Zobrazeno 1 - 10
of 57
pro vyhledávání: '"S. J. Mustafa"'
Objective Sex plays an important role in the pathophysiology of cardiovascular diseases. This study aims to investigate how sex impacts on the coronary flow regulation during atherosclerosis. Methods ApoE KO mouse fed with western diet were used for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4efd6fad5f479c24e151f0954beb6ce3
https://europepmc.org/articles/PMC4583352/
https://europepmc.org/articles/PMC4583352/
Publikováno v:
The FASEB Journal. 29
Soluble epoxide hydrolase (sEH) degrades epoxyeicosatrienoic acids (EETs) to less active diols (dihydroxyeicosatrienoic acids; DHETs). EETs are endothelium-derived hyperpolarizing factors (EDHFs) w...
Publikováno v:
The FASEB Journal. 29
Gender plays an important role in the pathophysiology of cardiovascular diseases. Coronary endothelial dysfunction is a critical stage in the pathogenesis of artherosclerosis. This study aims to in...
Publikováno v:
The FASEB Journal. 29
Bolus injections of adenosine (ADO) and A2A selective adenosine (regadenoson) are used clinically as a substitute for stress test in people who can't exercise. Using different isolated tissue preparations, our lab has shown that coronary blood flow (
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 279:H650-H656
We investigated the role of the cAMP link to the signal transduction mechanism coupled with adenosine A2Aand A2Breceptors in cultured human coronary artery endothelial cells (HCAEC) and porcine coronary artery endothelial cells (PCAEC). 2-[4-[2-{2-[(
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 273:L581-L587
In this study, we investigated the relaxant effect of adenosine receptor agonists on KCl-precontracted airway smooth muscle from rabbits and characterized the type of receptor involved in bronchorelaxation in the presence and absence of epithelium. W
Publikováno v:
Physiological Reports. 1
Adenosine receptors (AR; A1 ,A 2A ,A 2B, and A3) contract and relax smooth muscle through different signaling mechanisms. Deciphering these complex responses remains difficult because relationships between AR subtypes and various end-effectors (e.g.,
Autor:
H. A. Olanrewaju, S. J. Mustafa
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 270:H134-H141
This study evaluates the relaxing effects of adenosine analogues in relation to intracellular free Ca2+ concentration ([Ca2+]i) in porcine coronary artery. Changes in muscle tension and [Ca2+]i were measured simultaneously using the fluorescent Ca2+
Autor:
R. B. Marala, S. J. Mustafa
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 269:H1619-H1624
Biochemical and pharmacological studies have established that adenosine modulates protein kinase C (PKC), which plays an important role in the maintenance of vascular tone. Our earlier studies [Marala and Mustafa. Am. J. Physiol. 268 (Heart Circ. Phy
Publikováno v:
Bioconjugate Chemistry. 5:364-369
The design, synthesis, and receptor subtype binding affinities of several 2-substituted thioadenosine nucleoside and nucleotide analogues are described. Alkylation of 2-thioadenosine (1) with iodopentenylboronic acid followed by iododeboronation gave