Zobrazeno 1 - 5
of 5
pro vyhledávání: '"S. J. Ochalski"'
Publikováno v:
Inflammation Research. 47:339-344
Objective and Design: To determine whole blood levels of sirolimus, a macrolide antibiotic in the rat developing adjuvant arthritis (AA) model after dosing orally with two different vehicles, and whether combinational doses of sirolimus and cyclospor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb1bc9cb6c0a7352e2a77380df15cea9
https://doi.org/10.1007/s000110050339
https://doi.org/10.1007/s000110050339
Publikováno v:
Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 44(7)
IL-1 beta, IL-8, IL-6 and TNF alpha, derived from infiltrating leukocytes, are important mediators of inflammation in arthritic and allergic diseases. Heparinized human whole blood was evaluated as a model to study the effects of various classes of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5926ddbd3ec6940e5bfc2aafbf6175aa
https://pubmed.ncbi.nlm.nih.gov/8564522
https://pubmed.ncbi.nlm.nih.gov/8564522
Publikováno v:
Agents and actions.
Intraperitoneal injection of lipopolysaccharide (LPS) was used to elicit a sublethal, shock-like condition in mice. LPS, 2.5 mg/kg i.p., induced hypothermia, elevated serum TNF-alpha levels and lethality over a 48 h period in male CD-1 mice. The 5-li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09647b8bce9d860ac45403f3cddc45c8
https://pubmed.ncbi.nlm.nih.gov/8273585
https://pubmed.ncbi.nlm.nih.gov/8273585
Publikováno v:
Agents and actions.
PEM-420, the active isomer of pemedolac, inhibited the writhing responses induced by phenylbenzoquinone (PBQ), acetic acid, and acetylcholine in mice with ED50's of 0.80, 0.92, and 0.075 mg/kg p.o., respectively. In the rat acetic acid writhing assay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c72902c4f43207cc22302cb2fdad1124
https://pubmed.ncbi.nlm.nih.gov/8273576
https://pubmed.ncbi.nlm.nih.gov/8273576
Publikováno v:
Agents and actions.
Heparinized human whole blood was evaluated as a model to study the effects of various classes of anti-inflammatory drugs on IL-1 beta and TNF-alpha release from leukocytes. Human whole blood was stimulated with zymosan (1.5 mg/ml) or LPS (5 microgra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5460977b3aea21e80081a74d7e4e1e16
https://pubmed.ncbi.nlm.nih.gov/8273590
https://pubmed.ncbi.nlm.nih.gov/8273590