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pro vyhledávání: '"S. Jonathan Singer"'
Autor:
S. Jonathan Singer
Jonathan Singer's witty, erudite book is a celebration of rationality and an urgent call to make use of intelligence and reason to better cope with human problems. Emphasizing the importance of rationality's greatest achievement, modern science, Sing
Autor:
Nazneen N Dewji, S Jonathan Singer, Eliezer Masliah, Edward Rockenstein, Mihyun Kim, Martha Harber, Taylor Horwood
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0122451 (2015)
β-Amyloid (Aβ) accumulation in the brain is widely accepted to be critical to the development of Alzheimer's disease (AD). Current efforts at reducing toxic Aβ40 or 42 have largely focused on modulating γ-secretase activity to produce shorter, le
Externí odkaz:
https://doaj.org/article/36c4345f68424ce5b55b840fd9b8f93c
Autor:
S. Jonathan Singer
Publikováno v:
Annual Review of Physiology. 66:1-27
▪ Abstract This article is mostly about the beginnings of the molecular biology of membranes, covering the decade 1964–1974. It is difficult to read (or write) this article because of a sense of déja vu. Most of the material in it is considered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6492b628829cf4dfb03daf0d7d26bec2
https://doi.org/10.1146/annurev.physiol.66.032902.131835
https://doi.org/10.1146/annurev.physiol.66.032902.131835
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 103(5)
We have earlier proposed that a cell-cell interaction, mediated by the specific binding of molecules of the beta-amyloid precursor protein (beta-APP) on one cell surface with molecules of presenilin (PS) on the other cell surface, is a required initi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eae7369045fe745253489480e9ddec4
https://pubmed.ncbi.nlm.nih.gov/16432203
https://pubmed.ncbi.nlm.nih.gov/16432203
Autor:
Nazneen N. Dewji, S. Jonathan Singer
Although there is a growing body of evidence that different amyloidoses may have a similar molecular mechanism in common, the many details of this mechanism are not understood. In this study, we propose that there is a common molecular structure of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b087e43eb94929e7144fc141205fd07d
https://europepmc.org/articles/PMC1345708/
https://europepmc.org/articles/PMC1345708/
Autor:
S. Jonathan Singer, Nazneen N. Dewji
Publikováno v:
Science. 271:159-159
All cases of familial Alzheimer9s disease are caused by mutations in either the gene for beta-amyloid precursor protein or the protein S182/STM. The normal functions of these transmembrane proteins are unknown, and it is unclear how they relate to on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0a953fdb25adae48a7a8974a7ca5e6a
https://doi.org/10.1126/science.271.5246.159
https://doi.org/10.1126/science.271.5246.159
Autor:
S. Jonathan Singer
Publikováno v:
Biochemical Society Transactions. 9:203-206
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::042389f1ffd5b64f4086cb1e63381cc4
https://doi.org/10.1042/bst0090203
https://doi.org/10.1042/bst0090203