Zobrazeno 1 - 10 of 11 pro vyhledávání: '"S. I. Foundling"'
1
Effect of Point Mutations on the Kinetics and the Inhibition of Human Immunodeficiency Virus Type 1 Protease: Relationship to Drug Resistance
Autor: Yingzhang Lin, Ben M. Dunn, Raterman D, S. I. Foundling, Suvit Thaisrivongs, Lin Hong, Leelamanit W, Shah M, Lin X, Robert L. Heinrikson
Publikováno v: Biochemistry. 34:1143-1152
Mutations of human immunodeficiency virus type 1 (HIV-1) protease at four positions, Val82, Asp30, Gly48, and Lys45 were analyzed for the resulting effects on kinetics and inhibition. In these mutants, Val82 was substituted separately by Asn, Glu, Al
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4a7e7e6f487a630d588cc27279820cc
https://doi.org/10.1021/bi00004a007
Zobrazit plný text záznamu
2
Structural studies of the retroviral proteinase from avian myeloblastosis associated virus
Autor: Juraj Sedlacek, J. J. Wendoloski, S. I. Foundling, Douglas H. Ohlendorf, Petr Štrop, F. R. Salemme
Publikováno v: Proteins: Structure, Function, and Genetics. 14:382-391
The structure of the retroviral proteinase from avian myeloblastosisassociated virus (MAV) has been determined and refined at 2.2 A resolution. This structure is compared with those of homologous proteinases from Rous sarcoma virus (RSV) and human im
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaaa62dba04258d1a8cd24057dec8d59
https://doi.org/10.1002/prot.340140307
Zobrazit plný text záznamu
4
Structure of secreted aspartic proteinases from Candida. Implications for the design of antifungal agents
Autor: C, Abad-Zapatero, R, Goldman, S W, Muchmore, C, Hutchins, T, Oie, K, Stewart, S M, Cutfield, J F, Cutfield, S I, Foundling, T L, Ray
Publikováno v: Advances in experimental medicine and biology. 436
Pathogens of the genus Candida can cause life threatening infections in immuno-compromised patients. The three-dimensional structures of two closely related secreted aspartic proteinases from C. albicans complexed with a potent (Ki = 0.17 nM) inhibit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6d00f25b6b13ee08019e790a8cc919a1
https://pubmed.ncbi.nlm.nih.gov/9561233
Zobrazit plný text záznamu
6
Human breast milk contains procathepsin D--detection by specific antibodies
Autor: V, Vĕtvicka, J, Vágner, M, Baudys, J, Tang, S I, Foundling, M, Fusek
Publikováno v: Biochemistry and molecular biology international. 30(5)
The presence of the zymogen of cathepsin D in human milk was detected using antibodies specific for the proenzyme and by the proteolytic activity at low pH. The antibodies were raised against a synthetic propeptide of human cathepsin D and were teste
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f7cba686ed04ea9b6c835c47d8633a79
https://pubmed.ncbi.nlm.nih.gov/8220241
Zobrazit plný text záznamu
7
Crystal structure of a complex of HIV-1 protease with a dihydroxyethylene-containing inhibitor: comparisons with molecular modeling
Autor: N. Thanki, J. K. Rao, J. O. Hui, Joseph B. Moon, Robert L. Heinrikson, A G Tomasselli, Alexander Wlodawer, W. J. Howe, Suvit Thaisrivongs, S. I. Foundling
Publikováno v: Protein science : a publication of the Protein Society. 1(8)
The structure of a crystal complex of recombinant human immunodeficiency virus type 1 (HIV-1) protease with a peptide-mimetic inhibitor containing a dihydroxyethylene isostere insert replacing the scissile bond has been determined. The inhibitor is N
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12f8ac2b90da63155fe2bc0e30d64f0f
https://pubmed.ncbi.nlm.nih.gov/1304383
Zobrazit plný text záznamu
10
Crystallographic studies of reduced bond inhibitors complexed with an aspartic proteinase
Autor: S. I. Foundling, J. Cooper, F. E. Watson, L. H. Pearl, A. Hemmings, S. P. Wood, T. Blundell, A. Hallett, D. M. Jones, J. Sueiras, B. Atrash, M. Szelke
Publikováno v: Journal of cardiovascular pharmacology. 10
To aid in the design of an effective inhibitor to human renin, it is essential to have a detailed knowledge of how this aspartic proteinase interacts with its substrate, angiotensinogen. Human renin shows a stringent specificity toward the Leu-Val bo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c566ca055c88ba5344d7a00480c03567
https://pubmed.ncbi.nlm.nih.gov/2485065
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje