Zobrazeno 1 - 10
of 123
pro vyhledávání: '"S. James Adelstein"'
Publikováno v:
Molecules, Vol 13, Iss 2, Pp 391-404 (2008)
Most cancer therapeutics (chemo, radiation, antibody-based, anti-angiogenic)are at best partially and/or temporarily effective. In general, the causes for failure can besummarized as: (i) poor diffusion and/or nonuniform distribution of drug/prodrugm
Externí odkaz:
https://doaj.org/article/611f80ec12ac4a7f97e1498fb3a5a569
Publikováno v:
Molecular Imaging, Vol 10 (2011)
Molecular imaging has moved to the forefront of drug development and biomedical research. The identification of appropriate imaging targets has become the touchstone for the accurate diagnosis and prognosis of human cancer. Particularly, cell surface
Externí odkaz:
https://doaj.org/article/843287bb7c5741a68a323fa2cc1fdf83
Publikováno v:
PLoS ONE, Vol 4, Iss 1 (2009)
Externí odkaz:
https://doaj.org/article/a9d338c34b254c40ac229751ae8d5204
Autor:
S. James Adelstein, Kenneth R. Kase
Publikováno v:
Journal of Radiological Protection. 38:873-875
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fd454d8c44172824d50813d36cd4f73
https://doi.org/10.1088/1361-6498/aaaed4
https://doi.org/10.1088/1361-6498/aaaed4
Publikováno v:
Drug Discovery Today. 17:S16-S23
Data mining of available biomedical data and information has greatly boosted target discovery in the 'omics' era. Target discovery is the key step in the biomarker and drug discovery pipeline to diagnose and fight human diseases. In biomedical scienc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44e2e402fca927ede865cbc70da165a3
https://doi.org/10.1016/j.drudis.2011.12.006
https://doi.org/10.1016/j.drudis.2011.12.006
Publikováno v:
Chemical Biology & Drug Design. 78:923-931
Human placental alkaline phosphatase has been identified as a hydrolase that is significantly overexpressed on the surface of various solid tumor cells, and is therefore a suitable prodrug design target for non-invasive cancer imaging and therapy. St
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05ab20a47f59f6ca3a5eba9fd8fc6040
https://doi.org/10.1111/j.1747-0285.2011.01238.x
https://doi.org/10.1111/j.1747-0285.2011.01238.x
Publikováno v:
Analytical Biochemistry. 417:242-246
The widely used agarose gel electrophoresis method for assessing radiation-induced single-strand-break (SSB) yield in plasmid DNA involves measurement of the fraction of relaxed-circular (C) form that migrates independently from the intact supercoile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3eb402fd8ccf463849b5bc0ffae307c2
https://doi.org/10.1016/j.ab.2011.06.023
https://doi.org/10.1016/j.ab.2011.06.023
Publikováno v:
Journal of Nuclear Medicine. 52:1240-1251
The value of pediatric nuclear medicine is well established. Pediatric patients are referred to nuclear medicine from nearly all pediatric specialties including urology, oncology, cardiology, gastroenterology, and orthopedics. Radiation exposure is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98868ec57a2b1287506914699ecb564f
https://doi.org/10.2967/jnumed.109.069609
https://doi.org/10.2967/jnumed.109.069609
Autor:
David J. Brenner, Mark S. Pearce, Eric J. Hall, Louis K. Wagner, Donald P. Frush, James H. Thrall, Cynthia H. McCollough, Fred A. Mettler, Hedvig Hricak, S. James Adelstein, Roger W. Howell, Orhan H. Suleiman
Publikováno v:
Radiology. 258:889-905
This special report aims to inform the medical community about the many challenges involved in managing radiation exposure in a way that maximizes the benefit-risk ratio. The report discusses the state of current knowledge and key questions in regard
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dc4149e15a208cebaf2316ec592747e
https://doi.org/10.1148/radiol.10101157
https://doi.org/10.1148/radiol.10101157
Publikováno v:
Expert Review of Molecular Diagnostics. 10:65-74
Prostate cancer is the most common cancer among men worldwide and is the second leading cause of death among those over 50 years of age in the USA. However, many men who develop a prostate tumor never exhibit symptoms in the early stage of the diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::406488095287b4185052fce8b4a7db70
https://doi.org/10.1586/erm.09.73
https://doi.org/10.1586/erm.09.73