Zobrazeno 1 - 10
of 63
pro vyhledávání: '"S. K. A. Law"'
Autor:
Xiaobo Shang, Peter R. Preiser, Boon Chin Heng, Freddy Yin Chiang Boey, S. K. Alex Law, Subbu S. Venkatraman, Yun Xia
Publikováno v:
Biotechnology and Bioprocess Engineering. 16:127-135
Endothelial cell coverage of blood-contacting devices is crucial to their eventual success in the clinic. Two established human cell lines derived from HUVEC (human umbilical vascular endothelial cells), CRL 2922 and CRL 2873, have been widely utiliz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ad5c08441d1f228bde04f2e8a6aaf8e
https://doi.org/10.1007/s12257-010-0141-9
https://doi.org/10.1007/s12257-010-0141-9
Publikováno v:
European Journal of Haematology. 58:32-39
Adhesion to cells and matrices participates in the regulation of lymphocyte proliferation, maturation and tissue localization. Consequently, abnormal patterns of adhesion molecule expression may contribute to the pathophysiology of lymphoproliferativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72e3a909891e9c8450e9979aa9df4355
https://doi.org/10.1111/j.1600-0609.1997.tb01407.x
https://doi.org/10.1111/j.1600-0609.1997.tb01407.x
Autor:
S. K. Alex Law, Alister W. Dodds
Publikováno v:
Protein Science. 6:263-274
The covalent binding of complement components C3 and C4 is critical for their activities. This reaction is made possible by the presence of an internal thioester in the native protein. Upon activation, which involves a conformational change initiated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b600744b4e890ace42850a3bf80adaf3
https://doi.org/10.1002/pro.5560060201
https://doi.org/10.1002/pro.5560060201
Autor:
Chi Hang Wong, Suet-Mien Tan, Ardcharaporn Vararattanavech, Man-Li Tang, S. K. Alex Law, Jaume Torres, Hoi-Yeung Li
Publikováno v:
Biochemical Journal. 410:495-502
The current paradigm is that integrin is activated via inside-out signalling when its cytoplasmic tails and TMs (transmembrane helices) are separated by specific cytosolic protein(s). Perturbations of the helical interface between the alpha- and beta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe094b4c56a56a79ff077e2820345ac8
https://doi.org/10.1042/bj20071218
https://doi.org/10.1042/bj20071218
Autor:
Emilia Tng, Gulbu Uzel, Jacqueline Shaw, Martha Kirby, Thomas A. Fleisher, Margaret R. Brown, Jaõ B. Oliveira, Gilda F. Linton, S. K. Alex Law, Sergio D. Rosenzweig, Amy P. Hsu, Mitchell E. Horwitz, Stacie M. Anderson, Steven M. Holland
Publikováno v:
Blood. 111:209-218
Leukocyte adhesion deficiency type-1 (LAD-1) is an autosomal recessive immunodeficiency caused by mutations in the β2 integrin, CD18, that impair CD11/CD18 heterodimer surface expression and/or function. Absence of functional CD11/CD18 integrins on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c989b843c473c37ae8bdaedb79ef00b
https://doi.org/10.1182/blood-2007-04-082552
https://doi.org/10.1182/blood-2007-04-082552
Publikováno v:
Journal of Biological Chemistry. 282:30198-30206
Integrins mediate cell adhesion in response to activation signals that trigger conformational changes within their ectodomain. It is thought that a compact bent conformation of the molecule represents its physiological low affinity state and extended
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cde2d5318f3ceeb185db154f2b23bd0
https://doi.org/10.1074/jbc.m701670200
https://doi.org/10.1074/jbc.m701670200
Leukocyte adhesion deficiency 1 (LAD-1) is caused by defects in the β2 integrin subunit. We studied 18 missense mutations, 14 of which fail to support the surface expression of the β2 integrins. Integrins with the β2-G150D mutation fail to bind li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cf5445867b6d42648766bb9a3a3f580
http://hdl.handle.net/10220/25195
http://hdl.handle.net/10220/25195
Publikováno v:
Biochemical and Biophysical Research Communications. 348:1184-1193
The cell adhesion molecule integrin alphaMbeta2 associates with the urokinase-type plasminogen activator receptor (uPAR) on monocytes and neutrophils. uPAR also associates with members of the beta1 and beta3 integrins, and it modulates the ligand-bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a9738378f46156ee98ac4ef3093285
https://doi.org/10.1016/j.bbrc.2006.07.179
https://doi.org/10.1016/j.bbrc.2006.07.179
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 65:274-279
Part of the interaction between the alpha- and beta-subunits of integrins is known to take place at the transmembrane (TM) domain, where both heteromeric and homomeric aggregates have been reported in vivo and in vitro. In a recent computational stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d0ab0f08eb1cec8a301b8df68d9153
https://doi.org/10.1002/prot.21072
https://doi.org/10.1002/prot.21072
Publikováno v:
FEBS Letters. 580:4435-4442
Integrins are type I heterodimeric (α/β) cell adhesion molecules. They trigger cell-signaling by recruiting cytosolic molecules to their cytoplasmic tails. Integrin α cytoplasmic tail contributes towards integrin function specificity, an important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83dea3f5b5ca360dbde73721cec23e5e
https://doi.org/10.1016/j.febslet.2006.06.099
https://doi.org/10.1016/j.febslet.2006.06.099