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Akademický článek

Protein Kinase A Regulates Platelet Phosphodiesterase 3A through an A-Kinase Anchoring Protein Dependent Manner

Autor: Jawad S. Khalil, Robert Law, Zaher Raslan, Lih T. Cheah, Matthew S. Hindle, Ahmed A. Aburima, Mark T. Kearney, Khalid M. Naseem

Publikováno v: Cells, Vol 13, Iss 13, p 1104 (2024)

Platelet activation is critical for haemostasis, but if unregulated can lead to pathological thrombosis. Endogenous platelet inhibitory mechanisms are mediated by prostacyclin (PGI2)-stimulated cAMP signalling, which is regulated by phosphodiesterase

Externí odkaz: https://doaj.org/article/5fd59ece11a54f34802ee4458193261a

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Akademický článek

Fibrinogen αC-subregions critically contribute blood clot fibre growth, mechanical stability, and resistance to fibrinolysis

Autor: Helen R McPherson, Cedric Duval, Stephen R Baker, Matthew S Hindle, Lih T Cheah, Nathan L Asquith, Marco M Domingues, Victoria C Ridger, Simon DA Connell, Khalid M Naseem, Helen Philippou, Ramzi A Ajjan, Robert AS Ariëns

Publikováno v: eLife, Vol 10 (2021)

Fibrinogen is essential for blood coagulation. The C-terminus of the fibrinogen α-chain (αC-region) is composed of an αC-domain and αC-connector. Two recombinant fibrinogen variants (α390 and α220) were produced to investigate the role of subre

Externí odkaz: https://doaj.org/article/c1db5394e1864b85a4927dd251608dff

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Akademický článek

Dyslipidemia-associated atherogenic oxidized lipids induce platelet hyperactivity through phospholipase Cγ2-dependent reactive oxygen species generation

Autor: Martin Berger, Katie Wraith, Casey Woodward, Ahmed Aburima, Zaher Raslan, Matthew S. Hindle, Julia Moellmann, Maria Febbraio, Khalid M. Naseem

Publikováno v: Platelets, Vol 30, Iss 4, Pp 467-472 (2019)

Oxidized low-density lipoprotein (oxLDL) and associated oxidized phosphocholine-headgroup phospholipids (oxPCs) activate blood platelets through ligation of the scavenger receptor CD36. Previously, we found that oxLDL stimulated phosphorylation of ph

Externí odkaz: https://doaj.org/article/9f0e35edf90e43f69af128f4ee3f3a2c

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Akademický článek

Atherogenic lipid stress induces platelet hyperactivity through CD36-mediated hyposensitivity to prostacyclin: the role of phosphodiesterase 3A

Autor: Martin Berger, Zaher Raslan, Ahmed Aburima, Simbarashe Magwenzi, Katie S. Wraith, Benjamin E.J. Spurgeon, Matthew S. Hindle, Robert Law, Maria Febbraio, Khalid M. Naseem

Publikováno v: Haematologica, Vol 105, Iss 3 (2020)

Prostacyclin (PGI2) controls platelet activation and thrombosis through a cyclic adenosine monophosphate (cAMP) signaling cascade. However, in patients with cardiovascular diseases this protective mechanism fails for reasons that are unclear. Using b

Externí odkaz: https://doaj.org/article/0727a8ad821745a597e71829c681e558

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Multidimensional flow cytometry reveals novel platelet subpopulations in response to prostacyclin

Autor: Lih T. Cheah, Beth A. Webb, Khalid M. Naseem, Benjamin E. J. Spurgeon, Matthew S. Hindle

Publikováno v: Journal of Thrombosis and Haemostasis. 19:1800-1812

BACKGROUND Robust platelet activation leads to the generation of subpopulations characterized by differential expression of phosphatidylserine (PS). Prostacyclin (PGI2 ) modulates many aspects of platelet function, but its influence on platelet subpo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5f2004e063a5ac3bfe16c8bc4da6e28
https://doi.org/10.1111/jth.15330

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