Zobrazeno 1 - 10
of 12
pro vyhledávání: '"S. K. Van Why"'
Publikováno v:
Journal of Clinical Investigation. 92:2850-2857
Parathyroid hormone-related protein (PTHrP) is widely expressed in normal adult and fetal tissues, where it acts in an autocrine/paracrine fashion, stimulates growth and differentiation, and shares early response gene characteristics. Since recovery
Publikováno v:
American Journal of Physiology-Cell Physiology. 265:C712-C719
Ischemia and reperfusion damage mitochondrial structure and impair respiratory function. In this study, 45 min of renal ischemia followed by varying periods of reflow profoundly depressed the activity of several respiratory complexes in mitochondria
Autor:
G. Thullin, Michael Riordan, Rajasree Sreedharan, Michael Kashgarian, Norman J. Siegel, S. K. Van Why
Endogenous heat shock proteins (HSPs) 70 and 25/27 are induced in renal cells by injury from energy depletion. Transfected over-expression of HSPs 70 or 27 (human analogue of HSP25), provide protection against renal cell injury from ATP deprivation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::921e2b4b3c1a5627140da670897c0f82
https://europepmc.org/articles/PMC3014454/
https://europepmc.org/articles/PMC3014454/
Autor:
T. Ardito, S. K. Van Why, Michael Kashgarian, A. S. Mann, Friedhelm Hildebrandt, Norman J. Siegel
Publikováno v:
American Journal of Physiology-Renal Physiology. 263:F769-F775
To determine whether heat shock proteins (HSPs) might be active in cellular recovery following transient ischemia, we examined rat kidneys for 70-kDa HSP (HSP-70) mRNA expression, protein elaboration, and intracellular localization after 45 min of re
Publikováno v:
Pediatric nephrology (Berlin, Germany). 16(2)
We investigated chronic renal failure (CRF) in 166 Iranian children (95 boys and 71 girls) from July 1991 to June 1999. The mean age at onset of CRF was 7.9+/-4.5 years. The most common cause of CRF was congenital urological malformations (78 cases).
Publikováno v:
Current opinion in pediatrics. 10(2)
Publikováno v:
Pediatric nephrology (Berlin, Germany). 11(6)
Hypertension as a complication of Henoch-Schonlein purpura (HSP) is almost uniformly accompanied by evidence of renal involvement, either decreased renal function or urinary abnormalities. We report a 4.5-year-old male with HSP who developed severe h
Activation of heat-shock transcription factor by graded reductions in renal ATP, in vivo, in the rat
Autor:
Norman J. Siegel, Michael Kashgarian, S. K. Van Why, Gunilla Thulin, Xiao Hong Zhu, A. S. Mann
Publikováno v:
The Journal of clinical investigation. 94(4)
Renal ischemia results in both a profound fall in cellular ATP and a rapid induction of the 70 kD heat-shock protein family, HSP-70. The present studies examined the relationship between cellular ATP and induction of the stress response in renal cort
Publikováno v:
Pediatric research. 36(2)
Publikováno v:
The American journal of physiology. 267(1 Pt 2)
Renal ischemia causes redistribution of Na(+)-K(+)-adenosinetriphosphatase (Na(+)-K(+)-ATPase) to the apical membrane of proximal tubules. We determined the time course of regeneration of Na(+)-K(+)-ATPase polarity and sought evidence of increased en