Zobrazeno 1 - 10
of 17
pro vyhledávání: '"S. Innaimo"'
Autor:
Eugene V. Genovesi, S. Innaimo, Lucinda Lamb, D. Taylor, Ivette Medina, Richard J. Colonno, M. Seifer, Junius M. Clark
Publikováno v:
Antiviral Research. 48:197-203
Lobucavir (BMS-180194), a cyclobutyl-guanosine nucleoside analogue, effectively reduced WHV-viremia in chronically infected carrier woodchucks (Marmota monax) by daily per os treatment. WHV-viremia in the animals was measured by the serum content of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272d72d898103a0f51c9df7a3fa9cf34
https://doi.org/10.1016/s0166-3542(00)00128-5
https://doi.org/10.1016/s0166-3542(00)00128-5
Autor:
Ivette Medina, Junius M. Clark, D. Taylor, S. Innaimo, David N. Standring, Richard J. Colonno, M. Seifer, Lucinda Lamb, Eugene V. Genovesi
Publikováno v:
Antimicrobial Agents and Chemotherapy. 42:3209-3217
Human hepatitis B virus (HBV), the prototype member of a small family of hepadnaviruses, is an enveloped DNA virus with a partially double-stranded 3.2-kb circular genome. HBV infection is widespread and is a major cause of human liver disease (4). W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::999e532f984d5705f5f12213f1cb75c3
https://doi.org/10.1128/aac.42.12.3209
https://doi.org/10.1128/aac.42.12.3209
Autor:
G. A. Jacobs, S. Innaimo, William A. Slusarchyk, O. Kocy, J.E. Sundeen, Robert Zahler, Alain Martel, M. G. Young, Sam T. Chao, Jean-Paul Daris, Gregory S. Bisacchi, Richard J. Colonno, C. Bachard, Philippe Lapointe, Z. Merchant
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:127-132
BMS-200475, a novel carbocyclic analog of 2′-deoxyguanosine, is a potent inhibitor of hepatitis B virus in vitro (ED50 = 3 nM) with relatively low cytotoxicity (CC50 = 21–120 μM). A practical 10-step asymmetric synthesis was developed affording
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f254f1ed35e99aef5acd2c244ca770e
https://doi.org/10.1016/s0960-894x(96)00594-x
https://doi.org/10.1016/s0960-894x(96)00594-x
Publikováno v:
Journal of Clinical and Translational Hepatology
Since the first approval of interferon for the treatment of chronic hepatitis B virus (HBV) infection in 1992, six additional antivirals have been developed: pegylated interferon-alfa2a, and the oral antivirals lamivudine, adefovir, telbivudine, ente
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d31b84e4d940c1db900c945cc283788
https://doi.org/10.14218/jcth.2013.00006
https://doi.org/10.14218/jcth.2013.00006
Autor:
Robert Zahler, Alain Martel, Richard J. Colonno, G. S. Bisacchi, O. Kocy, S. Innaimo, M. G. Young, Jean-Paul Daris, G. A. Jacobs, Sam T. Chao, Z. Merchant, William A. Slusarchyk, Joseph E. Sundeen, Philippe Lapointe, C. Bachard
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5196cba329e4c401131ecdd8edf1eb7f
https://doi.org/10.1002/chin.199720199
https://doi.org/10.1002/chin.199720199
Autor:
Peter Egli, Robert Zahler, S. Innaimo, J. Kent Rinehart, Todd Wilson, Gregory S. Bisacchi, Richard J. Colonno, Gregory Yamanaka
BMS-200475 was recently shown to have potent antiviral activity against hepatitis B virus (50% effective concentration = 3.7 nM; 50% cytotoxic concentration = 30 μM). In metabolic studies in both HepG2 and hepatitis B virus-transfected 2.2.15 human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c689f49425828f8f9bab32d9c9e16aa
https://europepmc.org/articles/PMC89048/
https://europepmc.org/articles/PMC89048/
Autor:
Richard J. Colonno, Robert Zahler, M. Seifer, David N. Standring, S. Innaimo, Gregory S. Bisacchi
Publikováno v:
Antimicrobial agents and chemotherapy. 41(7)
BMS-200475 is a novel carbocyclic 2'-deoxyguanosine analog found to possess potent and selective anti-hepatitis B virus (anti-HBV) activity. BMS-200475 is distinguished from guanosine by replacement of the natural furanose oxygen on the sugar moiety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc7f3e8070695975ec8b3b7d778a2f65
https://pubmed.ncbi.nlm.nih.gov/9210663
https://pubmed.ncbi.nlm.nih.gov/9210663
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