‐obesity medication (AOM) initiation, usage and duration on weight loss in a 72‐week precision obesity programme. The type of AOM, diet and exercise plan was chosen ba
Externí odkaz:
https://doaj.org/article/6c065d8d94f446e886fa644c61e32edb
Publikováno v:
AIP Advances, Vol 7, Iss 7, Pp 075014-075014-9 (2017)
Gas cluster ion beams are proposed as a new tool for producing nanometer sized holes in ultrathin 2D films. Surfaces of films of graphene, graphene oxide, MoS2, and HOPG, and also silicon as a reference, were irradiated by Ar gas cluster ion beams (E
Externí odkaz:
https://doaj.org/article/d0abc92babab4551b1570db912f7a0e5
Autor:
Christopher W. Davies, Simon E. Vidal, Lilian Phu, Jawahar Sudhamsu, Trent B. Hinkle, Scott Chan Rosenberg, Frances-Rose Schumacher, Yi Jimmy Zeng, Carsten Schwerdtfeger, Andrew S. Peterson, Jennie R. Lill, Christopher M. Rose, Andrey S. Shaw, Ingrid E. Wertz, Donald S. Kirkpatrick, James T. Koerber
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
UBE2W catalyzes the ubiquitination of protein N-termini but its substrate spectrum is largely unknown. Here, the authors discover mAbs selective for peptides derived from N-terminally ubiquitinated proteins, solve the structure of a peptide-bound mAb
Externí odkaz:
https://doaj.org/article/cbfb2674260f4b51a1c495c83e07dcb5
Autor:
Kimberly Stark, Tatiana Goncharov, Eugene Varfolomeev, Luke Xie, Hai Ngu, Ivan Peng, Keith R. Anderson, Erik Verschueren, Meena Choi, Donald S. Kirkpatrick, Amy Easton, Joshua D. Webster, Brent S. McKenzie, Domagoj Vucic, Baris Bingol
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-15 (2021)
Abstract RIP1 kinase-mediated inflammatory and cell death pathways have been implicated in the pathology of acute and chronic disorders of the nervous system. Here, we describe a novel animal model of RIP1 kinase deficiency, generated by knock-in of
Externí odkaz:
https://doaj.org/article/c403fe72c3fe41429f8c35b23860a00f
Publikováno v:
Journal of Medical Case Reports, Vol 15, Iss 1, Pp 1-5 (2021)
Abstract Background To report the occurrence of tophaceous gout in the cervical spine and to review the literature on spinal gout. Case presentation This report details the occurrence of a large and clinically significant finding of tophaceous gout i
Externí odkaz:
https://doaj.org/article/16013739626741ad8f84cb600ab97758
Autor:
Kelvin F. Cho, Taylur P. Ma, Christopher M. Rose, Donald S. Kirkpatrick, Kebing Yu, Robert A. Blake
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Quantitative profiling of small molecule-protein binding in cells can aid basic biochemical research and drug discovery. Here, the authors develop the Heat Shock Protein Inhibition Protein Stability Assay (HIPStA) as a high-throughput method to asses
Externí odkaz:
https://doaj.org/article/d8e4230757ef4fa5aa0391581b106a4b
Autor:
Avinashnarayan Venkatanarayan, Jason Liang, Ivana Yen, Frances Shanahan, Benjamin Haley, Lilian Phu, Erik Verschueren, Trent B. Hinkle, David Kan, Ehud Segal, Jason E. Long, Tony Lima, Nicholas P.D. Liau, Jawahar Sudhamsu, Jason Li, Christiaan Klijn, Robert Piskol, Melissa R. Junttila, Andrey S. Shaw, Mark Merchant, Matthew T. Chang, Donald S. Kirkpatrick, Shiva Malek
Publikováno v:
Cell Reports, Vol 38, Iss 6, Pp 110351- (2022)
Summary: KRAS, which is mutated in ∼30% of all cancers, activates the RAF-MEK-ERK signaling cascade. CRAF is required for growth of KRAS mutant lung tumors, but the requirement for CRAF kinase activity is unknown. Here, we show that subsets of KRAS
Externí odkaz:
https://doaj.org/article/fa5d3d0fa6ab4799a1b8b428959ad8e4
Autor:
Timurs Maculins, Erik Verschueren, Trent Hinkle, Meena Choi, Patrick Chang, Cecile Chalouni, Shilpa Rao, Youngsu Kwon, Junghyun Lim, Anand Kumar Katakam, Ryan C Kunz, Brian K Erickson, Ting Huang, Tsung-Heng Tsai, Olga Vitek, Mike Reichelt, Yasin Senbabaoglu, Brent Mckenzie, John R Rohde, Ivan Dikic, Donald S Kirkpatrick, Aditya Murthy
Publikováno v:
eLife, Vol 10 (2021)
Defective autophagy is strongly associated with chronic inflammation. Loss-of-function of the core autophagy gene Atg16l1 increases risk for Crohn’s disease in part by enhancing innate immunity through myeloid cells such as macrophages. However, au
Externí odkaz:
https://doaj.org/article/f7e6c7d1cf284be89aa3c3ebd2cb98db
Autor:
Arundhati Sengupta-Ghosh, Sara L. Dominguez, Luke Xie, Kai H. Barck, Zhiyu Jiang, Timothy Earr, Jose Imperio, Lilian Phu, Hanna G. Budayeva, Donald S. Kirkpatrick, Hao Cai, Jeffrey Eastham-Anderson, Hai Ngu, Oded Foreman, Maj Hedehus, Michael Reichelt, Isidro Hotzel, Yonglei Shang, Richard A.D. Carano, Gai Ayalon, Amy Easton
Publikováno v:
Neurobiology of Disease, Vol 124, Iss , Pp 340-352 (2019)
Amyotrophic lateral sclerosis (ALS), a neurodegenerative disease affecting motor neurons, is characterized by rapid decline of motor function and ultimately respiratory failure. As motor neuron death occurs late in the disease, therapeutics that prev
Externí odkaz:
https://doaj.org/article/cd3e464eb6fd4c10b7ea4c66731e7e28