Zobrazeno 1 - 9
of 9
pro vyhledávání: '"S. J. M. Skinner"'
Publikováno v:
Journal of Molecular Endocrinology. 15:105-115
The insulin-like growth factors (IGF-I and IGF-II), their receptors and binding proteins (IGFBPs) are endogenously expressed in a number of tissues including the lung during fetal and neonatal development. This endogenous autocrine/paracrine IGF 'sys
Publikováno v:
Journal of neural engineering. 6(6)
In neurodegenerative disease and in acute brain injury, there is often local up-regulation of neurotrophin production close to the site of the lesion. Treatment by direct injection of neurotrophins and growth factors close to these lesion sites has r
Publikováno v:
The American journal of physiology. 271(6 Pt 1)
Transforming growth factor-beta (TGF-beta) is formed in the airways and may have a role in airway remodeling in asthma. We have studied the effects of TGF-beta on bovine airway smooth muscle cells (BASMC) in vitro. Thymidine incorporation by BASMC wa
Publikováno v:
Journal of Endocrinology. 66:1-12
SUMMARY The role of pregnenolone sulphate in adrenal steroid biosynthesis and the ability of the human adrenal gland to synthesize and secrete dehydroepiandrosterone (DHA) and dehydroepiandrosterone sulphate (DHA sulphate) was investigated. The prese
Autor:
S. J. M. Skinner, R. A. F. Couch
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 14:1-9
Tritium labelled 7α-hydroxy and 7β-hydroxy dehydroepiandrosterone were synthesised by the allylic acyloxylation of [1,2-3H(n)] dehydroepiandrosterone-3β-acetate with t-butylperbenzoate. The 7α epimer was of comparable specific activity to the sub
Publikováno v:
Biochemical Journal. 106:803-810
It is shown that the 7-dehydrocholesterol reductase-catalysed conversion of 7-dehydrocholesterol into cholesterol (II), with a 105000g microsomal pellet of rat liver in the presence of [4-(3)H(2)]NADPH, results in the transfer of radioactivity to the
Autor:
M. Akhtar, S. J. M. Skinner
Publikováno v:
The Biochemical journal. 114(1)
1. The synthesis of a number of 19-substituted androgens is described. 2. A method for the partially stereospecific introduction of a tritium label at C-19 in 19-hydroxyandrost-5-ene-3beta,17beta-diol was developed. The 19-(3)H-labelled triol produce
Publikováno v:
Scopus-Elsevier
On the basis of in vivo animal studies and on experiments of nature, it has been suggested that fetal breathing movements are essential for normal lung growth in utero. To study this hypothesis in vitro, we examined the effect of mechanical stretch o
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