Zobrazeno 1 - 10
of 47
pro vyhledávání: '"S. John Curnow"'
Autor:
Alexander Roberts, Lindsay Bentley, Tina Tang, Fay Stewart, Chiara Pallini, Joel Juvvanapudi, Graham R. Wallace, Alison J. Cooper, Aaron Scott, David Thickett, Sebastian T. Lugg, Hollie Bancroft, Bridget Hemming, Charlotte Ferris, Gerald Langman, Andrew Robinson, Joanne Chapman, Babu Naidu, Thomas Pinkney, Graham S. Taylor, Kristian Brock, Zania Stamataki, Catherine A. Brady, S. John Curnow, John Gordon, Omar Qureshi, Nicholas M. Barnes
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Blockade of PD-1/PD-L1 interactions is proving an exciting, durable therapeutic modality in a range of cancers whereby T cells are released from checkpoint inhibition to revive their inherent anti-tumour activity. Here we have studied variou
Externí odkaz:
https://doaj.org/article/17d4c012af55407c96c408b8c553e796
Autor:
Omar S. Qureshi, Fay Stewart, Andrew C Robinson, Charlotte Ferris, Nicholas M. Barnes, Zania Stamataki, Sebastian T Lugg, Aaron Scott, Tina Tang, Gerald Langman, Chiara Pallini, John R. Gordon, Thomas Pinkney, Alexander Roberts, Lindsay Bentley, David R Thickett, S. John Curnow, A.J Cooper, Graham S. Taylor, Kristian Brock, Bridget Hemming, Catherine A. Brady, Hollie Bancroft, Joanne Chapman, Babu Naidu, Joel Juvvanapudi, Graham R. Wallace
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Blockade of PD-1/PD-L1 interactions is proving an exciting, durable therapeutic modality in a range of cancers whereby T cells are released from checkpoint inhibition to revive their inherent anti-tumour activity. Here we have studied various ways to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d080e0bed706b07d23b8995acc8c24f2
https://doi.org/10.1038/s41598-021-83612-3
https://doi.org/10.1038/s41598-021-83612-3
Supplemental material, MSO899695 Supplemental Figure for Th17 cells increase in RRMS as well as in SPMS, whereas various other phenotypes of Th17 increase in RRMS only by S Kalra, C Lowndes, L Durant, RC Strange, A Al-Araji, Clive P Hawkins and S Joh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20c4353af09dad53f1b8e4a772fb61a6
Autor:
C Lowndes, Seema Kalra, Richard C. Strange, Clive Hawkins, S. John Curnow, Lindsay Durant, A Al-Araji
Publikováno v:
Multiple Sclerosis Journal-Experimental, Translational and Clinical
Background The nature and extent of inflammation seen in multiple sclerosis (MS) varies throughout the course of the disease. Changes seen in CD4+ T-helper cells in relapsing–remitting (RR) MS and secondary progressive (SP) MS might differ qualitat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4c5155ce728fd6fb7ac6d2f108a7c39
http://europepmc.org/articles/PMC6990617
http://europepmc.org/articles/PMC6990617
Supplemental material, MSO899695 Supplemental material for Th17 cells increase in RRMS as well as in SPMS, whereas various other phenotypes of Th17 increase in RRMS only by S Kalra, C Lowndes, L Durant, RC Strange, A Al-Araji, Clive P Hawkins and S J
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a66da607c871f200bf9b6b74ad8bfa9
Autor:
S John Curnow, Marianne Fairclough, Caroline Schmutz, Steve Kissane, Alastair K O Denniston, Kate Nash, Christopher D Buckley, Janet M Lord, Mike Salmon
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9730 (2010)
Fibrocytes are bone-marrow derived cells, expressing both haematopoietic and stromal cell markers, which contribute to tissue repair as well as pathological fibrosis. The differentiation of fibrocytes remains poorly characterised and this has limited
Externí odkaz:
https://doaj.org/article/aed10a1ff9e043ce8357aaef4e1da794
Autor:
Andrzej Kutner, John R. Gordon, S. John Curnow, Gillian Grafton, Paweł Kozielewicz, Nicholas M. Barnes
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 164:98-105
Calcitriol (1,25-dihydroxyvitamin D3, 1,25D3) and vitamin D side-chain modified analogs (VDAs) have gained considerable attention as potential drugs in the treatment of acute myeloid leukemia (AML), yet studies of the impact of 1,25D3 and VDAs upon o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8dbd1c458bb47fc4182dad70dd85384
https://doi.org/10.1016/j.jsbmb.2015.10.015
https://doi.org/10.1016/j.jsbmb.2015.10.015
Autor:
Emma, Rathbone, Lindsay, Durant, James, Kinsella, Antony R, Parker, Ghaniah, Hassan-Smith, Michael R, Douglas, S John, Curnow
Publikováno v:
Journal of neurology, neurosurgery, and psychiatry. 89(10)
To determine whether the ratio of cerebrospinal fluid (CSF) immunoglobulin kappa to lambda light chains at time of multiple sclerosis (MS) diagnosis predicts disease progression and whether this was intrinsic to CSF plasmablasts.CSF and peripheral bl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::13ab6832e63afdae6cf766262cb07826
https://pubmed.ncbi.nlm.nih.gov/29764926
https://pubmed.ncbi.nlm.nih.gov/29764926
Autor:
Graham R. Wallace, Jawaher A. Alsalem, S. John Curnow, Philip I. Murray, Robert J Barry, Juliet Faassen
Publikováno v:
British Journal of Ophthalmology. 99:696-699
Transforming growth factor β (TGFβ) is an important immunoregulatory cytokine in regulatory T cell (Treg) and Th17-mediated pathology, including uveitis due to Behçet's disease (BD). Of the three isoforms, TGFβ2 is found at highest levels in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6763d05aacba218ef25b28d43b947b4a
https://doi.org/10.1136/bjophthalmol-2014-306198
https://doi.org/10.1136/bjophthalmol-2014-306198
Autor:
Michelle B. Paget, Khalid M. Qureshi, Jou Lee, R. Downing, Clifford J. Bailey, S. John Curnow, Hilary E. Murray
Publikováno v:
Clinical Transplantation. 29:90-98
Modification of human islets prior to transplantation may improve long-term clinical outcome in terms of diabetes management, by supporting graft function and reducing the potential for allo-rejection. Intragraft incorporation of stem cells secreting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaf57a3317a2b58fda11624e6560301c
https://doi.org/10.1111/ctr.12488
https://doi.org/10.1111/ctr.12488