Zobrazeno 1 - 10
of 78
pro vyhledávání: '"S. Iqball"'
Autor:
H. E. Maunder, J. Wright, B. R. Kolli, C. R. Vieira, T. T. Mkandawire, S. Tatoris, V. Kennedy, S. Iqball, G. Devarajan, S. Ellis, Y. Lad, N. G. Clarkson, K. A. Mitrophanous, D. C. Farley
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
The maximum titre of therapeutic viral vectors can be adversely affected by the encoded transgene. Here the authors repress transgene expression in producing cells by employing the tryptophan RNA-binding attenuation protein and show that it improves
Externí odkaz:
https://doaj.org/article/461f4560315c4da1a66c68b9087e432c
Akademický článek
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Autor:
N. G. Clarkson, C. R. Vieira, D. Farley, Scott Ellis, T. T. Mkandawire, Jordan Wright, S. Tatoris, B. R. Kolli, Kyri Mitrophanous, S. Iqball, G. Devarajan, Vicky Kennedy, Yatish Lad, H. E. Maunder
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
A key challenge in the field of therapeutic viral vector/vaccine manufacturing is maximizing production. For most vector platforms, the ‘benchmark' vector titres are achieved with inert reporter genes. However, expression of therapeutic transgenes
Autor:
S. Iqball, Naoyasu Umeda, Shu Kachi, Katsutoshi Yokoi, Peter A. Campochiaro, Katie Binley, Daisuke Muramatu, O. Kan, Hideo Akiyama, Stuart Naylor
Publikováno v:
Human Gene Therapy. 20:31-39
Equine infectious anemia virus (EIAV) is a nonprimate lentivirus that does not cause human disease. Subretinal injection into mice of a recombinant EIAV lentiviral vector in which lacZ is driven by a CMV promoter (EIAV CMV LacZ) resulted in rapid and
Autor:
O. Kan, S. Iqball, Robert E MacLaren, Robin R. Ali, Kamaljit S. Balaggan, S. E. Barker, Margaret Esapa, Rachael A. Pearson, James W B Bainbridge, Katie Binley, Yanai Duran, Stuart Naylor, Andrew Smith
Publikováno v:
Gene Therapy. 13:1153-1165
We evaluated the efficacy of equine infectious anaemia virus (EIAV)-based lentiviral vectors encoding endostatin (EIAV.endostatin) or angiostatin (EIAV.angiostatin) in inhibiting angiogenesis and vascular hyperpermeability in the laser-induced model
Autor:
Susan M. Kingsman, S. Iqball, Stuart Naylor, Mahesh de Alwis, Leigh Martin, Robin R. Ali, Adrian J. Thrasher, Patrick H. Maxwell, Katie Binley, Hayley Spearman, Zoe Askham
Publikováno v:
Blood. 100:2406-2413
Anemia is a common clinical problem, and there is much interest in its role in promoting left ventricular hypertrophy through increasing cardiac workload. Normally, red blood cell production is adjusted through the regulation of erythropoietin (Epo)
Publikováno v:
Gene Therapy. 6:1721-1727
Recombinant adenoviral vectors have a number of advantages for gene therapy, including transduction of a range of dividing and non-dividing cell types. However, this broad range may be a disadvantage if non-target cells are transduced and are adverse
Publikováno v:
Supplemental Proceedings: Materials Processing and Interfaces, Volume 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81eed4a8e8eb02c8e77646fc02908389
https://doi.org/10.1002/9781118356074.ch52
https://doi.org/10.1002/9781118356074.ch52
Autor:
Liang Fong-Wong, Vinay Thoree, Katie Binley, Kyriacos A. Mitrophanous, S. Iqball, Scott Ellis
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 1, Iss C (2012)
Molecular Therapy. Nucleic Acids
Molecular Therapy. Nucleic Acids
The interest in integrase-defective lentiviral vectors (IDLVs) stems from their potential advantage of large cloning capacity and broad cell tropism while avoiding the possibility of insertional mutagenesis. Here, we directly compared the transducing
Autor:
Gabrielle H. Kingsley, A. C. S. Keat, R. A. Hughes, I. L. Maclean, P. Woo, Stella C. Knight, S. Iqball
Publikováno v:
Clinical and Experimental Immunology. 91:214-219
SUMMARYThe spondartliropathy (Sp)-associated HLA-B27 antigen includes al least seven subtypes. B*2701–07, of which 01, 02, 05 and 07 occur in Caucasians. This study examined the B27 subtype distribution in British patients with Sp. The 133 HLA-B27+