Mast Cell Cytokines IL-1, IL-33, and IL-36 Mediate Skin Inflammation in Psoriasis: A Novel Therapeutic Approach with the Anti-Inflammatory Cytokines IL-37, IL-38, and IL-1Ra

Autor: Rosa G. Bellomo, C E Gallenga, Pio Conti, Fabrizio Pregliasco, S K Kritas, Dorina Lauritano, Gianpaolo Ronconi, Caraffa A

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 8076, p 8076 (2021)
International Journal of Molecular Sciences

Psoriasis (PS) is a skin disease with autoimmune features mediated by immune cells, which typically presents inflammatory erythematous plaques, and is associated with many comorbidities. PS exhibits excessive keratinocyte proliferation, and a high nu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3410b2da079c1a70b51bbf5f1d14b9e3
https://www.mdpi.com/1422-0067/22/15/8076

Mast Cells Mediate Skin Inflammation in Psoriasis: A Novel Therapeutic Approach with the Anti-inflammatory Cytokines IL-37, IL-38 and IL-1Ra

Autor: Gianpaolo Ronconi, C E Gallenga, Pio Conti, S K Kritas, Rosa Grazia Bellomo, Dorina Lauritano, Alessandro Caraffa, Fabrizio Pregliasco

Psoriasis (PS) is an autoimmune skin disease mediated by immune cells that typically presents inflammatory erythematous plaques, and it is associated with many comorbidities. PS exhibits excessive keratinocyte proliferation, and a high number of immu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce31472478bb97517c6fc2a0d4dd67a

Coronavirus-19 (SARS-CoV-2) induces acute severe lung inflammation via IL-1 causing cytokine storm in COVID-19: a promising inhibitory strategy

Autor: P, Conti, Al, Caraffa, C E, Gallenga, R, Ross, S K, Kritas, I, Frydas, A, Younes, G, Ronconi

Publikováno v: Journal of biological regulators and homeostatic agents. 34(6)

SARS-Cov-2 infection causes local and systemic inflammation mediated by pro-inflammatory cytokines and COX-2 eicosanoid products with metabolic dysfunction and tissue damage that can lead to patient death. These effects are primarily induced by IL-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4b413914db59d433a8d934ac06cb29f6
https://pubmed.ncbi.nlm.nih.gov/33016027

IL-1 induces throboxane-A2 (TxA2) in COVID-19 causing inflammation and micro-thrombi: inhibitory effect of the IL-1 receptor antagonist (IL-1Ra)

Autor: P, Conti, Al, Caraffa, C E, Gallenga, R, Ross, S K, Kritas, I, Frydas, A, Younes, P, Di Emidio, G, Ronconi, E, Toniato

Publikováno v: Journal of biological regulators and homeostatic agents. 34(5)

IL-1 induces a significant number of metabolic and hematological changes. In experimental animals, IL-1 treatments cause hypotension due to rapid reduction of systemic blood pressure, reduced vascular resistance, increased heart rate and leukocyte ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4277ca93e42c2f96e5514b3db686b6f0
https://pubmed.ncbi.nlm.nih.gov/32744052

Advances in Mast Cell Activation by IL-1 and IL-33 in Sjögren’s Syndrome: Promising Inhibitory Effect of IL-37

Autor: C E Gallenga, R. Ross, Pio Conti, Paolo Di Emidio, A. Younes, Gianpaolo Ronconi, I Frydas, S K Kritas, Luisa Stellin, Alesssandro Caraffa

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 4297, p 4297 (2020)

Sjögren’s syndrome (SS) is a chronic autoimmune inflammatory disease that affects primarily older women and is characterized by irreversible damage of the exocrine glands, including tear (xerophthalmia) and salivary glands (xerostomia). Secretory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdfb5dc4c2469e1b46602c0b6a68b380
http://europepmc.org/articles/PMC7352728