Zobrazeno 1 - 10
of 59
pro vyhledávání: '"S. Houlbrook"'
DNA polymerase beta (Pol beta) is important for the base excision repair (BER) pathway. Overexpression of Pol beta is frequently found in cancer cells and is thought to be associated with tumorigenesis. In this study, we examined BER fidelity in extr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2107294eee0e88be8d9dddef10b0bae
https://doi.org/10.1093/mutage/gel070
https://doi.org/10.1093/mutage/gel070
Autor:
Kenneth J. O'Byrne, S. Houlbrook, M Taylor, David Propper, S. Varcoe, M I Koukourakis, Denis C. Talbot, A L Harris, S D Love, Trivadi S. Ganesan, J P Braybrooke, Adam V. Patterson
Publikováno v:
British Journal of Cancer
Thymidine phosphorylase (TP) is an essential enzyme for the biochemical activation of 5-fluorouracil (5-FU). Interferon upregulates TP in vivo, although the dose and schedule of interferon for optimal biomodulation of 5-FU is not known. In this study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c1744a3bce7bd4f0586d843d312b735
https://doi.org/10.1054/bjoc.2000.1230
https://doi.org/10.1054/bjoc.2000.1230
Autor:
Jonathan R. A. Roffey, Christopher J. Moody, Ian J. Stratford, Elizabeth Swann, S. Houlbrook, S D Lockyer
Publikováno v:
Anti-Cancer Drugs. 10:577-590
A number of thiazolyl indolequinones have been prepared and evaluated for their antitumor properties. The compounds were synthesized from the appropriate indole, building up the thiazole ring using the Hantzsch reaction. Cytotoxic activity was determ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e7c0e0e97609f33f9ddb536c81c42ee
https://doi.org/10.1097/00001813-199907000-00010
https://doi.org/10.1097/00001813-199907000-00010
Autor:
Helen Turley, M. Comley, S Houlbrook, Akihiko Kikuchi, N. Nozaki, Al Harris, Ian D. Hickson, K C Gatter
Publikováno v:
Scopus-Elsevier
British Journal of Cancer
British Journal of Cancer
In mammalian cells, there are two isoforms of DNA topoisomerase II, designated alpha (170-kDa form) and beta (180-kDa form). Previous studies using cell lines have shown that the topoisomerase IIalpha and beta isoforms are differentially regulated du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b76b641d0512d6f76ecb0ac7421a243
https://doi.org/10.1038/bjc.1997.227
https://doi.org/10.1038/bjc.1997.227
Publikováno v:
Journal of Medicinal Chemistry. 38:1039-1043
A number of analogues of the naturally occurring thiazolylindolequinone BE 10988, a reported potent inhibitor of topoisomerase II, have been prepared and evaluated. The compounds were synthesized from 4-(benzyloxy)-5-methoxy-1-methylindole by appropr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6295d07e122f0df4242152df94c39c3a
https://doi.org/10.1021/jm00006a024
https://doi.org/10.1021/jm00006a024
Autor:
Ian J. Stratford, J. Carmichael, Al Harris, CM Addison, S Houlbrook, Ian D. Hickson, S. L. Davies
Publikováno v:
British Journal of Cancer
Scopus-Elsevier
Scopus-Elsevier
Topoisomerase II is a key target for many anti-cancer drugs used to treat breast cancer. In human cells there are two closely related, but differentially expressed, topoisomerase II isoforms, designated topoisomerase II alpha and beta. Here, we repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e147387a925673a5dfb1d0d5a9322162
http://europepmc.org/articles/PMC2034103
http://europepmc.org/articles/PMC2034103
Autor:
J. Carmichael, N Robertson, Adam V. Patterson, Ian J. Stratford, S. Houlbrook, Gerald E. Adams, Adrian L. Harris, Stephens Ma
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 29:369-372
Purpose: To determine the dependency of the aerobic and hypoxic toxicity of tirapazamine on the intracellular activity of DT-diaphorase. Methods and Materials: A panel of 18 human cell lines comprising predominantly small cell and nonsmall cell lung
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c8270d95209e4ba5ffa218ce7613e0e
https://doi.org/10.1016/0360-3016(94)90291-7
https://doi.org/10.1016/0360-3016(94)90291-7
Publikováno v:
European Journal of Cancer. 29:1152-1157
In this study we describe the effects of tamoxifen, toremifene and their 4-hydroxy and N -desmethyl metabolites on the toxicity of a range of drugs to human breast and lung cancer and to Chinese hamster ovary cell lines, determined using a tetrazoliu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95c6e477ef344b868c03706a35c91237
https://doi.org/10.1016/s0959-8049(05)80306-5
https://doi.org/10.1016/s0959-8049(05)80306-5
Autor:
N. S. A. Stuart, S. Houlbrook, J. Carmichael, J. Kirk, K. Tonkin, Ernst A. Lien, Philip A. Philip, Adrian L. Harris
Publikováno v:
British Journal of Cancer
Scopus-Elsevier
Scopus-Elsevier
Twenty-six patients with relapsed or drug-resistant cancer were treated with a combination of oral etoposide (300 mg day-1 for 3 days) and high-dose oral tamoxifen as a potential modulator of drug resistance (480 or 720 mg day-1 for 6 days beginning
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9962538ab0c44553a21568c52d77c63
http://europepmc.org/articles/PMC1977984
http://europepmc.org/articles/PMC1977984
Autor:
Helen Rockett, Markku Anttila, Trivadi S. Ganesan, J P Braybrooke, A L Harris, Denis C. Talbot, Katherine A. Vallis, Juha Ellmen, S. Houlbrook
Publikováno v:
Scopus-Elsevier
PURPOSE: Expression of P-glycoprotein (Pgp), which confers the multidrug resistance (MDR) phenotype, is thought to contribute to the insensitivity of renal cell cancer (RCC) to chemotherapy. The development of Pgp inhibitors for clinical application
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37635d4f7a28b3dbf545bbf89f88b9ed
http://ora.ox.ac.uk/objects/uuid:d1e81b9f-4e01-4a47-b9a4-61e2020f502f
http://ora.ox.ac.uk/objects/uuid:d1e81b9f-4e01-4a47-b9a4-61e2020f502f