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pro vyhledávání: '"S. J. Roberts‑Thomson"'
Autor:
Felicity M. Davis, Iman Azimi, S. J. Roberts‑Thomson, Gregory R. Monteith, Thomas J. Gonda, Erik W. Thompson, S. Y. N. Jamaludin, Amelia A. Peters
Publikováno v:
Jamaludin, S Y N, Azimi, I, Davis, F M, Peters, A A, Gonda, T J, Thompson, E W, Roberts-Thomson, S J & Monteith, G R 2018, ' Assessment of CXC ligand 12-mediated calcium signalling and its regulators in basal-like breast cancer cells ', Oncology Letters, vol. 15, no. 4, pp. 4289-4295 . https://doi.org/10.3892/ol.2018.7827
Oncology Letters
Oncology Letters
CXC ligand (L)12 is a chemokine implicated in the migration, invasion and metastasis of cancer cells via interaction with its receptors CXC chemokine receptor (CXCR)4 and CXCR7. In the present study, CXCL12-mediated Ca2+ signalling was compared with
Publikováno v:
Nutrition and cancer. 31(3)
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a carcinogenic heterocyclic amine derived from cooked meat. Mammary gland tumors were induced in female Sprague-Dawley rats given 10 doses of PhIP (75 mg/kg po) once per day from 43 days of ag
Autor:
S J, Roberts-Thomson, E G, Snyderwine
Publikováno v:
Molecular carcinogenesis. 20(4)
Activating mutations in and expression of the Ha-ras gene were examined in benign and malignant female Sprague-Dawley rat mammary gland tumors induced by the heterocyclic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and promoted by a
Publikováno v:
Molecular pharmacology. 49(1)
In the present study, we studied the regioselectivity and stereoselectivity of human microsomal epoxide hydrolase-catalyzed hydration of the enantiomers of the polycyclic aza-aromatic hydrocarbon K-region oxide, 7-methylbenz[c]acridine-5,6-oxide. We
Metabolism of polycyclic aza-aromatic carcinogens catalyzed by four expressed human cytochromes P450
Publikováno v:
Cancer research. 55(5)
The role of human cytochromes P4501A1, -1A2, -3A4, and -3A5 in the metabolism of the polycyclic aza-aromatic hydrocarbons 7-methylbenz(c)acridine and dibenz(aj)acridine was investigated. The regioselectivity of the reactions was determined, as well a