Zobrazeno 1 - 10
of 25
pro vyhledávání: '"S. J. Mihic"'
Autor:
Jonathan T. Pierce, S. J. Mihic, Ashley E. Philpo, Elliott J. Brecht, Luisa L. Scott, Sangeetha Iyer, N. S. Wu, Richard W. Aldrich, Joseph P. Walton
Publikováno v:
Scientific Reports
Large conductance calcium-activated (BK) channels are broadly expressed in neurons and muscle where they modulate cellular activity. Decades of research support an interest in pharmaceutical applications for modulating BK channel function. Here we re
Publikováno v:
British Journal of Pharmacology. 118:378-384
1. The effects of n-alcohols on GABAA and glutamate receptor systems were examined, and in vitro effectiveness was compared with in vivo effects in mice and tadpoles. We expressed GABAA, NMDA, AMPA, or kainate receptors in Xenopus oocytes and examine
Publikováno v:
The FASEB Journal. 9:1454-1462
Molecular cloning of cDNAs coding for ligand-gated ion channel subunits makes it possible to study the pharmacology of recombinant receptors with defined subunit compositions. Many laboratories have used these techniques recently to study actions of
Publikováno v:
Journal of Biological Chemistry. 269:32768-32773
Incorporation of the gamma 2 subunit into gamma-aminobutyric acid type A (GABAA) receptors is required for the expression of benzodiazepine pharmacology, but the regions of the subunit responsible for benzodiazepine actions have not been defined. Usi
Publikováno v:
Journal of Biological Chemistry. 269:19546-19552
Microtubules are present at postsynaptic densities in brain and are proposed to be involved in anchoring neurotransmitter receptor clusters at postsynaptic membranes. However, the influence of microtubules on gamma-aminobutyric acidA (GABAA) receptor
Publikováno v:
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques. 21:3-8
Eight anticonvulsant drugs – including clonazepam, diazepam and phenobarbital – were tested for their effects on GABA-stimulated chloride uptake in rat cerebral cortical microsacs (unfiltered synaptoneurosomes). “Mid” and “high” therapeut
Autor:
R. A. Harris, S. J. Mihic
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 101(1)
It is remarkable that a simple two-carbon molecule like ethyl alcohol produces the many neurological, physiological, and societal effects that result from alcohol (ethanol) use and misuse. It is the least potent of all drugs, requiring concentrations
Autor:
S J Mihic, Donald W. Bowden, Ann L. Craddock, Sallyanne C. Fossey, Josyf C. Mychaleckyj, Paul A. Dawson
Publikováno v:
Molecular genetics and metabolism. 74(1-2)
We have carried out a detailed sequence and functional analysis of a novel human facilitative glucose transporter, designated GLUT10, located in the Type 2 diabetes-linked region of human chromosome 20q12–13.1. The GLUT10 gene is located between D2
Publikováno v:
Molecular pharmacology. 57(6)
Inhalable solvents possess significant abuse liability and produce many of the neurobehavioral effects typically associated with central nervous system-depressant agents, including motor incoordination, anxiolysis, and the elicitation of signs of phy
Publikováno v:
Drug and alcohol dependence. 51(1-2)