Zobrazeno 1 - 10
of 104
pro vyhledávání: '"S. John Gatley"'
Autor:
Carol A. Paronis, S. John Gatley, Girish Chopda, Viraj Parge, Ganesh A. Thakur, Alexandros Makriyannis
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 358:334-341
Daily treatment with cannabinoids results in tolerance to many, but not all, of their behavioral and physiologic effects. The present studies investigated the effects of 7-day exposure to 10 mg/kg daily of Δ(9)-tetrahydrocannabinol (THC) on the diur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fd3a85143d2659ce6878984c0e53cfa
https://doi.org/10.1124/jpet.116.232132
https://doi.org/10.1124/jpet.116.232132
Autor:
Clinton E. Hagen, S. John Gatley, Timothy R. DeGrado, Mark Jacobson, Kun Qian, Mukesh K. Pandey, Richard I. Duclos
Publikováno v:
ACS Chemical Neuroscience. 5:793-802
N-Acylethanolamines are lipid signaling molecules found throughout the plant and animal kingdoms. The best-known mammalian compound of this class is anandamide, N-arachidonoylethanolamine, one of the endogenous ligands of cannabinoid CB1 and CB2 rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2dc3f7345b434c5599592076b21031b
https://doi.org/10.1021/cn400214j
https://doi.org/10.1021/cn400214j
Autor:
Shachi R. Bhatt, Jay A. A. West, Surina Sikka, Alexandros Makriyannis, Richard I. Duclos, S. John Gatley, Meghan Johnston, Richard W. Mercier
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:4585-4592
A series of N-formyl-α-amino acid esters of β-lactone derivatives structurally related to tetrahydrolipstatin (THL) and O-3841 were synthesized that inhibit human and murine diacylglycerol lipase (DAGL) activities. New ether lipid reporter compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c49cb3b54ec252a2f1f54849bbd8813
https://doi.org/10.1016/j.bmcl.2012.05.101
https://doi.org/10.1016/j.bmcl.2012.05.101
Publikováno v:
Neuroscience. 303
Previous studies have shown that glial cell line-derived neurotrophic factor (GDNF) exerts significant neuroprotective effects on substantia nigra (SN) neurons in the rat 6-hydroxydopamine (6-OHDA) model of Parkinson's disease (PD). In this study we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcffa8c6dee3afcfcdf3a9f454069abd
https://pubmed.ncbi.nlm.nih.gov/26166725
https://pubmed.ncbi.nlm.nih.gov/26166725
Autor:
Dinko Franceschi, S. John Gatley, George Kunos, Ting-Kai Li, Panayotis K. Thanos, Nora D. Volkow, Gene-Jack Wang, Christopher Wong, Joanna S. Fowler, Richard L. Veech, Laurence Maynard
Publikováno v:
NeuroImage. 29:295-301
Moderate doses of alcohol decrease glucose metabolism in the human brain, which has been interpreted to reflect alcohol-induced decreases in brain activity. Here, we measure the effects of two relatively low doses of alcohol (0.25 g/kg and 0.5 g/kg,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::617a856ed151b86495bf468c236f924f
https://doi.org/10.1016/j.neuroimage.2005.07.004
https://doi.org/10.1016/j.neuroimage.2005.07.004
Candidate PET radioligands for cannabinoid CB1 receptors: [18F]AM5144 and related pyrazole compounds
Autor:
Andrew N. Gifford, Zizhong Li, Rajesh Thotapally, Qian Liu, Alexandros Makriyannis, Yu-Shin Ding, S. John Gatley
Publikováno v:
Nuclear Medicine and Biology. 32:361-366
The mammalian brain contains abundant G protein-coupled cannabinoid CB(1) receptors that respond to Delta(9)-tetrahydrocannabinol, the active ingredient of cannabis. The availability of a positron emission tomography (PET) radioligand would facilitat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cda9dd7b60d3c4ba85e4e88b9443df6b
https://doi.org/10.1016/j.nucmedbio.2005.02.007
https://doi.org/10.1016/j.nucmedbio.2005.02.007
Autor:
Nora D. Volkow, Paul Vaska, David J. Schlyer, Richard A. Ferrieri, Jean Logan, Yu-Shin Ding, Victor Garza, Colleen Shea, Wei Zhu, Frank Telang, Gene-Jack Wang, Youwen Xu, David Alexoff, Joanna S. Fowler, S. John Gatley, Zizhong Li
Publikováno v:
Nuclear Medicine and Biology. 31:313-319
The monoamine oxidase A and B (MAO A and B) radiotracers [(11)C]clorgyline (CLG) and [(11)C]L-deprenyl (DEP) and their deuterium labeled counterparts (CLG-D and DEP-D) were compared to determine whether their distribution and kinetics in humans are c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c31dd37648c015dabd97d1026269d05
https://doi.org/10.1016/j.nucmedbio.2003.10.003
https://doi.org/10.1016/j.nucmedbio.2003.10.003
Autor:
Millard Jayne, Colleen Shea, David J. Schlyer, Yu-Shin Ding, Youwen Xu, Noelwah Netusil, Gene-Jack Wang, Paul Vaska, Frank Telang, Richard A. Ferrieri, Jean Logan, Donald Warner, Nora D. Volkow, Victor Garza, Dinko Franceschi, Joanna S. Fowler, Pauline Carter, Payton King, Wei Zhu, Naomi Pappas, S. John Gatley, David Alexoff
Publikováno v:
Proceedings of the National Academy of Sciences. 100:11600-11605
One of the major mechanisms for terminating the actions of catecholamines and vasoactive dietary amines is oxidation by monoamine oxidase (MAO). Smokers have been shown to have reduced levels of brain MAO, leading to speculation that MAO inhibition b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96a0fb47a16b0b46ff9cb7c80180691f
https://doi.org/10.1073/pnas.1833106100
https://doi.org/10.1073/pnas.1833106100
Autor:
Andrew N. Gifford, Gene-Jack Wang, Nora D. Volkow, S. John Gatley, Yu-Shin Ding, Jean Logan, Joanna S. Fowler
Publikováno v:
Drug Development Research. 59:194-207
The development of positron emission tomography (PET) and the ability to synthesize compounds labeled with the short-lived positron emitters 11C and 18F has made possible the imaging and quantification of drug binding sites in the human body. By cond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a350c7efc1d906825d065a4616cca28
https://doi.org/10.1002/ddr.10219
https://doi.org/10.1002/ddr.10219
Autor:
Paul Vaska, David Alexoff, Richard A. Ferrieri, Yu-Shin Ding, Wei Zhu, S. John Gatley, Nora D. Volkow, Naomi Pappas, David J. Schlyer, Gene-Jack Wang, Noelwah Netusil, Youwen Xu, Dinko Franceschi, Colleen Shea, Pauline Carter, Millard Jayne, Jean Logan, Donald Warner, Victor Garza, Frank Telang, Payton King, Joanna S. Fowler
Publikováno v:
Synapse. 49:178-187
Monoamine oxidase (MAO) catalyzes the oxidative deamination of many biogenic and dietary amines. Though studies of MAO have focused mainly on its regulatory role in the brain, MAO in peripheral organs also represents a vast mechanism for detoxifying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a2e97f43fdd42c261f1c8ada88f034
https://doi.org/10.1002/syn.10231
https://doi.org/10.1002/syn.10231