Výsledky vyhledávání - "S. Hossein Fatemi"

Metabotropic glutamate receptor 5 tracer [18F]-FPEB displays increased binding potential in postcentral gyrus and cerebellum of male individuals with autism: a pilot PET study

Autor: George M. Realmuto, Suma Jacob, Timothy D. Folsom, José V. Pardo, Susanne S. Lee, James Robert Brašić, S. Hossein Fatemi, Hiroto Kuwabara, Dean F. Wong, Anil Mathur

Publikováno v: Cerebellum & Ataxias, Vol 5, Iss 1, Pp 1-8 (2018)

Background Autism is a neurodevelopmental disorder that is first manifested during early childhood. Postmortem experiments have identified significantly elevated expression of metabotropic glutamate receptor 5 (mGluR5) in cerebellar vermis and prefro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb5cd55467dd9a7372d92717cffb2350
http://link.springer.com/article/10.1186/s40673-018-0082-1

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The effects of prenatal H1N1 infection at E16 on FMRP, glutamate, GABA, and reelin signaling systems in developing murine cerebellum

Autor: Timothy D. Folsom, S. Hossein Fatemi, Stephanie B. Liesch, Paul Thuras, Rachel E. Kneeland, Mahtab K Yousefi

Publikováno v: Journal of Neuroscience Research. 95:1110-1122

Prenatal viral infection has been identified as a potential risk factor for the development of neurodevelopmental disorders such as schizophrenia and autism. Additionally, dysfunction in gamma-aminobutyric acid, Reelin, and fragile X mental retardati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0db3cdf0c2f0a0e109ecebcd4ecb5584
https://doi.org/10.1002/jnr.23949

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Quantitative proteomics of forebrain subcellular fractions in fragile X mental retardation 1 knockout mice following acute treatment with 2‐Methyl‐6‐(phenylethynyl)pyridine: Relevance to developmental study of schizophrenia

Autor: S. Hossein Fatemi, LeeAnn Higgins, Todd W. Markowski, Timothy D. Folsom, Timothy J. Griffin

Publikováno v: Synapse. 73

The fragile X mental retardation 1 knockout (Fmr1 KO) mouse replicates behavioral deficits associated with autism, fragile X syndrome, and schizophrenia. Less is known whether protein expression changes are consistent with findings in subjects with s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30e731a0ef8d03bfdbbd482628dd1888
https://doi.org/10.1002/syn.22069

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Protein expression of targets of the FMRP regulon is altered in brains of subjects with schizophrenia and mood disorders

Autor: Paul Thuras, S. Hossein Fatemi, Timothy D. Folsom

Publikováno v: Schizophrenia Research. 165:201-211

Fragile X mental retardation protein (FMRP) is an RNA binding protein with 842 target mRNAs in mammalian brain. Silencing of the fragile X mental retardation 1 (FMR1) gene leads to loss of expression of FMRP and upregulated metabotropic glutamate rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e33b3a1dc3211fa658fe5c69e2b9c73
https://doi.org/10.1016/j.schres.2015.04.012

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Metabotropic glutamate receptor 5 tracer [

Autor: S Hossein, Fatemi, Dean F, Wong, James R, Brašić, Hiroto, Kuwabara, Anil, Mathur, Timothy D, Folsom, Suma, Jacob, George M, Realmuto, José V, Pardo, Susanne, Lee

Publikováno v: Cerebellum & Ataxias

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7d2278f4e389973d8674b35dc111b098
https://pubmed.ncbi.nlm.nih.gov/29449954

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Altered subcellular localization of fragile X mental retardation signaling partners and targets in superior frontal cortex of individuals with schizophrenia

Autor: Timothy D. Folsom, Paul Thuras, S. Hossein Fatemi

Publikováno v: Neuroreport. 28(16)

Schizophrenia is a severe, debilitating, neurodevelopmental disorder that affects 1% of the world's population. Recent findings from our laboratory have identified reduced levels of fragile X mental retardation protein (FMRP) and several downstream F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ede57fbbcf9e0c64e5389529cc2aae9
https://pubmed.ncbi.nlm.nih.gov/28902714

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GABAergic dysfunction in schizophrenia and mood disorders as reflected by decreased levels of glutamic acid decarboxylase 65 and 67 kDa and Reelin proteins in cerebellum

Autor: S Hossein, Fatemi, S, Hossein Fatemi, Joel M, Stary, Julie A, Earle, Mohsen, Araghi-Niknam, Elisabeth, Eagan

Publikováno v: Schizophrenia Research. 72:109-122

Glutamic acid decarboxylase (GAD) is the rate limiting enzyme responsible for conversion of glutamate to gamma-aminobutyric acid (GABA) regulating levels of glutamate and GABA in the mammalian brain. Reelin is an extracellular matrix protein that hel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30a7d7128883225b12245e69061d3853
https://doi.org/10.1016/j.schres.2004.02.017

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Viral infection, inflammation and schizophrenia

Autor: S. Hossein Fatemi, Rachel E. Kneeland

Publikováno v: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 42:35-48

Schizophrenia is a severe neurodevelopmental disorder with genetic and environmental etiologies. Prenatal viral/bacterial infections and inflammation play major roles in the genesis of schizophrenia. In this review, we describe a viral model of schiz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2197955565a1b01574d0cadba61edf6b
https://doi.org/10.1016/j.pnpbp.2012.02.001

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