Výsledky vyhledávání - "S. Karl Gotzkowsky"

Treatment satisfaction is associated with improved quality of life in patients treated with inhaled treprostinil for pulmonary arterial hypertension

Autor: Erika B. Rosenzweig, S. Karl Gotzkowsky, Hubert Chen, Carl Arneson, Robert C. Bourge, Andrew Nelsen

Publikováno v: Health and Quality of Life Outcomes

Background Patient treatment satisfaction is likely to be a highly relevant outcome measure in pulmonary arterial hypertension (PAH), a condition for which the benefits of treatment must be weighed against frequent, undesirable side effects, inconven

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e7fe6cfa550ee73500ace33511664b

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Lack of a pharmacokinetic interaction between oral treprostinil and bosentan in healthy adult volunteers

Autor: Kevin Laliberte, S. Karl Gotzkowsky, David Mottola, Allen A. Lai, Jasper Dingemanse

Publikováno v: Journal of clinical pharmacology. 50(7)

Treprostinil diethanolamine is an oral prostacyclin analog currently being evaluated for the treatment of pulmonary arterial hypertension (PAH). Treprostinil is metabolized primarily by cytochrome P450 (CYP) 2C8 with minor contribution from CYP2C9. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::408de2de86d330c9406bbb6cda131209
https://pubmed.ncbi.nlm.nih.gov/20133511

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Poor correlation between 6β-hydroxycortisol:cortisol molar ratios and midazolam clearance as measure of hepatic CYP3A activity

Autor: Ya Chi Chen, Joseph S. Bertino, S. Karl Gotzkowsky, Robert W. Kulawy, Mario L. Rocci, Angela D. M. Kashuba, Anne N. Nafziger

Aims A non-invasive proposed method for measuring CYP3A activity is the urinary 6β-hydroxycortisol:cortisol ratio. This ratio has been used as an indicator of CYP3A induction and inhibition, with mixed results. This investigation evaluated the relat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::890a1635d00cec5e3f9b6c1a1290d229

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Pharmacokinetic and pharmacodynamic investigation of efavirenz in the semen and blood of human immunodeficiency virus type 1-infected men

Autor: Leslie Petch, S. Karl Gotzkowsky, Myron S. Cohen, Susan A. Fiscus, Y. Sunila Reddy, William D. Fiske, Julie Y. Kim, Joseph J. Eron, Angela D. M. Kashuba

Publikováno v: The Journal of infectious diseases. 186(9)

Therapeutic concentrations of antiretroviral agents in seminal plasma (SP) may reduce virus burden and influence sexual transmission of human immunodeficiency virus (HIV) type 1. This study compared the pharmacokinetic, pharmacodynamic, and dose resp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c78cf10aeebd1569e65b3aa0e04c8b
https://pubmed.ncbi.nlm.nih.gov/12402205

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Poor correlation between 24 hr urinary 6β-hydroxy cortisol: Cortisol molar ratios (CMR) and plasma midazolam clearance (MDZ CL) as measures of hepatic CYP3A activity

Autor: S. Karl Gotzkowsky, R.W. Kulaway, William J. Hall, Angela D. M. Kashuba, Anne N. Nafziger, Debra J. Beck, M.L. Rocci, Joseph S. Bertino

Publikováno v: Clinical Pharmacology & Therapeutics. 65:167-167

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eed3bd40d9f022b9c126b940060c5002
https://doi.org/10.1016/s0009-9236(99)80198-2

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