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Comparison of pharmacokinetics and bioavailability of bedaquiline fumarate, benzoate and maleate in dogs

Autor: S. Jaw-Tsai, R. Barry, P. G. Pande, R. Taneja, T. Yang

Publikováno v: The International Journal of Tuberculosis and Lung Disease. 27:28-33

BACKGROUND: Bedaquiline (BDQ) as a fumarate salt is indicated as part of a regimen to treat multidrug-resistant TB (MDR-TB). BDQ benzoate and maleate have been identified as promising alternatives that will encourage generic pharmaceutical houses to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::beea2b36f4a4baed17d869615dd7b5e4
https://doi.org/10.5588/ijtld.22.0326

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Akademický článek

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In Vivo Pharmacological Characterization of TD-4208, a Novel Lung-Selective Inhaled Muscarinic Antagonist with Sustained Bronchoprotective Effect in Experimental Animal Models

Autor: S. Jaw-Tsai, MT Pulido-Rios, Sharath S. Hegde, William J. Martin, Yuhua Ji, Alexander McNamara, Glenmar P. Obedencio

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 346:241-250

Tiotropium is currently the only once-daily, long-acting muscarinic antagonist (LAMA) approved in the United States and other countries for the treatment of chronic obstructive pulmonary disease (COPD). Glycopyrronium has shown promise as a LAMA and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fee814ddda2b900ee4e73ec56cb80eb
https://doi.org/10.1124/jpet.113.203554

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AZD-3043

Autor: Scott C. Steffensen, Shinju Obara, Sarah S. Jaw-Tsai, David T. Beattie, Talmage D. Egan, Daniel R. Cook, Shanti M. Amagasu, Thomas E. Jenkins

Publikováno v: Anesthesiology. 116:1267-1277

Background Propofol can be associated with delayed awakening after prolonged infusion. The aim of this study was to characterize the preclinical pharmacology of AZD-3043, a positive allosteric modulator of the γ-aminobutyric acid type A (GABA(A)) re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1d776f11f5e59db694ebd206680ee8f1
https://doi.org/10.1097/aln.0b013e31825685a6

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Antiparkinsonian Actions of CP-101,606, an Antagonist of NR2B Subunit-Containing N-Methyl-d-Aspartate Receptors

Autor: Sarah S. Jaw-Tsai, Kathy Steece-Collier, Frank S. Menniti, J. Timothy Greenamyre, Leslie K. Chambers

Publikováno v: Experimental Neurology. 163:239-243

In the setting of nigrostriatal dopamine depletion, glutamatergic pathways to the striatum and basal ganglia output nuclei become overactive. Systemically administered glutamate receptor antagonists may have direct antiparkinsonian actions in rodents

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::104bf284985352cffa61bcbcb3b598e2
https://doi.org/10.1006/exnr.2000.7374

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AZD-3043: a novel, metabolically labile sedative-hypnotic agent with rapid and predictable emergence from hypnosis

Autor: Talmage D, Egan, Shinju, Obara, Thomas E, Jenkins, Sarah S, Jaw-Tsai, Shanti, Amagasu, Daniel R, Cook, Scott C, Steffensen, David T, Beattie

Publikováno v: Anesthesiology. 116(6)

Propofol can be associated with delayed awakening after prolonged infusion. The aim of this study was to characterize the preclinical pharmacology of AZD-3043, a positive allosteric modulator of the γ-aminobutyric acid type A (GABA(A)) receptor cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::89d4ccc54e31798e8f5b31e6a72f7ead
https://pubmed.ncbi.nlm.nih.gov/22531340

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