Zobrazeno 1 - 10
of 21
pro vyhledávání: '"S. Jordan Kerns"'
Autor:
Michael J. Workman, John P. Gleeson, Elissa J. Troisi, Hannah Q. Estrada, S. Jordan Kerns, Christopher D. Hinojosa, Geraldine A. Hamilton, Stephan R. Targan, Clive N. Svendsen, Robert J. Barrett
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 4, Pp 669-677.e2 (2018)
Background and Aims: Human intestinal organoids derived from induced pluripotent stem cells have tremendous potential to elucidate the intestinal epithelium’s role in health and disease, but it is difficult to directly assay these complex structure
Externí odkaz:
https://doaj.org/article/88440bd53d994589b539e68b40907303
Autor:
Pelin L. Candarlioglu, Sushma Jadalannagari, Jake Chaff, James Velez, Sannidhi R Joshipura, Marianne Kanellias, Alexander P. Simpson, S. Jordan Kerns, Lorna Ewart, Manjunath Hegde, Jason Ekert
Liver plays a vital role in the human immune system, in the internalization and catabolic clearance of therapeutic antibodies and antibody-bound immune complexes via Fc-receptor (FcR) binding on the hepatic reticuloendothelial system cells. This Fc p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d8befb581d9d4c79f28c4c07e7e2293
https://doi.org/10.1101/2022.03.04.482954
https://doi.org/10.1101/2022.03.04.482954
Autor:
Anne Freimoser-Grundschober, Ekaterina Breous-Nystrom, Heather Shannon Grant, Chaitra Belgur, Carina Hage, Anna Maria Giusti, Régine Gérard, Patrick Ray Ng, Martina Geiger, Lauriane Cabon, Adrian Roth, Katia Karalis, Nikolce Gjorevski, Tanja Fauti, Dimitris V. Manatakis, Johannes Sam, Christian Klein, William Tien-Street, Tina Weinzierl, Virginie Micallef, Thomas Singer, Anneliese Schneider, Debora B. Petropolis, Annie Moisan, Peter Bruenker, Jan Eckmann, Geraldine A. Hamilton, S. Jordan Kerns, Cristina Bertinetti-Lapatki, Riccardo Barrile, Michael Bscheider, Marina Bacac, Marianne Kanellias
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3636b0fb4a5bf02fa3e3ab9b2eb29a8
https://doi.org/10.7554/elife.67106.sa2
https://doi.org/10.7554/elife.67106.sa2
Autor:
Marc Hoemberger, Dorothee Kern, Renee Otten, Young-Jin Cho, S. Jordan Kerns, Michael F. Hagan, John B. Stiller
Publikováno v:
Nature Catalysis. 2:726-734
Protein conformational changes are frequently essential for enzyme catalysis, and in several cases, shown to be the limiting factor for overall catalytic speed. However, a structural understanding of corresponding transition states, needed to rationa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8039b0a689716df16477aac2ebec8c5
https://doi.org/10.1038/s41929-019-0307-6
https://doi.org/10.1038/s41929-019-0307-6
Autor:
Katia Karalis, Anneliese Schneider, Riccardo Barrile, Annie Moisan, Peter Bruenker, William Tien-Street, Michael Bscheider, Patrick Ray Ng, Régine Gérard, Tanja Fauti, Anna Maria Giusti, Debora B. Petropolis, Ekaterina Breous-Nystrom, Marina Bacac, Johannes Sam, Thomas Singer, Adrian Roth, Nikolce Gjorevski, Tina Weinzierl, Virginie Micallef, Lauriane Cabon, Dimitris V. Manatakis, Carina Hage, Cristina Bertinetti-Lapatki, Jan Eckmann, Geraldine A. Hamilton, Christian Klein, S. Jordan Kerns, Chaitra Belgur, Marianne Kanellias, Anne Freimoser-Grundschober, Heather Shannon Grant, Martina Geiger
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Traditional drug safety assessment often fails to predict complications in humans, especially when the drug targets the immune system. Here, we show the unprecedented capability of two Organs-on-Chips to evaluate the safety profile of T-cell bispecif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca0bc505b8f7bce39068eca295b02de7
https://pubmed.ncbi.nlm.nih.gov/34558412
https://pubmed.ncbi.nlm.nih.gov/34558412
Autor:
Geraldine A. Hamilton, Marianne Kanellias, Adrian Roth, Ville Kujala, Lorna Ewart, S. Jordan Kerns, Heather Shannon Grant, Katia A. Karalis, Annie Moisan, John Sauld, William Tien-Street, Gjorevski Nikolche
Publikováno v:
Cancer Research. 81:LB066-LB066
T-cell bispecific antibodies (TCBs) are a promising class of immunotherapeutic agents that promote tumor cell killing by physical crosslinking of effector T-cells to target expressing cells. While TCBs are effective in targeting less-immunogenic tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::940bc5584232e9b0435beaf1b4bda359
https://doi.org/10.1158/1538-7445.am2021-lb066
https://doi.org/10.1158/1538-7445.am2021-lb066
Autor:
S. Jordan Kerns, Jeffrey C. Way, David T. Riglar, Roderick T. Bronson, Jonathan W. Kotula, Pamela A. Silver, Matthew J. Niederhuber, Tobias W. Giessen, Michael H. Baym, Georg K. Gerber
Publikováno v:
Nature Biotechnology. 35:653-658
Bacteria can be engineered to function as diagnostics or therapeutics in the mammalian gut but commercial translation of technologies to accomplish this has been hindered by the susceptibility of synthetic genetic circuits to mutation and unpredictab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd7b33f15de79d7c0a05737492e84214
https://doi.org/10.1038/nbt.3879
https://doi.org/10.1038/nbt.3879
Autor:
S. Jordan Kerns, Lynn Bry, Marika Ziesack, Suhyun Kim, Jeffrey C. Way, Pamela A. Silver, Georg K. Gerber
Publikováno v:
ACS synthetic biology. 7(9)
The gut microbiome is intricately involved with establishing and maintaining the health of the host. Engineering of gut microbes aims to add new functions and expand the scope of control over the gut microbiome. To create systems that can perform inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc0cbf56fb80f35349288dba51b96860
https://pubmed.ncbi.nlm.nih.gov/30125499
https://pubmed.ncbi.nlm.nih.gov/30125499
Autor:
Jeffrey C. Way, Pamela A. Silver, S. Jordan Kerns, Marika Ziesack, Lynn Bry, Georg K. Gerber, Suhyun Kim
SummaryThe gut microbiome is intricately involved with establishing and maintaining the health of the host. Engineering of gut microbes aims to add new functions and expand the scope of control over the gut microbiome. To create systems that can perf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19174d4da5187f32de991dd583b5e886
Autor:
Lien A. Phung, Dimitar V. Pachov, Dorothee Kern, Tom Alber, Renee Otten, Roman V. Agafonov, Francesco Pontiggia, Vu Hong Thai, Padraig Niall Murphy, Steffen Kutter, Young-Jin Cho, Michael F. Hagan, S. Jordan Kerns
Publikováno v:
Nature Structural & Molecular Biology. 22:124-131
Kinases perform phosphoryl-transfer reactions in milliseconds; without enzymes, these reactions would take about 8,000 years under physiological conditions. Despite extensive studies, a comprehensive understanding of kinase energy landscapes, includi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98d2665870ef7d2ded2c806a0b8cdf6a
https://doi.org/10.1038/nsmb.2941
https://doi.org/10.1038/nsmb.2941