Zobrazeno 1 - 10
of 694
pro vyhledávání: '"S. Ishiura"'
Publikováno v:
Materials Science Forum. :1920-1924
Amorphous alloys have many superior properties such as high tensile strength,anticorrosion and easy soft-magnetism, but few amorphous alloys have been used as final productsbecause they lack plasticity at room temperature. Thus, we have developed a n
Autor:
H, Koike, Z, Kouchi, T, Kinouchi, T, Maeda, H, Sorimachi, T C, Saido, K, Maruyama, A, Okuyama, K, Suzuki, S, Ishiura
Publikováno v:
Cytotechnology. 33(1-3)
Thimet oligopeptidase (TOP) is a thiol- andmetallo-dependent peptidase and has been shown to beone of the beta-secretase candidates. TOPexpressed in COS cells cleaved amyloid precursorprotein (APP) at the beta-secretase site, and wefound a proteolyti
Publikováno v:
Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology. 24(2)
Myotonic Dystrophy (DM), the most common form of adult-onset muscular dystrophy, comprises at least 2 subtypes, DM1 and DM2. DM1 is caused by the expansion of a CTG repeat located in the 3' untranslated region of the DM protein kinase (DMPK) gene. Re
Autor:
S, Ishiura
Publikováno v:
Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. 19(5)
The neurotransmitter serotonin is known to play a key role in determining emotional state in higher animals, especially in humans. Pharmacological studies have highlighted a subset of serotonin receptor subtypes (1A, 2B and 2C) worthy of knockout ana
Autor:
N, Takahashi, S, Ishiura
Publikováno v:
Nihon rinsho. Japanese journal of clinical medicine. 57(4)
Although the expansion of an unstable CTG repeat is known to be responsible for myotonic dystrophy (DM), the mechanism by which this genetic defect induces the disease has not yet been elucidated. In patients with DM, low expression of total DM prote
Publikováno v:
Biochemical pharmacology. 56(4)
Recent studies indicate that calpain, a cytosolic Ca2+-dependent protease, constitutes a large family comprising ubiquitous, tissue-specific, and atypical calpains. p94 is a homologue of the catalytic large subunit of calpain, expressed predominantly
Autor:
H, Ueda, N, Kameda, T, Baba, N, Terada, M, Shimokawa, M, Yamamoto, S, Ishiura, T, Kobayashi, S, Ohno
Publikováno v:
The Histochemical journal. 30(4)
The subcellular localization of myotonic dystrophy protein kinase has been examined in human cardiac muscles with confocal laser-scanning microscopy and electron microscopy. A polyclonal antibody was produced against the synthesized peptide from a hu
Autor:
S, Ishiura
Publikováno v:
Nihon rinsho. Japanese journal of clinical medicine. 55(12)
The mutation underlying myotonic dystrophy is the expansion of polymorphic CTG repeat in the 3'-noncoding region of the myotonin protein kinase (MtPK) gene mapping to chromosome 19q13.3. A full-length cDNA of human MtPK was cloned and expressed in CO
Publikováno v:
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 42
Autor:
M, Shimokawa, S, Ishiura, N, Kameda, M, Yamamoto, N, Sasagawa, N, Saitoh, H, Sorimachi, H, Ueda, S, Ohno, K, Suzuki, T, Kobayashi
Publikováno v:
The American journal of pathology. 150(4)
It is quite important to know the exact localization and function of myotonin protein kinase (MtPK), identified as the gene product of myotonic dystrophy, the most prevalent disease with multisystem disorders among muscular dystrophies. To investigat