Výsledky vyhledávání

Ezetimibe improves glucose metabolism by ameliorating hepatic function in Japanese patients with type 2 diabetes

Autor: Yasuto Matsuo, Eiichi Araki, S. Isami, Taiji Sekigami, Rieko Goto, Shinji Ichimori, Kenro Nishida, Takako Maeda, Junji Kawashima, Seiya Shimoda, Shoko Kodama, Noboru Furukawa

Publikováno v: Journal of Diabetes Investigation. 3:179-184

Aims/Introduction: Several experimental studies have shown that ezetimibe improves steatosis and insulin resistance in the liver. This suggests that ezetimibe may improve glucose metabolism, as well as lipid metabolism, by inhibiting hepatic lipid ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e1749117c8c754ad7730d139eb25d476
https://doi.org/10.1111/j.2040-1124.2011.00147.x

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The effect of group-based lifestyle interventions on risk factors and insulin resistance in subjects at risk for metabolic syndrome: the Tabaruzaka Study 1

Autor: Eiichi Araki, Hiroshi Matsuo, S. Isami, Tomoaki Yoshinaga, Takeshi Yamashiro, Takeshi Matsumura, Kumiko Fukumoto, Chang Nian Wei, Hiroyuki Motoshima, Daisuke Kukidome, Takeshi Nishikawa, Atsushi Ueda

Publikováno v: Diabetes, Obesity and Metabolism. 12:790-797

Aim: The aim of this study was to evaluate the efficacy of two group-based lifestyle interventions in ameliorating the risk factors of metabolic syndrome (MS) and insulin resistance. Methods: Ninety-eight subjects who had at least one component of MS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3960d5357911448ed85056fd55300dc7
https://doi.org/10.1111/j.1463-1326.2010.01236.x

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Analysis of vasopressin receptor type II (V2R) gene in three Japanese pedigrees with congenital nephrogenic diabetes insipidus: identification of a family with complete deletion of the V2R gene

Autor: Hiroko Iwamatsu, Kohei Yamaguchi, Eiichi Araki, Motoaki Shichiri, S. Isami, Hideki Kishikawa, Nobuhiro Miyamura, Ryohei Yoshimura, Hideaki Jinnouchi

Publikováno v: European Journal of Endocrinology. 134:689-698

Jinnouchi H, Araki E, Miyamura N, Kishikawa H, Yoshimura R, Isami S, Yamaguchi K, Iwamatsu H, Shichiri M. Analysis of vasopressin receptor type II (V2R) gene in three Japanese pedigrees with congenital nephrogenic diabetes insipidus: identification o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c10251c033dbb9637db55035dacd5fc9
https://doi.org/10.1530/eje.0.1340689

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Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study

Autor: Naohiko Furuyoshi, Takao Miyata, Hideki Kishikawa, S. Motoyoshi, Yujiro Kojima, Eiichi Araki, S. Isami, Motoaki Shichiri, Yasuo Ohkubo

Publikováno v: Diabetes Research and Clinical Practice. 28:103-117

To examine whether intensive glycemic control could decrease the frequency or severity of diabetic microvascular complications, we performed a prospective study of Japanese patients with non-insulin-dependent diabetes mellitus (NIDDM) treated with mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd10f1253ab818d151a5b778f1118723
https://doi.org/10.1016/0168-8227(95)01064-k

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Expression of insulin receptor on clonal pancreatic alpha cells and its possible role for insulin-stimulated negative regulation of glucagon secretion

Autor: Eiichi Araki, S. Isami, Hideaki Jinnouchi, Nobuhiro Miyamura, Tetsuya Shirotani, S. Ura, Hideki Kishikawa, K. Kisanuki, M. Uehara, Motoaki Shichiri

Publikováno v: Diabetologia. 38:422-429

In pancreatic alpha cells, the existence and function of the insulin receptor has not yet been fully established. In this study, to confirm the expression of functional insulin receptors in pancreatic alpha cells, we performed: 1) insulin receptor bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea7e6875393b89738fb84483ae911de
https://doi.org/10.1007/bf00410279

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Effect on insulin sensitivity of angiotensin converting enzyme inhibitors with or without a sulphydryl group: Bradykinin may improve insulin resistance in dogs and humans

Autor: Motoaki Shichiri, Yasuo Ohkubo, S. Isami, Tomohiko Yano, Nobuhiro Miyamura, Takao Miyata, K. Kisanuki, Hideki Kishikawa, M. Uehara

Publikováno v: Diabetologia. 37:300-307

The present study compared the effect on insulin sensitivity of ACE inhibitors with a sulphydryl group (captopril) or those without a sulphydryl group (delapril and enalapril) during the hyperinsulinaemic euglycaemic clamp test in both animal and cli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f94a6a751557ebb857be8c2ebd05e781
https://doi.org/10.1007/bf00398058

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Molecular scanning of the insulin receptor substrate-1 (IRS-1) gene in Japanese patients with NIDDM: identification of five novel polymorphisms

Autor: Ryohei Yoshimura, Eiichi Araki, Kohji Matsuda, Nobuhiro Miyamura, Hideki Kishikawa, S. Isami, Seiya Shimoda, Motoaki Shichiri, Tetsuya Shirotani, Mikio Todaka, S. Motoyoshi, S. Ura, C R Kahn

Publikováno v: Diabetologia. 39(5)

Since the insulin receptor substrate-1 (IRS-1) is the major substrate of the insulin receptor tyrosine kinase and has been shown to activate phosphatidylinositol (PI) 3-kinase and promote GLUT4 translocation, the IRS-1 gene is a potential candidate f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a52e9f05db563af8d102f8d18bea7750
https://pubmed.ncbi.nlm.nih.gov/8739921

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Bradykinin enhances GLUT4 translocation through the increase of insulin receptor tyrosine kinase in primary adipocytes: evidence that bradykinin stimulates the insulin signalling pathway

Autor: Nobuhiro Miyamura, Kengo Kaneko, M. Uehara, Motoaki Shichiri, K. Matsumoto, Tetsuya Shirotani, Mikio Todaka, S. Ura, Hideki Kishikawa, Eiichi Araki, S. Isami, S. Motoyoshi

Publikováno v: Diabetologia. 39(4)

It has been suggested that bradykinin stimulates glucose uptake in experiments in vivo and in cultured cells. However, its mechanism has not yet been fully elucidated. In this study, the effects of bradykinin on the insulin signalling pathway were ev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9608ed5fa7bfb9a2878d9d6208ef3ec
https://pubmed.ncbi.nlm.nih.gov/8777990

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