Zobrazeno 1 - 10 of 70 pro vyhledávání: '"S. Helfand"'
1
The role of GABAA receptors in the acute and chronic effects of ethanol: a decade of progress
Autor: Rebecca S. Helfand, Sandeep Kumar, Douglas B. Matthews, David F. Werner, Patrizia Porcu, A. Leslie Morrow, Jaime L. Diaz-Granados
Publikováno v: Psychopharmacology. 205:529-564
The past decade has brought many advances in our understanding of GABA(A) receptor-mediated ethanol action in the central nervous system. We now know that specific GABA(A) receptor subtypes are sensitive to ethanol at doses attained during social dri
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::404e0fa86c294c5845a3d6484dd634e4
https://doi.org/10.1007/s00213-009-1562-z
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2
Ab Initio Raman Spectra of β-Lactamase Inhibitor Intermediates Bound to E166A SHV β-Lactamase
Autor: Marion S. Helfand, Andrea Miani, Simone Raugei
Publikováno v: Journal of chemical theory and computation. 5(8)
The assignment and the analysis of the experimental vibrational Raman spectra of enzyme bound β-lactamase inhibitors may be of help to understand the mechanisms responsible for bacterial drug resistance. We present a computational study of the struc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fb6f467a19a4917a256e0997726f740
https://pubmed.ncbi.nlm.nih.gov/26613155
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3
Effect of the Inhibitor-Resistant M69V Substitution on the Structures and Populations of trans-Enamine β-Lactamase Intermediates
Autor: Pius S. Padayatti, Paul R. Carey, Marion S. Helfand, Marianne P. Carey, Focco van den Akker, Monica A. Totir, Robert A. Bonomo
Publikováno v: Biochemistry. 45:11895-11904
The objective of this study was to determine the molecular factors that lead to beta-lactamase inhibitor resistance for the M69V variant in SHV-1 beta-lactamase. With mechanism-based inhibitors, the beta-lactamase forms an acyl-enzyme intermediate th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a288563fb0c5aa55827716dfc047e4ae
https://doi.org/10.1021/bi060990m
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5
Clavulanic Acid Inactivation of SHV-1 and the Inhibitor-resistant S130G SHV-1 β-Lactamase
Autor: Doritza Pagan-Rodriguez, Robert A. Bonomo, Marion S. Helfand, John D. Buynak, Christopher R. Bethel, Deley L. Sulton, Yiding Liu, Xiang Zhou, Andrea M. Hujer, Jodi M. Thomson, Lily M. Ng, Vernon E. Anderson
Publikováno v: Journal of Biological Chemistry. 280:35528-35536
Clavulanic acid is a potent mechanism-based inhibitor of TEM-1 and SHV-1beta-lactamases, enzymes that confer resistance to beta-lactams in many gram-negative pathogens. This compound has enjoyed widespread clinical use as part of beta-lactam beta-lac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f7a262b07e06418c1fdc4b729c1b816d
https://doi.org/10.1074/jbc.m501251200
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6
Mechanisms by Which Anaerobic Microbiota Inhibit the Establishment in Mice of Intestinal Colonization by Vancomycin‐ResistantEnterococcus
Autor: Marion S. Helfand, Nicole J. Pultz, Curtis J. Donskey, Suja Subramanyan, Usha Stiefel
Publikováno v: The Journal of Infectious Diseases. 191:949-956
We used a mouse model to test the hypothesis that anaerobic microbiota in the colon inhibit the establishment of vancomycin-resistant enterococci (VRE) colonization by depleting nutrients within cecal contents and limiting the association of VRE with
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::483e56309bc86fe3ae7870f4a6270973
https://doi.org/10.1086/428090
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7
In Vitro Antienterococcal Activity Explains Associations between Exposures to Antimicrobial Agents and Risk of Colonization by Multiresistant Enterococci
Autor: Rebecca Hutton-Thomas, Louis B. Rice, Marion S. Helfand, Viera LakticĎvaá
Publikováno v: The Journal of Infectious Diseases. 190:2162-2166
We compared ceftriaxone and piperacillin-tazobactam at doses ranging from 0.1 to 2 times the human equivalent daily dose (HEDD), to determine their impact on gastrointestinal colonization by ampicillin- and vancomycin-resistant Enterococcus faecium C
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64d964ff212f0ccb9fec689f760793aa
https://doi.org/10.1086/425580
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8
Efficacy of Oral Ramoplanin for Inhibition of Intestinal Colonization by Vancomycin-Resistant Enterococci in Mice
Autor: Marion S. Helfand, Curtis J. Donskey, Nicole J. Pultz, Usha Stiefel
Publikováno v: Antimicrobial Agents and Chemotherapy. 48:2144-2148
Ramoplanin is a glycolipodepsipeptide antibiotic with activity against gram-positive bacteria that is in clinical trials for prevention of vancomycin-resistant Enterococcus (VRE) bloodstream infections and treatment of Clostridium difficile diarrhea.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcf094d1451b00a7cd38d206f3a33376
https://doi.org/10.1128/aac.48.6.2144-2148.2004
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9
Tazobactam Inactivation of SHV-1 and the Inhibitor-resistant Ser130 → Gly SHV-1 β-Lactamase
Autor: Xiang Zhou, Doritza Pagan-Rodriguez, Vernon E. Anderson, Marion S. Helfand, Zhaoyan Jin, Lily M. Ng, Reiko Simmons, Baochuan Guo, Robert A. Bonomo, Andrea M. Hujer, Christopher R. Bethel
Publikováno v: Journal of Biological Chemistry. 279:19494-19501
Clavulanic acid is a potent mechanism-based inhibitor of TEM-1 and SHV-1β-lactamases,enzymesthatconferresistancetoβ-lactamsinmany Gram-negative pathogens. This compound has enjoyed widespread clinical use as part of β-lactam β-lactamase inhibitor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e02ce2caf51b70f318bc1ddd208a036a
https://doi.org/10.1074/jbc.m311669200
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