Zobrazeno 1 - 10
of 24
pro vyhledávání: '"S. Jane deSolms"'
Autor:
J. Christopher Culberson, Steven M. Pitzenberger, Charles A. Omer, Michael J. Bogusky, Scott D. Mosser, Kenneth S. Koblan, S. Jane Desolms, E A Giuliani
Publikováno v:
Protein Science. 4:681-688
Farnesyl-protein transferase (FPTase) catalyzes the posttranslational farnesylation of the cysteine residue located in the carboxyl-terminal tetrapeptide of the Ras oncoprotein. Prenylation of this residue is essential for the membrane association an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51f0fe75826118ddc05251871d2f8ece
https://doi.org/10.1002/pro.5560040408
https://doi.org/10.1002/pro.5560040408
Autor:
Anthony W. Shaw, S. Jane Desolms
Publikováno v:
Tetrahedron Letters. 42:7173-7176
Organometallic addition to tert -butanesufinyl ketimines derived from diaryl and aryl-heteroaryl ketones provided the corresponding α,α-diaryl and α-aryl-α-heteroaryl alkylamines in good yield with high diastereoselectivity. In many cases, imine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7d51886c659268f673a1ea27879d928
https://doi.org/10.1016/s0040-4039(01)01513-1
https://doi.org/10.1016/s0040-4039(01)01513-1
Autor:
John S. Wai, Jiunn H. Lin, Cuyue Tang, William E Neway, Christopher J. Dinsmore, Masato Chiba, S. Jane Desolms, Theresa M. Williams
Publikováno v:
Biochemical Pharmacology. 62:773-776
Methyl substitution at the 2-position of the imidazole ring greatly improved drug metabolism profiles, in human liver microsomes, of ras farnesyl-protein transferase inhibitor (FTI) candidates for drug development. Methyl substitution markedly reduce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d02cc063ae7bfba5ea586dc27a0b866
https://doi.org/10.1016/s0006-2952(01)00724-9
https://doi.org/10.1016/s0006-2952(01)00724-9
Autor:
Joseph P. Davide, Robert B. Lobell, Kelly Hamilton, Kenneth S. Koblan, Ronald G. Robinson, Nancy E. Kohl, S. Jane Desolms, Samuel L. Graham, S. C. Mactough, John H. Hutchinson, Anthony W. Shaw, Terrence M. Ciccarone, Marc Abrams
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:1257-1260
Imidazolemethyl diaryl ethers are potent inhibitors of farnesyl-protein transferase. The SNAr displacement reaction used to prepare these diaryl ethers was amenable to rapid parallel synthesis of FPTase inhibitors. The use of a broad range of commerc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a97313784c223cafc9cb62933fc9a131
https://doi.org/10.1016/s0960-894x(01)00162-7
https://doi.org/10.1016/s0960-894x(01)00162-7
Autor:
Michael J. Breslin, Kelly Hamilton, Samuel L. Graham, E A Giuliani, G. E. Stokker, David L. Pompliano, John H. Hutchinson, Scott D. Mosser, S. Jane Desolms
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:3311-3316
The structure-activity relationship of a series of non-thiol CaaX analogs, which are inhibitors of farnesyltransferase, is described. These inhibitors contain a substituted phenyl group at the N terminus, which may occupy a novel binding domain on th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87d93e1070c8072e77c707fb34dbcc7a
https://doi.org/10.1016/s0960-894x(98)00586-1
https://doi.org/10.1016/s0960-894x(98)00586-1
Autor:
Jackson B. Gibbs, Oliff Allen I, S. Jane Desolms, Laura Sepp-Lorenzino, Kenneth S. Koblan, Nancy E. Kohl, Neal Rosen, Michael W. Conner, Samuel L. Graham, Theresa M. Williams, Charles A. Omer, George D. Hartman, Neville J. Anthony
Publikováno v:
Breast Cancer Research and Treatment. 38:75-83
The oncoprotein encoded by mutant ras genes is initially synthesized as a cytoplasmic precursor which requires posttranslational processing to attain biological activity; farnesylation of the cysteine residue present in the CaaX motif located at the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d7f966103ff0a65bf19e1421631b907
https://doi.org/10.1007/bf01803786
https://doi.org/10.1007/bf01803786
Autor:
Nancy E. Kohl, Charles A. Omer, Michael W. Conner, Neville J. Anthony, Joseph P. Davide, S. Jane Desolms, Elizabeth A. Giuliani, Robert P. Gomez, Samuel L. Graham, Kelly Hamilton, Laurence K. Handt, George D. Hartman, Kenneth S. Koblan, Astrid M. Kral, Patricia J. Miller, Scott D. Mosser, Timothy J. O'Neill, Elaine Rands, Michael D. Schaber, Jackson B. Gibbs, Allen Oliff
Publikováno v:
Nature Medicine. 1:792-797
For Ras oncoproteins to transform mammalian cells, they must be post-translationally modified with a farnesyl group in a reaction catalysed by the enzyme farnesyl-protein transferase (FPTase). Inhibitors of FPTase have therefore been proposed as anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0382a1f38fff17a314a1bd3e4fdea51b
https://doi.org/10.1038/nm0895-792
https://doi.org/10.1038/nm0895-792
Autor:
G. E. Stokker, Samuel L. Graham, John H. Hutchinson, Michael J. Breslin, S. Jane Desolms, E A Giuliani, Scott D. Mosser, Hamilton Kelly A. Hamilton Kelly A., David L. Pompliano
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edbb0a862ca932b5cfd24c7b4609e61d
https://doi.org/10.1002/chin.199911233
https://doi.org/10.1002/chin.199911233
Autor:
Anthony W. Shaw, S. Jane Desolms
Publikováno v:
ChemInform. 32
Organometallic addition to tert -butanesufinyl ketimines derived from diaryl and aryl-heteroaryl ketones provided the corresponding α,α-diaryl and α-aryl-α-heteroaryl alkylamines in good yield with high diastereoselectivity. In many cases, imine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a10dadf3667be93b0495695478cf10c5
https://doi.org/10.1002/chin.200151112
https://doi.org/10.1002/chin.200151112
Autor:
Nancy E. Kohl, Charles A. Omer, Ronald E. Diehl, S. Jane deSolms, Theresa M. Williams, Astrid M. Kral
Publikováno v:
The Journal of biological chemistry. 272(43)
The roles of 11 conserved amino acids of the beta-subunit of human farnesyl:protein transferase (FTase) were examined by performing kinetic and biochemical analyses of site-directed mutants. This biochemical information along with the x-ray crystal s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa8d5112f59698bbea44d63c68ff348
https://pubmed.ncbi.nlm.nih.gov/9341181
https://pubmed.ncbi.nlm.nih.gov/9341181