Zobrazeno 1 - 4
of 4
pro vyhledávání: '"S. K. Kuwahara"'
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 25(9)
1. An osmotic mini-pump was used to maintain a constant infusion of radiolabelled [N-dimethyl-14C] aminopyrine into a rat. After implanting the mini-pump, 14CO2 expiration rate was constant within 12 h, and this rate was maintained for 192 h. 2. Trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3920668ecda051f6d67c0220b2fa7517
https://pubmed.ncbi.nlm.nih.gov/8553690
https://pubmed.ncbi.nlm.nih.gov/8553690
In vitro studies of zidovudine (ZDV) phosphorylation may not accurately reflect the in vivo dose-response relationship, which is crucial to determining the relationship between ZDV exposure, efficacy, and toxicity. However, measurement of ZDV phospho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a72c2f9e32444444923b1454f32a4b30
https://europepmc.org/articles/PMC284356/
https://europepmc.org/articles/PMC284356/
Autor:
A, Rakhit, S K, Kuwahara, D R, Jones, V F, Soliman, A N, Kotake, T D, Oglesby, J W, Wasley, S L, Tripp, F L, Douglas
Publikováno v:
Pharmaceutical research. 7(10)
The o-naphthoquinone derivative, CGS 8515 (I), is a potent inhibitor (IC50, 0.1 microM) of 5-lipoxygenase, but its therapeutic potential is compromised by a short plasma half-life (22 min) and extremely poor oral bioavailability (less than 2%). Poor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::edfdcc0a921b34fc064603372d62f985
https://pubmed.ncbi.nlm.nih.gov/2281039
https://pubmed.ncbi.nlm.nih.gov/2281039
Publikováno v:
Xenobiotica. 19:1247-1254
1. Rats and mice have a greater capacity than dogs or humans to N-demethylate the quaternary ammonium compound, N-methylnaltrexone. 2. In dogs, following the i.v. administration of N-[14C-methyl]methylnaltrexone, 50% of the radioactivity was excreted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::571864afb134f04fa00f723b09dd2352
https://doi.org/10.3109/00498258909043176
https://doi.org/10.3109/00498258909043176