Zobrazeno 1 - 10
of 435
pro vyhledávání: '"S. Hitchcock"'
Autor:
Andrew P. Stone, Emma Rand, Gabriel Thornes, Alasdair G. Kay, Amanda L. Barnes, Ian S. Hitchcock, Paul G. Genever
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Background Bone marrow stromal cells (BMSCs) are highly heterogeneous, which may reflect their diverse biological functions, including tissue maintenance, haematopoietic support and immune control. The current understanding of the mechanisms
Externí odkaz:
https://doaj.org/article/a89c2df4abe04a91b84f62804856201c
Publikováno v:
Platelets, Vol 32, Iss 6, Pp 770-778 (2021)
Thrombopoietin (TPO) and its receptor, MPL, are the primary regulators of platelet production and critical for hematopoietic stem cell (HSC) maintenance. Since TPO was first cloned in 1994, the physiological and pathological roles of TPO and MPL have
Externí odkaz:
https://doaj.org/article/8a3d80fe6cdf48ee8e383d79b524fbb5
Publikováno v:
Wellcome Open Research, Vol 6 (2021)
Background: Polyparasitism is commonplace in countries where endemicity for multiple parasites exists, and studies in animal models of coinfection have made significant inroads into understanding the impact of often competing demands on the immune sy
Externí odkaz:
https://doaj.org/article/d38458751b9e4eaba44bc51751e561da
Autor:
Min-Sik Lee, Courtney Dennis, Insia Naqvi, Lucas Dailey, Alireza Lorzadeh, George Ye, Tamara Zaytouni, Ashley Adler, Daniel S. Hitchcock, Lin Lin, Megan T. Hoffman, Aladdin M. Bhuiyan, Jaimie L. Barth, Miranda E. Machacek, Mari Mino-Kenudson, Stephanie K. Dougan, Unmesh Jadhav, Clary B. Clish, Nada Y. Kalaany
Publikováno v:
Nature. 616:339-347
Autor:
Tess A. Stanly, Rakesh Suman, Gulab Fatima Rani, Peter J. O’Toole, Paul M. Kaye, Ian S. Hitchcock
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Platelets are specialized anucleate cells that play a major role in hemostasis following vessel injury. More recently, platelets have also been implicated in innate immunity and inflammation by directly interacting with immune cells and releasing pro
Externí odkaz:
https://doaj.org/article/31955ef5a9c6409ebffc1345a00b0a13
Autor:
Tamara Zaytouni, Pei-Yun Tsai, Daniel S. Hitchcock, Cory D. DuBois, Elizaveta Freinkman, Lin Lin, Vicente Morales-Oyarvide, Patrick J. Lenehan, Brian M. Wolpin, Mari Mino-Kenudson, Eduardo M. Torres, Nicholas Stylopoulos, Clary B. Clish, Nada Y. Kalaany
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Obesity is an established risk factor for pancreatic ductal adenocarcinoma (PDA). Here the authors show that obesity induces the expression of the mitochondrial form of arginase ARG2 in PDA and that ARG2 silencing or loss results in ammonia accumulat
Externí odkaz:
https://doaj.org/article/2bac1b53384648ab8ef09add810f760d
Autor:
Taru Muranen, Marcin P. Iwanicki, Natasha L. Curry, Julie Hwang, Cory D. DuBois, Jonathan L. Coloff, Daniel S. Hitchcock, Clary B. Clish, Joan S. Brugge, Nada Y. Kalaany
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Inhibition of PI3K/mTOR, which mimics nutrient starvation, causes death of detached but not matrix-attached cancer cells. Here the authors show that nutrient restriction of epithelial cells causes uptake of the matrix protein laminin, which results i
Externí odkaz:
https://doaj.org/article/556105391f034b16b025473af6af6511
Autor:
Olivier Preham, Flaviane A. Pinho, Ana Isabel Pinto, Gulab Fatima Rani, Najmeeyah Brown, Ian S. Hitchcock, Hiro Goto, Paul M. Kaye
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Human visceral leishmaniasis, a parasitic disease of major public health importance in developing countries, is characterized by variable degrees of severity of anemia, but the mechanisms underlying this change in peripheral blood have not been thoro
Externí odkaz:
https://doaj.org/article/b02b3e571f0c4ab0b44fbdf15a01e58c